Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Karl A. Hassan"'
Autor:
Claire Maher, Karl A. Hassan
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTGram-negative bacteria are intrinsically resistant to many antibiotics, due in large part to the permeability barrier formed by their cell envelope. The complex and synergistic interplay of the two Gram-negative membranes and active efflux pr
Externí odkaz:
https://doaj.org/article/401edb9210c243738063ce7de072420e
Autor:
Lucie Semenec, Amy K. Cain, Catherine J. Dawson, Qi Liu, Hue Dinh, Hannah Lott, Anahit Penesyan, Ram Maharjan, Francesca L. Short, Karl A. Hassan, Ian T. Paulsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Here, the authors characterise Acinetobacter baumanii and Klebsiella pneumoniae isolated from a single human lung infection and proceed to define their interactions to shed light on how this impacts their evolution, growth parameters, metabolism and
Externí odkaz:
https://doaj.org/article/5f95bbd00c7043c2a1a8d6977d8529eb
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Gram-negative bacteria are problematic for antibiotic development due to the low permeability of their cell envelopes. To rationally design new antibiotics capable of breaching this barrier, more information is required about the specific co
Externí odkaz:
https://doaj.org/article/d2f0d86292bc4ec58be66ebf767e3a63
Autor:
Francesca L. Short, Qi Liu, Bhumika Shah, Heather E. Clift, Varsha Naidu, Liping Li, Farzana T. Prity, Bridget C. Mabbutt, Karl A. Hassan, Ian T. Paulsen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Francesca Short et al. identify natural polyamines as substrates for a drug efflux pump in the clinically-relevant pathogen, Acinetobacter baumannii. Their results suggest that efflux pumps now known to be involved in drug resistance may have origina
Externí odkaz:
https://doaj.org/article/8e858361117f461b89e8f68cd27b2273
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT The bacterial pathogen Acinetobacter baumannii has emerged as an urgent threat to health care systems. The prevalence of multidrug resistance in this critical human pathogen is closely associated with difficulties in its eradication from the
Externí odkaz:
https://doaj.org/article/40eeff72347340c288969d049e88eb70
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/c35f24e068324f5d9c4cecac0c16bc12
Autor:
Maoge Zang, Hugo MacDermott-Opeskin, Felise G. Adams, Varsha Naidu, Jack K. Waters, Ashley B. Carey, Alex Ashenden, Kimberley T. McLean, Erin B. Brazel, Jhih-Hang Jiang, Alessandra Panizza, Claudia Trappetti, James C. Paton, Anton Y. Peleg, Ingo Köper, Ian T. Paulsen, Karl A. Hassan, Megan L. O’Mara, Bart A. Eijkelkamp
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Antimicrobial resistance is an emerging global health crisis. Consequently, we have a critical need to prolong our current arsenal of antibiotics, in addition to the development of novel treatment options.
Externí odkaz:
https://doaj.org/article/6d0881cf57d441f7bee271a358bfc5d7
Autor:
Olga V. Mavrodi, Janiece R. McWilliams, Jacob O. Peter, Anna Berim, Karl A. Hassan, Liam D. H. Elbourne, Melissa K. LeTourneau, David R. Gang, Ian T. Paulsen, David M. Weller, Linda S. Thomashow, Alex S. Flynt, Dmitri V. Mavrodi
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Plants live in association with microorganisms that positively influence plant development, vigor, and fitness in response to pathogens and abiotic stressors. The bulk of the plant microbiome is concentrated belowground at the plant root-soil interfa
Externí odkaz:
https://doaj.org/article/7e6deb9844724eac91dcb4f428d8f216
Autor:
Liping Li, Karl A. Hassan, Sasha G. Tetu, Varsha Naidu, Alaska Pokhrel, Amy K. Cain, Ian T. Paulsen
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Tigecycline, a protein translation inhibitor, is a treatment of last resort for infections caused by the opportunistic multidrug resistance human pathogen Acinetobacter baumannii. However, strains resistant to tigecycline were reported not long after
Externí odkaz:
https://doaj.org/article/b0582985213a4cd0921904a37ee9a2fd
Autor:
Daniel Bouzo, Nural N. Cokcetin, Liping Li, Giulia Ballerin, Amy L. Bottomley, James Lazenby, Cynthia B. Whitchurch, Ian T. Paulsen, Karl A. Hassan, Elizabeth J. Harry
Publikováno v:
mSystems, Vol 5, Iss 3 (2020)
ABSTRACT Manuka honey has broad-spectrum antimicrobial activity, and unlike traditional antibiotics, resistance to its killing effects has not been reported. However, its mechanism of action remains unclear. Here, we investigated the mechanism of act
Externí odkaz:
https://doaj.org/article/ec67c9afc5a84423ba54cfab3cb5d039