Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Karl A Nath"'
Autor:
Silvana B De Lorenzo, Alyssa M Vrieze, Ruth A Johnson, Karen R Lien, Karl A Nath, Vesna D Garovic, Khashayarsha Khazaie, Joseph P Grande
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266454 (2022)
Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways. Despite extensive research, progress in identifying therapeutic targets to arrest or slow progre
Externí odkaz:
https://doaj.org/article/9eb2349e87b449389dd73b2b8d888d0a
Autor:
John D Belcher, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, Hao Nguyen, Phong Nguyen, Trevor Killeen, Sylvia M Miescher, Nathan Brinkman, Karl A Nath, Clifford J Steer, Gregory M Vercellotti
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196455 (2018)
During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states. Hapt
Externí odkaz:
https://doaj.org/article/37b25741c6b04581bd4abeec6a919507
Autor:
Gregory M Vercellotti, Fatima B Khan, Heather eBechtel, Karl A Nath, Julia eNguyen, Chunseng eChen, Carol M Bruzzone, Graham eBrown, Clifford John Steer, Robert P Hebbel, John D. Belcher
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transge
Externí odkaz:
https://doaj.org/article/818bdb5b83664b42959d0b07bf3174a3
Autor:
Kathryn T. delValle, Michael J. Krowka, Carrie A. Schinstock, Karl A. Nath, Charles D. Burger, Yogesh N. Reddy, Robert P. Frantz, Y. S. Prakash, Hilary M. DuBrock
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Pulmonary hypertension (PH) associated with chronic kidney disease (CKD) (PH‐CKD) affects approximately 20%–40% of CKD patients and is associated with increased morbidity and mortality. PH and CKD are both pathophysiologically associated
Externí odkaz:
https://doaj.org/article/13ff566423274794ba828f545f932864
Autor:
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expres
Externí odkaz:
https://doaj.org/article/af1307b64c1b4419953e38f85ed47944
Autor:
Sonja Suvakov, Ranine Ghamrawi, Hajrunisa Cubro, Haitao Tu, Wendy M. White, Yvonne S. Butler Tobah, Natasa M. Milic, Joseph P. Grande, Julie M. Cunningham, Fouad T. Chebib, Larissa G.P. Langhi Prata, Yi Zhu, Tamara Tchkonia, James L. Kirkland, Karl A. Nath, Aleksandar Milosavljevic, Vesna D. Garovic
Publikováno v:
EBioMedicine, Vol 70, Iss , Pp 103536- (2021)
Background: Preeclampsia is a pregnancy-specific hypertensive disorder characterized by proteinuria and/or multisystem involvement. Disease-specific therapy has yet to be developed due to the lack of understanding of underlying mechanism(s). We postu
Externí odkaz:
https://doaj.org/article/2d6a2d2b00854797803a0525e383c515
Autor:
Karl A. Nath, Vesna D. Garovic
Publikováno v:
Mayo Clinic Proceedings. 98:509-512
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::206250c1a34166c9b4e6f30e855509a3
https://doi.org/10.1016/j.mayocp.2023.02.006
https://doi.org/10.1016/j.mayocp.2023.02.006
Autor:
Sanjeev Sethi, Benjamin Madden, Marta Casal Moura, Raman Deep Singh, Samih H. Nasr, Jean Hou, Alok Sharma, Karl A. Nath, Ulrich Specks, Fernando C. Fervenza, Mark Haas
Publikováno v:
Journal of the American Society of Nephrology. 34:374-384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39522049ae8f2af2669fbcbb7eaf50af
https://doi.org/10.1681/asn.0000000000000061
https://doi.org/10.1681/asn.0000000000000061
Autor:
Karl A. Nath
Publikováno v:
Mayo Clinic Proceedings. 98:641-643
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee965188844d8d000920e7e71a78a1f
https://doi.org/10.1016/j.mayocp.2023.03.018
https://doi.org/10.1016/j.mayocp.2023.03.018
Autor:
Karl A. Nath
Publikováno v:
Mayo Clinic Proceedings. 98:497-499
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd83f796bba9ecf4fe6fdf3e856f0f8
https://doi.org/10.1016/j.mayocp.2023.02.021
https://doi.org/10.1016/j.mayocp.2023.02.021