Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Karl‐Heinz Thierauch"'
Autor:
Dieter Zopf, Iduna Fichtner, Ajay Bhargava, Wolfram Steinke, Karl‐Heinz Thierauch, Konstanze Diefenbach, Scott Wilhelm, Frank‐Thorsten Hafner, Michael Gerisch
Publikováno v:
Cancer Medicine, Vol 5, Iss 11, Pp 3176-3185 (2016)
Abstract Regorafenib is an orally administered inhibitor of protein kinases involved in tumor angiogenesis, oncogenesis, and maintenance of the tumor microenvironment. Phase III studies showed that regorafenib has efficacy in patients with advanced g
Externí odkaz:
https://doaj.org/article/16c86fc82aff40a3b594ce21968b89fc
Autor:
Peter Ellinghaus, Robert Adams, Tina Müller, Dieter Zopf, Jens Hoffmann, Scott Wilhelm, André Rosenthal, Roberta Schmieder, Arne Scholz, Ajay Bhargava, Karl-Heinz Thierauch, Michael Becker, Nicole Kahmann
Publikováno v:
International Journal of Cancer. Journal International du Cancer
Regorafenib, a novel multikinase inhibitor, has recently demonstrated overall survival benefits in metastatic colorectal cancer (CRC) patients. Our study aimed to gain further insight into the molecular mechanisms of regorafenib and to assess its pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee356bfdfe7ad14e3418d137de948b3
http://europepmc.org/articles/PMC4277327
http://europepmc.org/articles/PMC4277327
Autor:
Ingo Flamme, Iring Heisler, Michael Haerter, Peter Ellinghaus, Alexander Ehrmann, Susanne Greschat, Felix Oehme, Hartmut Beck, Martin Michels, Holger Summer, Karl Ziegelbauer, Holger Hess-Stumpp, Karl-Heinz Thierauch, Kerstin Unterschemmann
Publikováno v:
Cancer Medicine
The activation of the transcription factor hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development, tumor progression, and resistance to chemo- and radiotherapy. In order to identify compounds targeting the HIF pathway, a smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4174a861d462f2de1915952cca5fb3aa
https://doi.org/10.1002/cam4.112
https://doi.org/10.1002/cam4.112
Publikováno v:
Targeted Oncology. 6:155-162
Serum lactate dehydrogenase (LDH) is a well-known clinical surrogate parameter. A high activity of LDH is associated with a poor prognosis in different tumor types. Here we demonstrate by a gene silencing approach that LDH-A is critical for in vivo b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf01017323eadfd875f84adc618d45dc
https://doi.org/10.1007/s11523-011-0184-7
https://doi.org/10.1007/s11523-011-0184-7
Autor:
Falk Fahrenholz, Karl-Heinz Thierauch
Publikováno v:
International Journal of Peptide and Protein Research. 15:323-330
For the synthesis of p-azidophenylalanine peptides, the p-amino group of p-amino-L-phenylalanine is protected with the Z- or Boc residue via the copper complex or by specific acylation at pH 4.6. The alpha-amino or alpha-carboxy group is blocked by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13602cd32ac17fd2c1abd8a9ca93ed65
https://doi.org/10.1111/j.1399-3011.1980.tb02908.x
https://doi.org/10.1111/j.1399-3011.1980.tb02908.x
Autor:
Karl-Heinz Thierauch
Publikováno v:
Encyclopedia of Cancer ISBN: 9783642278419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa79e86daa6f13ff359a6bbcefb961c
https://doi.org/10.1007/978-3-642-27841-9_5374-2
https://doi.org/10.1007/978-3-642-27841-9_5374-2
Autor:
Anette Sommer, Stefan Taudien, Alexander Herr, Karl-Heinz Thierauch, Anke Stein, Jens Glienke, Gunda Herberth, Irina Klaman
Publikováno v:
American Journal of Biochemistry and Biotechnology. 1:135-144
Latrophilin-2 is a member of the family of adhesion-GPCRs that is characterised by a long N-terminus which contains motifs identified in proteins involved in cell adhesion. We were interested in determining the expression pattern of human latrophilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f351dcdfc5a0fc0e96be438d1126bf3
https://doi.org/10.3844/ajbbsp.2005.135.144
https://doi.org/10.3844/ajbbsp.2005.135.144
Publikováno v:
Mechanisms of Development. 96:91-99
Growth factor signalling pathways and their inhibitors coordinate the formation of three-dimensional patterns of vertebrates and invertebrates. Temporal and spatial restriction of the response to a few well-defined cells is crucial and needs the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c335ac53e879c2680c8a8aecfdc35c2d
https://doi.org/10.1016/s0925-4773(00)00378-6
https://doi.org/10.1016/s0925-4773(00)00378-6
Autor:
Bertram Weiß, Karl-Heinz Thierauch, Bernd Hinzmann, Christian Pilarsky, André Rosenthal, Armin Schmitt, Jens Glienke
Publikováno v:
European Journal of Biochemistry. 267:2820-2830
Angiogenesis is a complex process that can be regarded as a series of sequential events comprising a variety of tissue cells. The major problem when studying angiogenesis in vitro is the lack of a model system mimicking the various aspects of the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6562ce897dc718ccca3959182309b7c
https://doi.org/10.1046/j.1432-1327.2000.01325.x
https://doi.org/10.1046/j.1432-1327.2000.01325.x
Autor:
Peter Ellinghaus, Karl-Heinz Thierauch, Ajay Bhargava, Holger Hess-Stumpp, Hartmut Beck, Susanne Greschat-Schade, Stephen Boyer, Kerstin Unterschemmann, Michael Härter
Publikováno v:
ChemMedChem. 9(1)
The transcription factors hypoxia-inducible factor-1 and -2 (HIF-1 and HIF-2) orchestrate a multitude of processes that allow tumor cells to survive under conditions of low oxygen and nutrients, and that lead to resistance to some apoptotic pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7355e925a423b50d576aac338be6f5f2
https://pubmed.ncbi.nlm.nih.gov/24285584
https://pubmed.ncbi.nlm.nih.gov/24285584