Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Karjalainen Arto Johannes"'
Autor:
Arto Tolvanen, Jouko Yliruusi, Saara Tiittanen, Karjalainen Arto Johannes, Mäkelä Mikko, David Din Belle, Veli Pekka Tanninen, Anna Shevchenko, Jorma Haarala, Inna Miroshnyk
Publikováno v:
Organic Process Research & Development. 15:666-672
The need for effective solid-form screening approaches, especially designed for the early discovery phases, is well recognized within the pharmaceutical industry. Here we report on the early polymorphism and solvatomorphism evaluation of a new drug c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e7ec0bf8e5c63090aedac750bf1c973
https://doi.org/10.1021/op200026f
https://doi.org/10.1021/op200026f
Publikováno v:
University of Helsinki
Yli-Kauhaluoma, J, Laine, A, Ratilainen, J & Karjalainen, A 2005, ' Synthesis of benzobicyclo[2.2.1]heptylimidazoles as conformationally constrained adrenergic receptor antagonists ', Heterocycles, vol. 65, no. 11, pp. 2783-2790 . https://doi.org/10.3987/COM-05-10535
Yli-Kauhaluoma, J, Laine, A, Ratilainen, J & Karjalainen, A 2005, ' Synthesis of benzobicyclo[2.2.1]heptylimidazoles as conformationally constrained adrenergic receptor antagonists ', Heterocycles, vol. 65, no. 11, pp. 2783-2790 . https://doi.org/10.3987/COM-05-10535
A facile method for the preparation of conformationally rigid analogues of the adrenergic α-2 receptor antagonist atipamezole and the adrenergic α-2 receptor agonist medetomidine has been developed. The efficient benzyne [4+2] cycloaddition reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8728334bbd5efd8b154161fad3bc6acb
https://cris.vtt.fi/en/publications/b020b455-fb34-49b7-be6a-388ae6259164
https://cris.vtt.fi/en/publications/b020b455-fb34-49b7-be6a-388ae6259164
Autor:
Olavi Pelkonen, Risto Lammintausta, Kalapudas Arja, Marja Södervall, Karjalainen Arto Johannes
Publikováno v:
European Journal of Pharmaceutical Sciences. 11:109-131
A series of long-chained diarylalkylimidazoles and diarylalkyltriazoles were synthesized and evaluated for the inhibitory potency for aromatase (estrogen synthetase) activity in human placental microsomes. The relative specificity of inhibition was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f53fff7e73f99663307699af673f8cd
https://doi.org/10.1016/s0928-0987(00)00074-9
https://doi.org/10.1016/s0928-0987(00)00074-9
Autor:
Reijo Juhani Toivola, Hannu Sundquist, Marja Södervall, Milla Perilä, Sinikka Kallio, Guillermo Blanco, Ilse Pippo, Lauri Kangas, Risto Johansson, Karjalainen Arto Johannes
Publikováno v:
Cancer Chemotherapy and Pharmacology. 17:103-108
The basic pharmacological and biochemical properties of a new antiestrogen, Fc-1157a, are described. Fc-1157a is bound specifically and with high affinity to estrogen receptors. The binding is competitive with estradiol. Fc-1157a treatment induces tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e246402d219c10a88cf2cfdb5fb1698
https://doi.org/10.1007/bf00306736
https://doi.org/10.1007/bf00306736
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 13:59-65
In order to investigate the biotransformation of a new alpha 2-adrenoceptor agonist, detomidine, metabolites were isolated from rat urine by solid phase extraction and purified by TLC. The isolated compounds were structurally analysed by 1H-NMR, MS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cba8e749ada255310af380b0f5d3bfc
https://doi.org/10.1007/bf03189930
https://doi.org/10.1007/bf03189930