Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Karissa Y. Sanbonmatsu"'
Autor:
Vrinda Venu, Cullen Roth, Samantha H. Adikari, Eric M. Small, Shawn R. Starkenburg, Karissa Y. Sanbonmatsu, Christina R. Steadman
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The genome folds into complex configurations and structures thought to profoundly impact its function. The intricacies of this dynamic structure-function relationship are not well understood particularly in the context of viral infection. To
Externí odkaz:
https://doaj.org/article/1f9c4b86b9b745debf3baf5aa53f6f3d
Autor:
Cullen Roth, Vrinda Venu, Vanessa Job, Nicholas Lubbers, Karissa Y. Sanbonmatsu, Christina R. Steadman, Shawn R. Starkenburg
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background Correlation metrics are widely utilized in genomics analysis and often implemented with little regard to assumptions of normality, homoscedasticity, and independence of values. This is especially true when comparing values between
Externí odkaz:
https://doaj.org/article/3cb6da81502f4e049ace1245f25c75d3
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Accurate protein synthesis is determined by the two-subunit ribosome’s capacity to selectively incorporate cognate aminoacyl-tRNA for each mRNA codon. The molecular basis of tRNA selection accuracy, and how fidelity can be affected by anti
Externí odkaz:
https://doaj.org/article/a5e0703efe69456b8f8e549d1ab39eb7
Autor:
Jacob C. Miner, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Karissa Y. Sanbonmatsu, Chang-Shung Tung
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 220-230 (2022)
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and catastrophic, worldwide health and economic impacts. The spike protein on the viral surface is responsible for viral entry into the host cell. The binding of spike protein to the host
Externí odkaz:
https://doaj.org/article/384dded28dd64ff283f79de4aa7b248b
Autor:
Doo Nam Kim, Bernhard C. Thiel, Tyler Mrozowich, Scott P. Hennelly, Ivo L. Hofacker, Trushar R. Patel, Karissa Y. Sanbonmatsu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Many RNA systems possess highly ordered 3-D structures that are essential to their function. Here the authors demonstrate that the long non-coding RNA Braveheart possesses a flexible but defined 3-D structure which is remodeled upon binding the prote
Externí odkaz:
https://doaj.org/article/b7b190fd83ef4f3290654e561d22e685
Autor:
Bin Zhang, Yuntao S. Mao, Sarah D. Diermeier, Irina V. Novikova, Eric P. Nawrocki, Tom A. Jones, Zsolt Lazar, Chang-Shung Tung, Weijun Luo, Sean R. Eddy, Karissa Y. Sanbonmatsu, David L. Spector
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1723-1738 (2017)
The MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) gene encodes a noncoding RNA that is processed into a long nuclear retained transcript (MALAT1) and a small cytoplasmic tRNA-like transcript (mascRNA). Using an RNA sequence- and str
Externí odkaz:
https://doaj.org/article/d062e46877894cd0acc45875f18726f6
Autor:
Jacob C. Miner, Anna Lappala, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Nicolas W. Hengartner, Karissa Y. Sanbonmatsu, Chang-Shung Tung
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 124 (2021)
Seasonal flu is an acute respiratory disease that exacts a massive toll on human populations, healthcare systems and economies. The disease is caused by an enveloped Influenza virus containing eight ribonucleoprotein (RNP) complexes. Each RNP incorpo
Externí odkaz:
https://doaj.org/article/dd2866bbea854faa8d13e4ff9feb6e21
Autor:
Emily J. Hawkes, Scott P. Hennelly, Irina V. Novikova, Judith A. Irwin, Caroline Dean, Karissa Y. Sanbonmatsu
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3087-3096 (2016)
There is considerable debate about the functionality of long non-coding RNAs (lncRNAs). Lack of sequence conservation has been used to argue against functional relevance. We investigated antisense lncRNAs, called COOLAIR, at the A. thaliana FLC locus
Externí odkaz:
https://doaj.org/article/40aa73c0d2a34525b4ac4573a34f318f
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 12, Pp 23672-23684 (2013)
RNAs are important catalytic machines and regulators at every level of gene expression. A new class of RNAs has emerged called long non-coding RNAs, providing new insights into evolution, development and disease. Long non-coding RNAs (lncRNAs) predom
Externí odkaz:
https://doaj.org/article/f9c1d7897bef4da4854c36f0eebd9134
Publikováno v:
Molecules, Vol 22, Iss 9, p 1427 (2017)
Accurate translation of the genetic code depends on mRNA:tRNA codon:anticodon base pairing. Here we exploit an emissive, isosteric adenosine surrogate that allows direct measurement of the kinetics of codon:anticodon University of California base for
Externí odkaz:
https://doaj.org/article/f63a13cc2c9f444586a88a84d0382c06