The trajectory of clinical responses in patients with early rheumatoid arthritis who achieve sustained remission in response to abatacept: subanalysis of AVERT-2, a randomized phase IIIb study

Autor: Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Clifton O. Bingham, Thomas W. J. Huizinga, Gustavo Citera, Kuan-Hsiang Gary Huang, Chun Wu, Sean E. Connolly, Yedid Elbez, Robert Wong, Karissa Lozenski, Roy Fleischmann

Publikováno v: Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)

Abstract Background AVERT-2 (a phase IIIb, two-stage study) evaluated abatacept + methotrexate versus methotrexate alone, in methotrexate-naive, anti-citrullinated protein antibody-positive patients with early (≤ 6 months), active RA. This subanaly

Externí odkaz: https://doaj.org/article/6d0a8a1b51f94829ba8345f63f12219d

Retention of subcutaneous abatacept for the treatment of rheumatoid arthritis: real-world results from the ASCORE study: an international 2-year observational study

Autor: Rieke Alten, Xavier Mariette, René-Marc Flipo, Roberto Caporali, Maya H. Buch, Yusuf Patel, Sara Marsal, Raimon Sanmartí, Michael T. Nurmohamed, Hedley Griffiths, Peter Peichl, Bettina Bannert, Melanie Chartier, Sean E. Connolly, Karissa Lozenski, Christiane Rauch

Publikováno v: Clinical Rheumatology, 41(8), 2361-2373. Springer London
Alten, R, Mariette, X, Flipo, R-M, Caporali, R, Buch, M H, Patel, Y, Marsal, S, Sanmartí, R, Nurmohamed, M T, Griffiths, H, Peichl, P, Bannert, B, Chartier, M, Connolly, S E, Lozenski, K & Rauch, C 2022, ' Retention of subcutaneous abatacept for the treatment of rheumatoid arthritis : real-world results from the ASCORE study: an international 2-year observational study ', Clinical Rheumatology, vol. 41, no. 8, pp. 2361-2373 . https://doi.org/10.1007/s10067-022-06176-1

Objectives To evaluate retention, efficacy, and safety of subcutaneous (SC) abatacept over 2 years in patients with moderate-to-severe RA in the Abatacept SubCutaneOus in Routine clinical practicE (ASCORE) study. Methods Patients with RA who initiate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc06a03c891eaa34278cd818e783090
https://pubmed.ncbi.nlm.nih.gov/35536413

Abasic Phosphorothioate Oligomers Inhibit HIV-1 Reverse Transcription and Block Virus Transmission across Polarized Ectocervical Organ Cultures

Autor: Isaac Zentner, Sharon H. Anderson, Carol Lackman-Smith, Beth A. Snyder, Suhman Chung, Yvonne M. Mueller, Karissa Lozenski, Aidan S Hancock, Irwin Chaiken, Stuart F. J. LeGrice, Deena Ratner, Alina C. Boesteanu, Phalguni Gupta, Marie K. Mankowski, Jennifer L. Hope, Natalie M. Jones, Joseph A. Fraietta, Brian Wigdahl, Peter D. Katsikis

Publikováno v: Antimicrobial Agents and Chemotherapy. 58:7056-7071

In the absence of universally available antiretroviral (ARV) drugs or a vaccine against HIV-1, microbicides may offer the most immediate hope for controlling the AIDS pandemic. The most advanced and clinically effective microbicides are based on ARV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ea90a731f0bacf922f68fdf1d02f37
https://doi.org/10.1128/aac.02991-14

Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety

Autor: Karissa Lozenski, Brian Wigdahl, Fred C. Krebs, Robert T. Ownbey, Tina Kish-Catalone

Publikováno v: BMC Pharmacology & Toxicology

Background The disappointing clinical failures of five topical vaginal microbicides have provided new insights into factors that impact microbicide safety and efficacy. Specifically, the greater risk for human immunodeficiency virus type 1 (HIV-1) ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4e37d6279b59c6263853691f05e7a4
https://doi.org/10.1186/2050-6511-13-9