Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Karishma K. Mehra"'
Autor:
Brooke E. Howitt, Tay Seok Wei, Karishma K. Mehra, Suzy V. Torti, Florian Kern, Debargha Basuli, Lingyan Wu, Mahesh Choolani, Ting Zhang, Molly Brewer, Xia Wang, Niranjan Nagarajan, Yue Hong, Yusuke Yamamoto, Gang Ning, Frank McKeon, Christopher P. Crum, Wa Xian
Publikováno v:
The Journal of Pathology. 238:519-530
High-grade serous cancer (HGSC) progresses to advanced stages without symptoms and the 5-year survival rate is a dismal 30%. Recent studies of ovaries and Fallopian tubes in patients with BRCA1 or BRCA2 mutations have documented a pre-metastatic intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0caaeb5d99fbfd8b28b14c73b639098
https://doi.org/10.1002/path.4649
https://doi.org/10.1002/path.4649
Autor:
Karishma K, Mehra, Daniel P, Petrylak
Publikováno v:
Oncology (Williston Park, N.Y.). 32(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbede1b39ca0ba62c8327d8f8c9fa01e
https://pubmed.ncbi.nlm.nih.gov/29548069
https://pubmed.ncbi.nlm.nih.gov/29548069
Publikováno v:
Advances in Anatomic Pathology. 17:293-302
The fallopian tube has recently emerged as an important site of origin for not only early serous cancer in women with inherited mutations in BRCA1/BRCA2 but as a source of many pelvic serous carcinomas. With this increased attention has come the inev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ed58627fed75ad67804fe6c7fbb8a0
https://doi.org/10.1097/pap.0b013e3181ecdee1
https://doi.org/10.1097/pap.0b013e3181ecdee1
Autor:
Nicholas Monte, Bradley J. Quade, Yosuf Yassin, Christopher P. Crum, Eleanor Y. Chen, George L. Mutter, Wa Xian, Karishma K. Mehra, Gang Ning, Alexander Miron, Mitra Mehrad, Frank McKeon
Publikováno v:
The Journal of Pathology. 222:110-116
The 'p53 signature' is a benign secretory cell outgrowth in the distal Fallopian tube that shares properties with ovarian serous cancer-including p53 mutations-and is a putative serous cancer precursor. We expanded the precursor definition to all sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ea9af0ae91e12da9418eb9f1e699c6
https://doi.org/10.1002/path.2739
https://doi.org/10.1002/path.2739
Autor:
Dana R Semmel, Judy Garber, Esther Oliva, Yosuf Yassin, Alexander Miron, Karishma K. Mehra, Christopher P. Crum, Michael Roh, Annekathryn Goodman, Wa Xian, Ross S. Berkowitz, Bradley J. Quade
Publikováno v:
The Journal of Pathology. 220:17-23
A candidate early precursor to pelvic serous cancer, the 'p53 signature', is commonly found in the benign mucosa of the distal Fallopian tube and harbours p53 mutations and evidence of DNA damage. We examined tubes from women with pre-existing (germ-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1565c2b5f053f1033a35560510e442f1
https://doi.org/10.1002/path.2624
https://doi.org/10.1002/path.2624
Autor:
Wa Xian, Frank McKeon, Karishma K. Mehra, Geng Ning, Christopher P. Crum, Ronny Drapkin, Mitra Mehrad
Publikováno v:
Scopus-Elsevier
The events leading to the most common and most lethal ovarian carcinoma - high grade serous carcinoma - have been poorly understood. However, the detailed pathologic study of asymptomatic women with germ-line BRCA 1 or BRCA2 (BCRA+) mutations has une
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccf6ada865c1f920c909a33a266ae22
https://pubmed.ncbi.nlm.nih.gov/21196340
https://pubmed.ncbi.nlm.nih.gov/21196340
Autor:
Caroline J Raho, Liping Yuan, Karishma K. Mehra, Mitra Mehrad, Aasia Saleemuddin, Ann K. Folkins, Joema Felipe Lima, Martin C. Chang, Shelley S. Tworoger, Christopher P. Crum
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 24(1)
The tubal p53 signature is a putative precursor to pelvic serous carcinoma, but its frequencies in women with inherited mutations in the BRCA1 or BRCA2 genes (BRCA+) and controls has been controversial. An initial section and two levels (100-200 μm)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1317819d16df1a9e00c76df738a8a862
https://pubmed.ncbi.nlm.nih.gov/20871594
https://pubmed.ncbi.nlm.nih.gov/20871594
Autor:
Christopher P. Crum, Xian Wa, Alexander Miron, Yosuf Yassin, Mitra Mehrad, Michelle S. Hirsch, Nicolas M. Monte, George L. Mutter, Frank McKeon, Geng Ning, Michael H. Roh, Karishma K. Mehra, Marisa R. Nucci
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 23(10)
High-grade endometrioid and serous carcinomas of the ovary and fallopian tube are responsible for the majority of cancer deaths and comprise a spectrum that includes early or localized (tubal intraepithelial carcinoma) and advanced (invasive or metas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1490781e617a82f8951adb2333e767ce
https://pubmed.ncbi.nlm.nih.gov/21886166
https://pubmed.ncbi.nlm.nih.gov/21886166
Autor:
Yosuf Yassin, Nicolas M. Monte, Fabiola Medeiros, Álvaro P. Pinto, Alexander Miron, Christopher P. Crum, Terri Y C Woo, Karishma K. Mehra
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 23(3)
Differentiated vulvar intraepithelial neoplasia is a unique precursor to vulvar squamous cell carcinoma that is typically HPV-negative and frequently associated with nuclear p53 staining. These features imply a mode of pathogenesis involving somatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f24c02a27c93ccbc7e2cdaca28e1c20
https://pubmed.ncbi.nlm.nih.gov/20062014
https://pubmed.ncbi.nlm.nih.gov/20062014
Autor:
Christopher P. Crum, Sunghoon Kim, Vinod Vathipadiekal, Xian Wa, Michael J. Birrer, Karishma K. Mehra
Publikováno v:
Cancer Research. 70:1995-1995
Recent evidence on the “fallopian tube as a site of origin for ovarian tumors” has increased the effort to identify the molecular events associated with initiation and progression of this type of tumor. The aim of this study is to generate a gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8cce08b76db7aea3115b6877bb7ccd9
https://doi.org/10.1158/1538-7445.am10-1995
https://doi.org/10.1158/1538-7445.am10-1995