Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX

Autor: Alastair Magness, Emma Colliver, Katey S. S. Enfield, Claudia Lee, Masako Shimato, Emer Daly, David A. Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T. Hiley, Philip S. Hobson, Febe van Maldegem, James L. Reading, Sergio A. Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type ann

Externí odkaz: https://doaj.org/article/f61b4b8bd2f54cbd9679706490019396

Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers

Autor: Edurne Mugarza, Febe van Maldegem, Jesse Boumelha, Christopher Moore, Sareena Rana, Miriam Llorian Sopena, Philip East, Rachel Ambler, Panayiotis Anastasiou, Pablo Romero-Clavijo, Karishma Valand, Megan Cole, Miriam Molina-Arcas, Julian Downward

Publikováno v: Science Advances, 8(29):eabm8780. American Association for the Advancement of Science
Mugarza, E, van Maldegem, F, Boumelha, J, Moore, C, Rana, S, Llorian Sopena, M, East, P, Ambler, R, Anastasiou, P, Romero-Clavijo, P, Valand, K, Cole, M, Molina-Arcas, M & Downward, J 2022, ' Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers ', Science Advances, vol. 8, no. 29, eabm8780, pp. eabm8780 . https://doi.org/10.1126/sciadv.abm8780

Recently developed KRAS G12C inhibitory drugs are beneficial to lung cancer patients harboring KRAS G12C mutations, but drug resistance frequently develops. Because of the immunosuppressive nature of the signaling network controlled by oncogenic KRAS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eba7ee317fefd79fc260d98ab44b82c
https://research.vumc.nl/en/publications/8bed69b7-11f1-4db0-bb5b-f054048a8ab8

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

Autor: Megan Cole, Jesse Boumelha, Miriam Llorian Sopena, Miriam Molina-Arcas, Panos Anastasiou, Sareena Rana, Christopher I. Moore, Febe van Maldegem, Philip East, Julian Downward, Edurne Mugarza, Karishma Valand, Pablo Romero Clavijo, Rachel Ambler

The recent development and approval of KRASG12C inhibitors promises to change profoundly the clinical management of lung cancer patients harbouring KRASG12C mutations. However, early clinical data indicate that acquired drug resistance can frequently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eebd4728b44a095dd96a3a4fd4745a56
https://doi.org/10.1101/2021.10.18.464819

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

Autor: Febe van Maldegem, Karishma Valand, Megan Cole, Harshil Patel, Mihaela Angelova, Sareena Rana, Emma Colliver, Katey Enfield, Nourdine Bah, Victoria Tsang, Edurne Mugarza, Christopher Moore, Philip Hobson, Dina Levi, Miriam Molina-Arcas, Charles Swanton, Julian Downward

Publikováno v: biorxiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::4e5f42387285a5a1f71573706bdbec6a

Abstract A160: Deep immunoprofiling of mouse lung cancer models in steady state and upon drug treatment

Autor: Karishma Valand, Febe van Maldegem, Philip Hobson, Julian Downward, Deborah R. Caswell, Edurne Mugarza, Victoria Siu Kwan Tsang

Publikováno v: Cancer Immunology Research. 7:A160-A160

With the advancement of immunotherapies for lung cancer, it has become apparent how insufficient our knowledge is surrounding the interactions between the tumor and the immune system. In particular in the context of combining immunotherapy with conve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab956711d845890ead8dfd2b267654d0
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a160