Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Karinel Nieves-Merced"'
Autor:
Andrey S. Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F. McHardy, Somshuvra Mukhopadhyay
Publikováno v:
Toxins, Vol 13, Iss 6, p 424 (2021)
Shiga toxin 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol of cells where they target ribosomes. As retrograde trafficking is essential for disease, inhibiting STx1/STx2 trafficking is therapeutically promising. Recently,
Externí odkaz:
https://doaj.org/article/8e84cdf6d6014652a55ee66b10b0e415
Publikováno v:
Chemical Science. 12:3984-3998
SfmD is a heme-dependent enzyme in the biosynthetic pathway of saframycin A. Here, we present a 1.78 A resolution de novo crystal structure of SfmD, which unveils a novel heme cofactor attached to the protein with an unusual HxnHxxxC motif (n ∼ 38)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d245cf00834b4c0503c60ff781394e52
https://doi.org/10.1039/d0sc06369j
https://doi.org/10.1039/d0sc06369j
Publikováno v:
Chemical Science
SfmD is a heme-dependent enzyme in the biosynthetic pathway of saframycin A. Here, we present a 1.78 Å resolution de novo crystal structure of SfmD, which unveils a novel heme cofactor attached to the protein with an unusual HxnHxxxC motif (n ∼ 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49dd38f87fc1a0fab436a9f63df448ab
https://pubmed.ncbi.nlm.nih.gov/34163669
https://pubmed.ncbi.nlm.nih.gov/34163669