Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Karine Smans"'
Autor:
Veerle W Daniëls, Karine Smans, Ines Royaux, Melanie Chypre, Johannes V Swinnen, Nousheen Zaidi
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106913 (2014)
Increased lipogenesis is a hallmark of a wide variety of cancers and is under intense investigation as potential antineoplastic target. Although brisk lipogenesis is observed in the presence of exogenous lipids, evidence is mounting that these lipids
Externí odkaz:
https://doaj.org/article/81f947670509475f8592aa48a6635747
PDF file, 48KB, Induction of apoptosis in HOP62 and HepG2 cells after ACLY silencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a6977097a7b33cb6cbe1b8daedbb91
https://doi.org/10.1158/1535-7163.22497714
https://doi.org/10.1158/1535-7163.22497714
ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA, which is a vital building block for fatty acid, cholesterol, and isoprenoid biosynthesis. ACLY is upregulated in several types of cancer, and its inhibition induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d2828edb9d9cc00a33cc6f2f4f4e9f
https://doi.org/10.1158/1535-7163.c.6535692.v1
https://doi.org/10.1158/1535-7163.c.6535692.v1
PDF file, 56KB, Reduction in protein expression of ACLY by IPTG-inducible shRNA targeting ACLY in HOP62 and HepG2 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2d9c9a1bdc7d79b45bd92886837ab4
https://doi.org/10.1158/1535-7163.22497720
https://doi.org/10.1158/1535-7163.22497720
PDF file, 27KB, Reduction in mRNA expression of ACLY by IPTG-inducible shRNA targeting ACLY in HOP62 and HepG2 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7aa03aadc7ff57248239bc9bb5d5196
https://doi.org/10.1158/1535-7163.22497723.v1
https://doi.org/10.1158/1535-7163.22497723.v1
PDF file, 59KB, Growth curves for ACLY-knockdown population of PC3M cells with/without Geranylgeranyl pyrophosphate (GGPP) supplementation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b334c8dc21e422b77ca7840392a92e
https://doi.org/10.1158/1535-7163.22497711.v1
https://doi.org/10.1158/1535-7163.22497711.v1
Autor:
Johannes V. Swinnen, Guido Verhoeven, Etienne Waelkens, Karine Smans, Frank Vanderhoydonc, Jelle Machiels, Veerle W. Daniëls, David Waltregny, Paul P. Van Veldhoven, Sebastian Munck, Rita Derua, Leen Timmermans, Katryn Scheys, Koen Brusselmans, Evelien Rysman
Supplementary Figure 5 from De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dee18dbdea38aaeb43cce2861c0dab2
https://doi.org/10.1158/0008-5472.22385492.v1
https://doi.org/10.1158/0008-5472.22385492.v1
Autor:
Johannes V. Swinnen, Guido Verhoeven, Etienne Waelkens, Karine Smans, Frank Vanderhoydonc, Jelle Machiels, Veerle W. Daniëls, David Waltregny, Paul P. Van Veldhoven, Sebastian Munck, Rita Derua, Leen Timmermans, Katryn Scheys, Koen Brusselmans, Evelien Rysman
Supplementary Methods from De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1998a65950d3db2ad5ab1935e285425
https://doi.org/10.1158/0008-5472.22385483.v1
https://doi.org/10.1158/0008-5472.22385483.v1
Autor:
Johannes V. Swinnen, Guido Verhoeven, Etienne Waelkens, Karine Smans, Frank Vanderhoydonc, Jelle Machiels, Veerle W. Daniëls, David Waltregny, Paul P. Van Veldhoven, Sebastian Munck, Rita Derua, Leen Timmermans, Katryn Scheys, Koen Brusselmans, Evelien Rysman
Supplementary Figure 6 from De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272d07723381068ebf8da9f009bb0e84
https://doi.org/10.1158/0008-5472.22385489.v1
https://doi.org/10.1158/0008-5472.22385489.v1