MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice

Autor: Jean A. Boutin, Magali Jullian, Lukasz Frankiewicz, Mathieu Galibert, Philippe Gloanec, Thierry Le Diguarher, Philippe Dupuis, Amber Ko, Laurent Ripoll, Marc Bertrand, Anne Pecquery, Gilles Ferry, Karine Puget

Publikováno v: Molecules, Vol 26, Iss 5, p 1291 (2021)

Melanin-concentrating hormone (MCH) is a 19 amino acid long peptide found in the brain of animals, including fishes, batrachians, and mammals. MCH is implicated in appetite and/or energy homeostasis. Antagonists at its receptor (MCH-R1) could be majo

Externí odkaz: https://doaj.org/article/27505378d23142a9af54bb2688ef4401

Fluorescent Peptide Biosensor for Probing CDK6 Kinase Activity in Lung Cancer Cell Extracts

Autor: Mathieu Galibert, Christophe Blanquart, Morgan Pellerano, Karine Puget, Magali Jullian, Sebastien Diot, Jessica Soamalala, May C. Morris

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2020, Online ahead of print. ⟨10.1002/cbic.202000677⟩
ChemBioChem, 2020, Online ahead of print. ⟨10.1002/cbic.202000677⟩

International audience; CDK6 kinase regulates cell cycle progression in G1, together with CDK4, but has cell-, tissue- and developmentally-distinct functions associated with transcription, angiogenesis and metabolism. Although CDK6 constitutes an att

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af4ae050efbed28bb6babbeb9dbd686
https://doi.org/10.1002/cbic.202000677

MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice

Autor: Marc Bertrand, Anne Pecquery, Mathieu Galibert, Laurent Ripoll, Lukasz Frankiewicz, Magali Jullian, Karine Puget, Gilles Ferry, Philippe Gloanec, Thierry Le Diguarher, Amber Ko, Philippe Dupuis, Jean A. Boutin

Publikováno v: Molecules
Volume 26
Issue 5
Molecules, Vol 26, Iss 1291, p 1291 (2021)

Melanin-concentrating hormone (MCH) is a 19 amino acid long peptide found in the brain of animals, including fishes, batrachians, and mammals. MCH is implicated in appetite and/or energy homeostasis. Antagonists at its receptor (MCH-R1) could be majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c542f40a5cdc62352f63c463d9165d3f

The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release

Autor: Sonia Cantel, Philippe Marin, Jean-Louis Banères, Gilbert Bergé, Karine Puget, Jean Martinez, Charlène Valmalle, Gilles Subra, Anne-Claire Coyne, Céline M'Kadmi, Jérémie Neasta, Jean-Claude Galleyrand, Valérie Daugé, Nicole Bernad, Jacky Marie, Didier Gagne, Eric Carnazzi, Marie-Lou Kemel

Publikováno v: British Journal of Pharmacology. 173:1314-1328

Background and PurposeUsing an in-house bioinformatics programme, we identified and synthesized a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Here, we have studied its biological activity, in vitro and in vivo, and have identified it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::829dd5940fe449315393140624d7c64c
https://doi.org/10.1111/bph.13424

Microwave-Mediated Reduction of Disulfide Bridges with Supported (Tris(2-carboxyethyl)phosphine) as Resin-Bound Reducing Agent

Autor: Amélie Maurras, Guillaume Miralles, Gilles Subra, Pascal Verdié, Karine Puget, Jean Martinez

Publikováno v: ACS Combinatorial Science. 15:169-173

We report on the synthesis and use of a new supported reagent consisting in tris(2-carboxyethyl)phosphine (TCEP) immobilized on hydrophilic PEG based resin beads. Used in conjunction with a 5 min microwave (MW) irradiation, "supported TCEP" reduced d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fc56d1c7f844a6c1adc3e3171594e4
https://doi.org/10.1021/co300104k