Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Karine Mollier"'
1
Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells
Autor: L Poirot, A Gouble, Pierre Charneau, Philippe Souque, J Rivière, J Hauer, Anne-Marie Fischer, F Pâques, J Brochet, Marina Cavazzana, J-P de Villartay, Karine Mollier
Publikováno v: Gene Therapy. 21:529-532
The correction of genetic mutations by homologous recombination is an attractive approach to gene therapy. We used the DNA double-strand breaks introduced by the site-specific endonuclease I-Sce1 as a means of increasing homologous recombination of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35c2a0c98d89aa3ec4278697e3e95c0
https://doi.org/10.1038/gt.2014.20
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2
Lentiviral Vectors Encoding HIV-1 Polyepitopes Induce Broad CTL Responses In Vivo
Autor: Pierre Charneau, Philippe Souque, Olivier Adotevi, François A. Lemonnier, Anne-Sophie Beignon, Karine Mollier, Maria Candela Iglesias
Publikováno v: Molecular Therapy
Molecular Therapy, Cell Press, 2007, 15 (6), pp.1203-10. ⟨10.1038/sj.mt.6300135⟩
Molecular Therapy, 2007, 15 (6), pp.1203-10. ⟨10.1038/sj.mt.6300135⟩
International audience; Lentiviral vectors have been tested as vaccination vectors in anti-tumoral and anti-viral models. They efficiently transduce dendritic cells and stimulate strong T-cell responses against the encoded antigen. However, their cap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd59133fc16bd2534fdd20b67f5e94c
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3
Immunogenic HLA-B*0702-Restricted Epitopes Derived from Human Telomerase Reverse Transcriptase That Elicit Antitumor Cytotoxic T-Cell Responses
Autor: Emmanuelle Boulanger, François Lemonnier, Karine Mollier, Pierre Langlade-Demoyen, Pierre Charneau, Olivier Adotevi, Sylvain Cardinaud, Wolf-Hervé Fridman, Blandine Mignen, Maurizio Zanetti, Christine Neuveut, Eric Tartour
Publikováno v: Clinical Cancer Research. 12:3158-3167
Purpose: The human telomerase reverse transcriptase (hTERT) is considered as a potential target for cancer immunotherapy because it is preferentially expressed in tumor cells. To increase the applicability of hTERT-based immunotherapy, we set out to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db780422ad0465da293ec2b3433219f2
https://doi.org/10.1158/1078-0432.ccr-05-2647
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4
A single immunization with a minute dose of a lentiviral vector-based vaccine is highly effective at eliciting protective humoral immunity against West Nile virus
Autor: Karine Mollier, Pierre Charneau, Philippe Souque, Marie-Pascale Frenkiel, Maria Candela Iglesias, Philippe Desprès
Publikováno v: The Journal of Gene Medicine. 8:265-274
Background Lentiviral vectors, due to their capacity to transduce non-dividing cells, have become precious and worldwide used gene transfer systems. Their ability to efficiently and stably transduce dendritic cells (DCs) has led to their successful u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6756814182bf964945b62a047ee6818
https://doi.org/10.1002/jgm.837
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5
G Protein-Dependent CCR5 Signaling Is Not Required for Efficient Infection of Primary T Lymphocytes and Macrophages by R5 Human Immunodeficiency Virus Type 1 Isolates
Autor: Cédric Blanpain, Pierre Charneau, Genevieve Boulla, Aurore Vidy, José Alcamí, Marc Parmentier, Karine Mollier, Fernando Arenzana-Seisdedos, Ali Amara, Javier García-Pérez, Jean-Louis Virelizier
Publikováno v: Journal of Virology. 77:2550-2558
The requirement of human immunodeficiency virus (HIV)-induced CCR5 activation for infection by R5 HIV type 1 (HIV-1) strains remains controversial. Ectopic CCR5 expression in CD4+-transformed cells or pharmacological inhibition of Gαi proteins coupl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de3ea7e30c77dbcde8be9f4ba2bcf44
https://doi.org/10.1128/jvi.77.4.2550-2558.2003
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6
Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice
Autor: Magalie Dosset, Pierre Langlade-Demoyen, Olivier Adotevi, Karine Mollier, Simon Wain-Hobson, Sylvie Rusakiewicz, Pierre Charneau, Philippe Souque
Publikováno v: Vaccine
Vaccine, Elsevier, 2010, epub ahead of print. ⟨10.1016/j.vaccine.2010.06.071⟩
Vaccine, 2010, epub ahead of print. ⟨10.1016/j.vaccine.2010.06.071⟩
Vaccine, Elsevier, 2010, epub ahead of print. 〈10.1016/j.vaccine.2010.06.071〉
International audience; Over expression of telomerase represents a hallmark of cancer cells and the induction of T cell immunity against this universal tumor antigen have gained promising interest for anticancer immunotherapy. In this study we evalua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e438dde900a67606a21aab5f296d9acf
https://pubmed.ncbi.nlm.nih.gov/20654669
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7
Targeting human telomerase reverse transcriptase (hTERT) with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo
Autor: Olivier Adotevi, Christine Neuveut, Eric Tartour, Simon Wain-Hobson, Magalie Dosset, Wolf-Hervé Fridman, Karine Mollier, Pierre Langlade-Demoyen, Patrice Ravel, Pierre Charneau
Publikováno v: Blood
Blood, American Society of Hematology, 2010, epub ahead of print. ⟨10.1182/blood-2009-11-253641⟩
Blood, 2010, epub ahead of print. ⟨10.1182/blood-2009-11-253641⟩
Blood, American Society of Hematology, 2010, epub ahead of print. 〈10.1182/blood-2009-11-253641〉
The success of active immunotherapy is based on the vaccine's ability to overcome immune tolerance through recalibrating the immune system so that it is able to recognize tumor antigens as foreign rather than self. In this study, we used a lentiviral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f47c8a724816b26fd734987a8df9a98
https://hal-pasteur.archives-ouvertes.fr/pasteur-00460451
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8
Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques
Autor: Julie Rivière, Anne-Sophie Beignon, Christelle Liard, Sandie Munier, Pierre Charneau, Karine Mollier, Frédéric Coutant, Philippe Souque
Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2009, 83 (21), pp.10963-74. ⟨10.1128/JVI.01284-09⟩
Journal of Virology, 2009, 83 (21), pp.10963-74. ⟨10.1128/JVI.01284-09⟩
Journal of Virology, American Society for Microbiology, 2009, 83 (21), pp.10963-74. 〈10.1128/JVI.01284-09〉
AIDS vaccination has a pressing need for more potent vaccination vectors capable of eliciting strong, diversified, and long-lasting cellular immune responses against human immunodeficiency virus (HIV). Lentiviral vectors have demonstrated efficiency
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9563f0f8bddc66f631293c812a87d58f
https://hal-pasteur.archives-ouvertes.fr/pasteur-00457819
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9
Nuclear Import Defect of Human Immunodeficiency Virus Type 1 DNA Flap Mutants Is Not Dependent on the Viral Strain or Target Cell Type
Autor: Pierre Charneau, Sandie Munier, Philippe Souque, Nathalie J. Arhel, Karine Mollier
Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2006, 80 (20), pp.10262-10269. ⟨10.1128/JVI.00974-06⟩
Journal of Virology, 2006, 80 (20), pp.10262-10269. ⟨10.1128/JVI.00974-06⟩
We have previously established, using human immunodeficiency virus type 1 (HIV-1) strain LAI, that the HIV-1 central DNA Flap acts as a cis determinant of viral genome nuclear import. Although the impact of the DNA Flap on nuclear import has already
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc2479afa2b9580c42407de8d53b13e
https://europepmc.org/articles/PMC1617309/
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10
A highly efficient, stable, and rapid approach for ex vivo human liver gene therapy via a FLAP lentiviral vector
Autor: Serban Morosan, Serena Battaglia, Pierre Charneau, Dina Kremsdorf, J. Guilherme Tralhao, Karine Mollier, Carlo Giannini, Hélène Gilgenkrantz, Jacques Emmanuel Guidotti, Laurent Hannoun
Allogenic hepatocyte transplantation or autologous transplantation of genetically modified hepatocytes has been used successfully to correct congenital or acquired liver diseases and can be considered as an alternative to orthotopic liver transplanta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b340941f496b434a3193ed6b0f8d549e
https://hdl.handle.net/10400.4/2187
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