Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karine Litherland"'
Autor:
Elisa Zanini, Nicole Forster-Gross, Felix Bachmann, Adrian Brüngger, Paul McSheehy, Karine Litherland, Karin Burger, Anna C. Groner, Mila Roceri, Luc Bury, Martin Stieger, Nicole Willemsen-Seegers, Jos de Man, Diep Vu-Pham, Helma W. E. van Riel, Guido J. R. Zaman, Rogier C. Buijsman, Laurenz Kellenberger, Heidi A. Lane
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThreonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) are common essential kinases that collaborate in activating the spindle assembly checkpoint (SAC) at the kinetochore, ensuring appropriate chromosome alignment and segregation pr
Externí odkaz:
https://doaj.org/article/cf9a84a3e06f4b3a99f2975a86de17db
Autor:
Mark M. Hahn, Cheryl A. Triplett, Michael S. Anderson, Jennifer I. Smart, Karine Litherland, Stephen Keech, Franziska von Siebenthal, Mark Jones, Andrew J. Phipps, Lisa N. Henning
Publikováno v:
Antibiotics, Vol 12, Iss 8, p 1337 (2023)
Francisella tularensis subspecies tularensis is a category-A biothreat agent that can cause lethal tularemia. Ceftobiprole medocaril is being explored as a medical countermeasure for the treatment of pneumonic tularemia. The efficacy of ceftobiprole
Externí odkaz:
https://doaj.org/article/0aee2b16b62943d1823a125f8b869fcb
Autor:
Rima Snariene, Hans Georg Münch, Anne Smits, Christopher M. Rubino, Arunas Liubsys, Karine Litherland, Tomasz Tomasik, Kamal Hamed, Dace Gardovska, Chi D. Hornik, Mark J Polak, Przemko Kwinta, Veerle Cossey, Sebastian Schröpf, Christine Ruehle, Miroslava Bosheva
Publikováno v:
The Pediatric Infectious Disease Journal
Pediatric infectious disease journal, Philadelphia : Lippincott Williams and Wilkins, 2021, vol. 40, no. 11, p. 997-1003
Pediatric infectious disease journal, Philadelphia : Lippincott Williams and Wilkins, 2021, vol. 40, no. 11, p. 997-1003
Supplemental Digital Content is available in the text.
Background: Ceftobiprole, the active moiety of the prodrug ceftobiprole medocaril, is an advanced-generation, broad-spectrum, intravenous cephalosporin, which is currently approved for the t
Background: Ceftobiprole, the active moiety of the prodrug ceftobiprole medocaril, is an advanced-generation, broad-spectrum, intravenous cephalosporin, which is currently approved for the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ecb74891a20d81e1cb4652bab60ddc
https://doi.org/10.1097/inf.0000000000003296
https://doi.org/10.1097/inf.0000000000003296
Autor:
Karine Litherland, Ping Zhou, Laurenz Kellenberger, Mahmoud Y. M. El-Shemerly, Marc Engelhardt, Stephan Braun, Manuel Häckl, Phil McKernan, Inessa Polyakova, Felix Bachmann, Heidi Lane, Nicole Forster-Gross, Paul M.J. McSheehy, Miryana Dimova-Dobreva
Publikováno v:
Expert opinion on investigational drugs. 30(11)
Introduction This review evaluates the clinical role of fibroblast growth factor receptor 2 (FGFR2) inhibition with derazantinib in patients with intrahepatic cholangiocarcinoma (iCCA) harboring actionable oncogenic FGFR2 fusions/rearrangements, muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c52ecf864adfd03a192a3d5a223c8b
https://pubmed.ncbi.nlm.nih.gov/34698609
https://pubmed.ncbi.nlm.nih.gov/34698609
Autor:
Sebastian Schröpf, Anthony P. Cammarata, Kamal Hamed, Mark J Polak, Karine Litherland, Anne Smits, Christopher M. Rubino
Publikováno v:
Antimicrobial Agents and Chemotherapy
Ceftobiprole is an advanced-generation cephalosporin for intravenous administration with activity against Gram-positive and Gram-negative organisms. A population pharmacokinetic (PK) model characterizing the disposition of ceftobiprole in plasma usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93df92573d8679313762b166f149487a
https://lirias.kuleuven.be/handle/123456789/683977
https://lirias.kuleuven.be/handle/123456789/683977
Autor:
Heidi A. Lane, Felix Bachmann, Elisa Zanini, Paul McSheehy, Karine Litherland, Nicole Forster-Gross, Luc Bury, Diep Vu-Pham, Jos de Man, Wilhelmina E. van Riel, Guido JR Zaman, Rogier C. Buijsman, Laurenz Kellenberger
Publikováno v:
Cancer Research. 82:5645-5645
Background: BAL0891 is a dual inhibitor of threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1). These kinases collaborate in activating the mitotic spindle assembly checkpoint (SAC) at the kinetochore (KT) to regulate chromosome alignment a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa25cb69c841f8bf9e21e1322bc9e14
https://doi.org/10.1158/1538-7445.am2022-5645
https://doi.org/10.1158/1538-7445.am2022-5645
Autor:
Heidi Lane, Malte Kleinschmidt, Elizabeth Ruth Plummer, Sarah Derby, Fatima König, Crescens Diane Tiu, Patrick Roth, Anna Stansfeld, Felix Bachmann, Noor Md Haris, Alexandru C Stan, Marc Engelhardt, Thomas Kaindl, Juanita Lopez, T.R. Jeffry Evans, Joel R. Eisner, Karine Litherland, Liam Welsh, Thomas Hundsberger, Stephanie Anderson
Publikováno v:
Journal of Clinical Oncology. 39:TPS2068-TPS2068
TPS2068 Background: Lisavanbulin (BAL101553, prodrug of BAL27862) is a novel tumor checkpoint controller that promotes tumor cell death by modulating the spindle assembly checkpoint. BAL27862 is a lipophilic, small molecule (MW 387) shown in rodents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::260b325158d6b96bd5a3e19856017003
https://doi.org/10.1200/jco.2021.39.15_suppl.tps2068
https://doi.org/10.1200/jco.2021.39.15_suppl.tps2068
Autor:
Alexandar Tzankov, Rebecca Kristeleit, J. Evans, Heidi Lane, Sabina Berezowska, Paul Mulholland, Igor Vivanco, Ines Figueiredo, Felix Bachmann, Crescens Diane Tiu, Stephanie Anderson, R. Rulach, Thomas Kaindl, Karine Litherland, C. Pognan, Marc Engelhardt, Ruth Plummer, Juanita Lopez, Bora Gurel, N. Md. Haris
Publikováno v:
Annals of Oncology. 31:S404
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::233218d7eae0c9ce1684a919b2821d5e
https://doi.org/10.1016/j.annonc.2020.08.491
https://doi.org/10.1016/j.annonc.2020.08.491
Autor:
Michael Beverly, Jeremy Baryza, Chandra Vargeese, Olivier Heudi, Thomas Faller, Jürg Hunziker, Julien A. Boos, Karine Litherland, Markus Stoeckli, Piet Swart, Keith Bowman, Francois Natt, Iwan Beuvink, Esther van de Kerkhof, Jesper Christensen, Joel Krauser
Publikováno v:
Drug Metabolism and Disposition. 42:431-440
Absorption, distribution, metabolism, and excretion properties of a small interfering RNA (siRNA) formulated in a lipid nanoparticle (LNP) vehicle were determined in male CD-1 mice following a single intravenous administration of LNP-formulated [(3)H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4d9490ba4aec0852d6e9059a6ec750
https://doi.org/10.1124/dmd.113.055434
https://doi.org/10.1124/dmd.113.055434
Autor:
Francois Natt, Thomas Faller, Joel Krauser, Esther van de Kerkhof, Juerg Hunziker, Karine Litherland, Jesper Christensen, Piet Swart
Publikováno v:
Drug Metabolism and Disposition. 41:1211-1219
Absorption, distribution, metabolism, and excretion properties of two unformulated model short interfering RNA (siRNAs) were determined using a single internal [(3)H]-radiolabeling procedure, in which the full-length oligonucleotides were radiolabele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f517889d1de3a0a0211682de90694ec
https://doi.org/10.1124/dmd.112.050666
https://doi.org/10.1124/dmd.112.050666