Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Karine Leclercq"'
1
Akademický článek
Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome
Autor: Stéphane Auvin, Blandine Dozières‐Puyravel, Andreja Avbersek, David Sciberras, Jo Collier, Karine Leclercq, Pavel Mares, Rafal M. Kaminski, Pierandrea Muglia
Publikováno v: Annals of Clinical and Translational Neurology, Vol 7, Iss 3, Pp 343-352 (2020)
Abstract Objective Infantile spasm syndrome (ISS) is an epileptic encephalopathy without established treatment after the failure to standard of care based on steroids and vigabatrin. Converging lines of evidence indicating a role of NR2B subunits of
Externí odkaz: https://doaj.org/article/6e28defa096e430da2342590d5729c98
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2
Akademický článek
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target
Autor: Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura, Seon-Ah Chong, Jacques Behmoaras, Irena Kadiu, Enrico Petretto, Rafal M. Kaminski, Michael R. Johnson
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify
Externí odkaz: https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2f
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3
Akademický článek
Electrical, molecular and behavioral effects of interictal spiking in the rat
Autor: Daniel T. Barkmeier, Danielle Senador, Karine Leclercq, Darshan Pai, Jing Hua, Nash N. Boutros, Rafal M. Kaminski, Jeffrey A. Loeb
Publikováno v: Neurobiology of Disease, Vol 47, Iss 1, Pp 92-101 (2012)
Objective: Epilepsy is a disease characterized by chronic seizures, but is associated with significant comorbidities between seizures including cognitive impairments, hyperactivity, and depression. To study this interictal state, we characterized the
Externí odkaz: https://doaj.org/article/c83e793b253444d984315731821e1dad
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5
Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models
Autor: Henrik Klitgaard, Rafal M. Kaminski, Karine Leclercq, Alain Matagne, Laurent Provins
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 372:11-20
The antiepileptic drug (AED) candidate, (4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one (padsevonil), is the first in a novel class of drugs that bind to synapt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f14e53c3dbce1744c70cdd751dbc9c
https://doi.org/10.1124/jpet.119.261222
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6
Anticonvulsant and antiepileptogenic effects of system xc− inactivation in chronic epilepsy models
Autor: Pamela Maher, Karine Leclercq, Tania Deprez, Hideyo Sato, Ilse Julia Smolders, Rafal M. Kaminski, Catherine Vandenplas, Sylvia Dardenne, Seon-Ah Chong, Patrik Foerch, Ann Massie, Georges Mairet-Coello, Joeri Van Liefferinge, Giulia Albertini, Eduard Bentea, Michel Neveux
Publikováno v: Epilepsia. 60:1412-1423
Objective The cystine/glutamate antiporter system x c - could represent a new target for antiepileptogenic treatments due to its crucial roles in glutamate homeostasis and neuroinflammation. To demonstrate this, we compared epilepsy development and s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b0e6a73024aef0e3e67e42b1c41e1c
https://doi.org/10.1111/epi.16055
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7
Implication of sestrin3 in epilepsy and its comorbidities
Autor: Pietro Marino, Marie Soukoupova, Michele Simonato, Enrico Petretto, Karine Leclercq, Giovanna Paolone, Silvia Zucchini, Rafal Kaminski, Marilyne Labasque, Chiara Falcicchia, Marvin Johnson, Francesca Lovisari, Zoe Webster, Tiziana Rossetti, Ben Moyon, Selene Ingusci, Paolo Roncon
Publikováno v: Brain Communications
Epilepsy is a serious neurological disorder affecting about 1% of the population worldwide. Epilepsy may arise as a result of acquired brain injury, or as a consequence of genetic predisposition. To date, genome-wide association studies and exome seq
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab70ab78c7eaa5547844d2e996a14f5c
http://europepmc.org/articles/PMC7966953
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8
Development of a rat model for glioma-related epilepsy
Autor: Jeroen Verhoeven, Caroline Van den Broecke, Seon-Ah Chong, Karine Leclercq, Christian Vanhove, Charlotte Germonpré, Lucas Jacquin, Ingeborg Goethals, Wytse Wadman, Kristl Vonck, Véronique M. André, Charlotte Bouckaert, Paul Boon, Benedicte Descamps, Robrecht Raedt, Evelien Carrette, Sam Donche, Filip De Vos, Georges Mairet-Coello
Publikováno v: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
International Journal of Molecular Sciences
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 6999, p 6999 (2020)
Seizures are common in patients with high-grade gliomas (30&ndash
60%) and approximately 15&ndash
30% of glioblastoma (GB) patients develop drug-resistant epilepsy. Reliable animal models are needed to develop adequate treatments for glioma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd595d7d20820a53738017bdec2764d7
https://biblio.ugent.be/publication/8675526
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9
Anticonvulsant and antiepileptogenic effects of system
Autor: Karine, Leclercq, Joeri Van, Liefferinge, Giulia, Albertini, Michel, Neveux, Sylvia, Dardenne, Georges, Mairet-Coello, Catherine, Vandenplas, Tania, Deprez, Seon-Ah, Chong, Patrik, Foerch, Eduard, Bentea, Hideyo, Sato, Pamela, Maher, Ann, Massie, Ilse, Smolders, Rafal M, Kaminski
Publikováno v: Epilepsia. 60(7)
The cystine/glutamate antiporter systemMice were surgically implanted with electrodes in the basolateral amygdala and chronically stimulated to develop self-sustained status epilepticus (SSSE); continuous video-electroencephalography monitoring was p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdd3774055647a67f96aa37e804d8162
https://pubmed.ncbi.nlm.nih.gov/31179549
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10
Resveratrol lacks protective activity against acute seizures in mouse models
Autor: Rafal M. Kaminski, Francesca Tomaciello, Karine Leclercq
Publikováno v: Neuroscience Letters. 632:199-203
Resveratrol (3,4',5-stilbenetriol) is a natural product having diverse anti-inflammatory and antioxidant properties. The compound has a wide spectrum of pharmacological and metabolic activity, including cardioprotective, neuroprotective, anticarcinog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab679ff3e90f9c8850f7df1a2c30a04
https://doi.org/10.1016/j.neulet.2016.09.002
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