Výsledky vyhledávání - "Karine Lavrador"

Cutting Edge: Serotonin Is a Chemotactic Factor for Eosinophils and Functions Additively with Eotaxin

Autor: Lyudmila Sikora, Francisco M. Lio, Savita P. Rao, Karine Lavrador, Terlika S. Pandit, P. Sriramarao, Stefen A. Boehme

Publikováno v: The Journal of Immunology. 173:3599-3603

Elevated levels of serotonin (5-hydroxytryptamine, 5-HT) are observed in the serum of asthmatics. Herein, we demonstrate that 5-HT functions independently as an eosinophil chemoattractant that acts additively with eotaxin. 5-HT2A receptor antagonists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6672a3eefa308e02945b90165894300c
https://doi.org/10.4049/jimmunol.173.6.3599

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Synthesis of 1, 4, 5, 6-Tetrahydro 2-Methyl 4-Pyrimidine Carboxylic Acid: Osmoprotector Amino Acid

Autor: Jack Hamelin, Souad Himdi-Kabbab, Jean Pierre Bazureau, Karine Lavrador

Publikováno v: Synthetic Communications. 25:2223-2227

Synthesis of 1, 4, 5, 6-Tetrahydro 2-methyl 4-pyrimidine carboxylic acid (Ectoine) is achieved by thermal cyclization of N-Acetyl diaminobutyric acid, itself synthesized by acetylation of (L) 2,4-diaminobutyric acid.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4918514aa153a21e93c42ca8c337e1fe
https://doi.org/10.1080/00397919508011777

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A screening library for peptide activated G-protein coupled receptors. 1. The test set

Autor: John Saunders, Brian J. Murphy, John P. Williams, Scott Struthers, Karine Lavrador, Xiaochuan Wang

Publikováno v: Journal of medicinal chemistry. 47(27)

One subset of the G-protein coupled receptor (GPCR) superfamily is that which is activated by a peptide carrying an obligatory positively charged residue (GPCR-PA(+)). This subclass is exemplified by receptors for melanocortins, GnRH, galanin, MCH, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4979dcc69de3a25550c93cb065ffcb52
https://pubmed.ncbi.nlm.nih.gov/15615535

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A solution-phase combinatorial synthesis of selective dopamine D4 ligands

Autor: Karine Lavrador, John P. Williams

Publikováno v: Combinatorial chemistryhigh throughput screening. 3(1)

Utilizing combinatorial synthesis and a preparative LC-MS automated chromatography system we have prepared and purified a library of 4-[2-(1,2,4-oxadiazolyl)]piperidines that were designed to be novel and selective dopamine D4 ligands. In one round o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9320950f466e620ab5d58969fb0368c2
https://pubmed.ncbi.nlm.nih.gov/10702613

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