Antagonism pattern detection between microRNA and target expression in Ewing's sarcoma.

Autor: Loredana Martignetti, Karine Laud-Duval, Franck Tirode, Gaelle Pierron, Stéphanie Reynaud, Emmanuel Barillot, Olivier Delattre, Andrei Zinovyev

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41770 (2012)

MicroRNAs (miRNAs) have emerged as fundamental regulators that silence gene expression at the post-transcriptional and translational levels. The identification of their targets is a major challenge to elucidate the regulated biological processes. The

Externí odkaz: https://doaj.org/article/11f0bc8dd6654de98c9d6bcd921e229d

Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions

Autor: Julien Vibert, Olivier Saulnier, Céline Collin, Floriane Petit, Kyra J.E. Borgman, Jérômine Vigneau, Maud Gautier, Sakina Zaidi, Gaëlle Pierron, Sarah Watson, Nadège Gruel, Clémence Hénon, Sophie Postel-Vinay, Marc Deloger, Virginie Raynal, Sylvain Baulande, Karine Laud-Duval, Véronique Hill, Sandrine Grossetête, Florent Dingli, Damarys Loew, Jacob Torrejon, Olivier Ayrault, Martin F. Orth, Thomas G.P. Grünewald, Didier Surdez, Antoine Coulon, Joshua J. Waterfall, Olivier Delattre

Publikováno v: Molecular Cell. 82:2458-2471.e9

Many cancers are characterized by gene fusions encoding oncogenic chimeric transcription factors (TFs) such as EWS::FLI1 in Ewing sarcoma (EwS). Here, we find that EWS::FLI1 induces the robust expression of a specific set of novel spliced and polyade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985d065fa87a1cf3dab58e6e739e0914
https://doi.org/10.1016/j.molcel.2022.04.019

STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma

Autor: Virginie Raynal, Franck Tirode, Erika Brunet, Thomas Vourc'h, Gaëlle Pierron, Sandrine Grossetête, Sakina Zaidi, Didier Surdez, Anna Sole Ferre, Sylvain Baulande, Lieke Mous, Olivier Delattre, Véronique Hill, Karine Laud-Duval

Publikováno v: Cancer Cell

STAG2, a cohesin family gene, is among the most recurrently mutated genes in cancer. STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a childhood cancer driven by aberrant transcription induced by the EWSR1-FLI1 f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfbb71eddc870bc6622222a847e5dcf
https://doi.org/10.1016/j.ccell.2021.04.001

Oncostatin M Is a Growth Factor for Ewing Sarcoma

Autor: Pierre J. Guihard, Marie F. Heymann, Franck Tirode, Frédéric Blanchard, Karine Laud, Olivier Delattre, Emmanuelle David, Marc Baud'huin, Françoise Rédini, Dominique Heymann

Publikováno v: American Journal of Pathology
American Journal of Pathology, American Society for Investigative Pathology, 2012, 181 (5), pp.1782-1795. ⟨10.1016/j.ajpath.2012.07.023⟩
American Journal of Pathology, 2012, 181 (5), pp.1782-1795. ⟨10.1016/j.ajpath.2012.07.023⟩

International audience; Primary bone tumors, osteosarcomas and chondrosarcomas, derive from mesenchymal stem cells committed into osteoblasts and chondrocytes; in Ewing sarcomas (ESs), the oncogenic fusion protein EWS-FLI1 prevents mesenchymal differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db5f46703ed075ef857b3fed6bedbbd
https://doi.org/10.1016/j.ajpath.2012.07.023

EWS-FLI1 inhibits TNFα-induced NFκB-dependent transcription in Ewing sarcoma cells

Autor: Christian Auclair, Franck Tirode, Olivier Delattre, Alain Lilienbaum, Julie Lagirand-Cantaloube, Marie-Hélène Kryszke, Karine Laud

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2010, 399 (4), pp.705-10. ⟨10.1016/j.bbrc.2010.08.004⟩
Biochemical and Biophysical Research Communications, Elsevier, 2010, 399 (4), pp.705-10. 〈10.1016/j.bbrc.2010.08.004〉

International audience; Ewing sarcoma is primarily caused by a t(11;22) chromosomal translocation encoding the EWS-FLI1 fusion protein. To exert its oncogenic function, EWS-FLI1 acts as an aberrant transcription factor, broadly altering the gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941e3a632b3037b2f736a357273979c4
https://doi.org/10.1016/j.bbrc.2010.08.004