Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Karine Grisendi"'
Autor:
Loïc Dayon, Johannes Voegel, Bruno Mehul, Karine Grisendi, Agnès Perrin, Antonio Núñez Galindo, Corinne Ménigot, Yves Rival
Publikováno v:
Journal of Proteomics. 187:126-143
Histone deacetylases (HDACs) are key enzymes involved in epigenetic modulation and were targeted by HDAC inhibitors (HDACis) for cancer treatment. The action of HDACis is not restricted to histones and also prevents deacetylation of other proteins, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dac15383f3480bc6397447eee2341a
https://doi.org/10.1016/j.jprot.2018.07.003
https://doi.org/10.1016/j.jprot.2018.07.003
Autor:
Catherine Soulet, Laurent F. Hennequin, Nicolas Fleury-Brégeot, Craig S. Harris, Blanche Gauthier, Gwenaëlle Duvert, Etienne Thoreau, Laurent Chantalat, Karine Grisendi, Jean-François Fournier, Jerome Aubert, Michèle Aurelly, Rémy Morgentin, Claire Bouix-Peter, Bénédicte Drean, Guillaume Lafitte, Yushma Bhurruth-Alcor, Florence Joly, Jonathan Pascau, Branislav Musicki, Yves Rival, David Piwnica, Karinne Bouquet, Marion Delorme, T. Isabet, Corinne Millois, Loïc Tomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2985-2992
A series of squaramide-based hydroxamic acids were designed, synthesized and evaluated against human HDAC enzyme. Squaramides were found to be potent in the Hut78 cell line, but initially suffered from low solubility. Leads with improved solubility a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8fc3308da8740d4b656640fc1c579f
https://doi.org/10.1016/j.bmcl.2018.06.029
https://doi.org/10.1016/j.bmcl.2018.06.029