Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Karine Gloux"'
Autor:
Clara Lambert, Marine Gaillard, Paprapach Wongdontree, Caroline Bachmann, Antoine Hautcoeur, Karine Gloux, Thomas Guilbert, Celine Méhats, Bastien Prost, Audrey Solgadi, Sonia Abreu, Muriel Andrieu, Claire Poyart, Alexandra Gruss, Agnes Fouet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract In Streptococcus pyogenes, the type II fatty acid (FA) synthesis pathway FASII is feedback-controlled by the FabT repressor bound to an acyl-Acyl carrier protein. Although FabT defects confer reduced virulence in animal models, spontaneous f
Externí odkaz:
https://doaj.org/article/7f491b6bc68941ea8141f6da9848c69d
Autor:
Filipe Carvalho, Alexis Carreaux, Anna Sartori-Rupp, Stéphane Tachon, Anastasia D. Gazi, Pascal Courtin, Pierre Nicolas, Florence Dubois-Brissonnet, Aurélien Barbotin, Emma Desgranges, Matthieu Bertrand, Karine Gloux, Catherine Schouler, Rut Carballido-López, Marie-Pierre Chapot-Chartier, Eliane Milohanic, Hélène Bierne, Alessandro Pagliuso
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Stressed bacteria can enter a dormant viable but non-culturable (VBNC) state. VBNC pathogens pose an increased health risk as they are undetectable by growth-based techniques and can wake up back into a virulent state. Although widespread in
Externí odkaz:
https://doaj.org/article/229e3ab66ffa43f7bd76311298fe2e08
Autor:
Paprapach Wongdontree, Aaron Millan-Oropeza, Jennifer Upfold, Jean-Pierre Lavergne, David Halpern, Clara Lambert, Adeline Page, Gérald Kénanian, Christophe Grangeasse, Céline Henry, Agnès Fouet, Karine Gloux, Jamila Anba-Mondoloni, Alexandra Gruss
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109505- (2024)
Summary: Antibiotics inhibiting the fatty acid synthesis pathway (FASII) of the major pathogen Staphylococcus aureus reach their enzyme targets, but bacteria continue growth by using environmental fatty acids (eFAs) to produce phospholipids. We asses
Externí odkaz:
https://doaj.org/article/f6bf5f3ca6be4f448560f85bfcc04fd3
Autor:
Clara Lambert, Thifaine Poullion, Qiufen Zhang, Alain Schmitt, Jean-Marc Masse, Karine Gloux, Claire Poyart, Agnès Fouet
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284402 (2023)
Membranes contain lipids that are composed of fatty acids (FA) and a polar head. Membrane homeostasis is crucial for optimal bacterial growth and interaction with the environment. Bacteria synthesize their FAs via the FASII pathway. Gram-positive bac
Externí odkaz:
https://doaj.org/article/007ea901d69b440fa05abd4a93457e93
Autor:
Amit Pathania, Jamila Anba-Mondoloni, Myriam Gominet, David Halpern, Julien Dairou, Laëtitia Dupont, Gilles Lamberet, Patrick Trieu-Cuot, Karine Gloux, Alexandra Gruss
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Staphylococcus aureus
Externí odkaz:
https://doaj.org/article/cfec7281be284fa7a98f1d826099d4d4
Autor:
Gérald Kénanian, Claire Morvan, Antonin Weckel, Amit Pathania, Jamila Anba-Mondoloni, David Halpern, Marine Gaillard, Audrey Solgadi, Laetitia Dupont, Céline Henry, Claire Poyart, Agnès Fouet, Gilles Lamberet, Karine Gloux, Alexandra Gruss
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3974-3982.e4 (2019)
Summary: The essentiality of fatty acid synthesis (FASII) products in the human pathogen Staphylococcus aureus is the underlying rationale for FASII-targeted antimicrobial drug design. Reports of anti-FASII efficacy in animals support this choice. Ho
Externí odkaz:
https://doaj.org/article/b5cad4a0e4ec4316bfa82390590c6c71
Autor:
Claire Morvan, David Halpern, Gérald Kénanian, Constantin Hays, Jamila Anba-Mondoloni, Sophie Brinster, Sean Kennedy, Patrick Trieu-Cuot, Claire Poyart, Gilles Lamberet, Karine Gloux, Alexandra Gruss
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. Here, Morvan et al. show that exogenous fatty acids can favour the emergence of staphylococcal strains displaying resistance to mu
Externí odkaz:
https://doaj.org/article/e8d21997597244098908c235c4491102
Autor:
Karine Gloux, Jamila Anba-Mondoloni
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0148291 (2016)
Crohn's disease, an incurable chronic inflammatory bowel disease, has been attributed to both genetic predisposition and environmental factors. A dysbiosis of the gut microbiota, observed in numerous patients but also in at least one hundred unaffect
Externí odkaz:
https://doaj.org/article/659c1a61cb5743c2b5b0e5f4e393b4c2
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 18, Iss 2, Pp 150-157 (2005)
A negative correlation was observed between the aggressiveness of several Erwinia chrysanthemi strains on potato tuber and their osmotic tolerance. The disruption of the ousA gene encoding the major osmoprotectant uptake system highly enhanced bacter
Externí odkaz:
https://doaj.org/article/917575a6a1874d67a13e6d9ded55e091
Autor:
Omar Lakhdari, Antonietta Cultrone, Julien Tap, Karine Gloux, Françoise Bernard, S Dusko Ehrlich, Fabrice Lefèvre, Joël Doré, Hervé M Blottière
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e13092 (2010)
The human intestinal microbiota plays an important role in modulation of mucosal immune responses. To study interactions between intestinal epithelial cells (IECs) and commensal bacteria, a functional metagenomic approach was developed. One interest
Externí odkaz:
https://doaj.org/article/a13427008f964f168412a56371f7eac6