Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karine Freon"'
Autor:
Julien Hardy, Dingli Dai, Anissia Ait Saada, Ana Teixeira-Silva, Louise Dupoiron, Fatemeh Mojallali, Karine Fréon, Francoise Ochsenbein, Brigitte Hartmann, Sarah Lambert
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008441 (2019)
Replication stress poses a serious threat to genome stability. Recombination-Dependent-Replication (RDR) promotes DNA synthesis resumption from arrested forks. Despite the identification of chromatin restoration pathways after DNA repair, crosstalk c
Externí odkaz:
https://doaj.org/article/965f560ec0c24687a5e588ffa77f36cc
Autor:
Ismail Iraqui, Yasmina Chekkal, Nada Jmari, Violena Pietrobon, Karine Fréon, Audrey Costes, Sarah A E Lambert
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1002976 (2012)
Homologous recombination is a universal mechanism that allows repair of DNA and provides support for DNA replication. Homologous recombination is therefore a major pathway that suppresses non-homology-mediated genome instability. Here, we report that
Externí odkaz:
https://doaj.org/article/1a35279c4cac4ea59df11b26e6ef271b
Autor:
Michaela A Gold, Jenna M Whalen, Karine Freon, Zixin Hong, Ismail Iraqui, Sarah A E Lambert, Catherine H Freudenreich
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009863 (2021)
Disease-associated trinucleotide repeats form secondary DNA structures that interfere with replication and repair. Replication has been implicated as a mechanism that can cause repeat expansions and contractions. However, because structure-forming re
Externí odkaz:
https://doaj.org/article/217d60e344ba4718b05f2866338cb4b1
Autor:
Fouad Ouasti, Maxime Audin, Karine Fréon, Jean-Pierre Quivy, Mehdi Tachekort, Elizabeth Cesard, Aurélien Thureau, Virginie Ropars, Paloma Fernández Varela, Gwenaelle Moal, Ibrahim Soumana-Amadou, Aleksandra Uryga, Pierre Legrand, Jessica Andreani, Raphaël Guerois, Geneviève Almouzni, Sarah Lambert, Francoise Ochsenbein
Publikováno v:
eLife, Vol 12 (2024)
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and functions are st
Externí odkaz:
https://doaj.org/article/e4eaadc73ce04cfaa4c47752fee0fda9
Autor:
Ana Teixeira-Silva, Anissia Ait Saada, Julien Hardy, Ismail Iraqui, Marina Charlotte Nocente, Karine Fréon, Sarah A. E. Lambert
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Terminally arrested replication forks are restarted through homologous recombination after processing single-stranded DNA gaps. Here the authors show that resection is regulated by the NHEJ factor Ku, helping to fine-tune recombination at forks.
Externí odkaz:
https://doaj.org/article/3726da4e581049a5bdae9cbe92ff1eda
Autor:
Violena Pietrobon, Karine Fréon, Julien Hardy, Audrey Costes, Ismail Iraqui, Françoise Ochsenbein, Sarah A E Lambert
Publikováno v:
PLoS Biology, Vol 12, Iss 10, p e1001968 (2014)
At blocked replication forks, homologous recombination mediates the nascent strands to switch template in order to ensure replication restart, but faulty template switches underlie genome rearrangements in cancer cells and genomic disorders. Recombin
Externí odkaz:
https://doaj.org/article/ef4b215e1b334916b42dcb87135b1af6