Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Karine Fabio"'
Autor:
Karine Fabio, Michael J. Brownstein, Shi-fang Lu, Christophe Guillon, Carrie Garippa, Carl Jeffrey Lacey, Neal G. Simon, Ned D. Heindel
Publikováno v:
Journal of Pharmaceutical Sciences. 102:2033-2043
SRX246 is a potent, highly selective, orally bioavailable vasopressin 1a receptor antagonist that represents a novel mechanism of action for the treatment of mood disorders. The compound previously showed efficacy in animal models of mood disorders a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f4efb839e92eac3417ca281c41a8d2
https://doi.org/10.1002/jps.23495
https://doi.org/10.1002/jps.23495
Autor:
Christophe Guillon, Karine Fabio, Jaya Saxena, Sherri C. Young, Ned D. Heindel, Anna M. Vetrano, Diane E. Heck, Meredith P. Harman, Jeffrey D. Laskin, Mou-Tuan Huang, Robert A. Flowers
Publikováno v:
Journal of Applied Toxicology. 32:135-141
As part of a continuous effort to develop efficient counter measures against sulfur mustard injuries, several unique NSAID prodrugs have been developed and screened for anti-inflammatory properties. Presented herein are three classes of prodrugs whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9044099749d47342427de2b1e89113
https://doi.org/10.1002/jat.1645
https://doi.org/10.1002/jat.1645
Autor:
Michael J. Brownstein, Shi-fang Lu, Karine Fabio, Gary A. Koppel, Marvin J. Miller, Neal G. Simon, Craig F. Ferris, Ned D. Heindel, Carrie Garripa, Christophe Guillon
Publikováno v:
Recent Patents on CNS Drug Discovery. 3:77-93
A compelling case for the potential utility of vasopressin (AVP) antagonists as a novel therapeutic class for the treatment of stress-related affective illness has emerged based on observations in depressed individuals, findings in animal models of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227adc08a3c68d6f77e000555eb575c6
https://doi.org/10.2174/157488908784534586
https://doi.org/10.2174/157488908784534586
Autor:
Jeffrey J. Skelton, Karine Fabio, Robin D. G. Cooper, Robert F. Bruns, Gary A. Koppel, Stephen W. Kaldor, David C. Hunden, Bruce A. Dressman, Michael P. Clay, Mitchell I. Steinberg, Michael J. Brownstein, Neal G. Simon, Christophe Guillon, Craig F. Ferris, Marvin J. Miller, Michael O. Chaney, Shi-fang Lu, Ned D. Heindel
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2054-2080
The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC50 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcea47a4dc266c2aa7647f92ba4147e5
https://doi.org/10.1016/j.bmc.2006.12.031
https://doi.org/10.1016/j.bmc.2006.12.031
Autor:
Benoit Adamo, Kelly Kraft, Brendan Laurenzi, Joseph J. Guarneri, Andrea Leone-Bay, Marshall Grant, Kieran Curley, Karine Fabio, Robin Offord
Publikováno v:
AAPS PharmSciTech. 16(6)
In this work, heat stable dry powders of oxytocin (OT) suitable for delivery by oral inhalation were prepared. The OT dry powders were prepared by spray drying using excipients chosen to promote OT stability including trehalose, isoleucine, polyvinyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab558b18cfdb80397256bdeb3128ecf
https://pubmed.ncbi.nlm.nih.gov/25776985
https://pubmed.ncbi.nlm.nih.gov/25776985
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1724:203-214
We describe the synthesis of new perfluorinated dimerizable detergents which contain a tricationic or tetracationic (linear or branched spermine, respectively) polar head, and report on their cmc, their ability to condense DNA into cationic monomolec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e55e8a20267a97e0dcd3f78dc7edf5
https://doi.org/10.1016/j.bbagen.2005.03.007
https://doi.org/10.1016/j.bbagen.2005.03.007
Autor:
Karine Fabio, Neal G. Simon, Graham B. Jones, Christophe Guillon, Ned D. Heindel, Michael J. Brownstein, Shi-fang Lu, Michael S. Placzek, Carl Jeffrey Lacey, Craig F. Ferris
Publikováno v:
Bioorganicmedicinal chemistry. 20(3)
SRX246 is a potent, highly selective human vasopressin V1a antagonist that crosses the blood–brain barrier in rats. CNS penetration makes SRX246 an ideal candidate for potential radiolabeling and use in visualization and characterization of the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac231336e36bac3fbd34b4ecd5d2ba4f
https://pubmed.ncbi.nlm.nih.gov/22249122
https://pubmed.ncbi.nlm.nih.gov/22249122
Autor:
null Karine Fabio, null Christophe Guillon, null Shi-fang Lu, null Ned D. Heindel, null Marvin Miller, null Craig F. Ferris, null Michael J. Brownstein, null Carrie Gar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1981d4d948070bdfdc02b5b4ec6ae62f
https://doi.org/10.2174/978160805159511001010156
https://doi.org/10.2174/978160805159511001010156
Publikováno v:
Bioconjugate chemistry. 14(2)
We describe the synthesis of a series of alpha-galacto-omega-polyamine double-chain bolaamphiphiles (Gal-CL) and report on the gene transfer mediated with lipoplexes they form either when used in conjunction with DOPE or with pcTG90:DOPE. Lipofection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143270e4768302413a3a0f71d4b487c9
https://pubmed.ncbi.nlm.nih.gov/12643746
https://pubmed.ncbi.nlm.nih.gov/12643746
Autor:
Jacques Greiner, Christophe Di Giorgio, Pierre Vierling, Nicolas Guilloteau, Karine Fabio, Loïc Le Gourriérec
Publikováno v:
Tetrahedron Letters. 50:562-563
A new straightforward solid-phase synthesis of perfluoroalkylated dimerizable detergents used as gene delivery systems is presented. This route using Fmoc-Cys(SASRIN™ _® )-OH resin as solid support affords the target products in almost quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6dd03dbf8fc5fb17749e83f648f43f3
https://doi.org/10.1016/j.tetlet.2008.11.072
https://doi.org/10.1016/j.tetlet.2008.11.072