Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Karine F. Santos"'
Publikováno v:
J Biol Chem
The RNA helicase bad response to refrigeration 2 homolog (BRR2) is required for the activation of the spliceosome before the first catalytic step of RNA splicing. BRR2 represents a distinct subgroup of Ski2-like nucleic acid helicases whose members c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f3eedea8e6de60df197f041dfe9f19
https://doi.org/10.1074/jbc.ra119.010964
https://doi.org/10.1074/jbc.ra119.010964
Autor:
Marco Preussner, Karine F. Santos, Jonathan Alles, Christina Heroven, Florian Heyd, Markus C. Wahl, Gert Weber
Publikováno v:
Acta crystallographica / Section D 78(11), 1373-1383 (2022). doi:10.1107/S2059798322009755
Acta crystallographica / Section D 78(11), 1373 - 1383 (2022). doi:10.1107/S2059798322009755
Small nuclear ribonucleoprotein complexes (snRNPs) represent the main subunits of the spliceosome. While the assembly of the snRNP core particles has be
Small nuclear ribonucleoprotein complexes (snRNPs) represent the main subunits of the spliceosome. While the assembly of the snRNP core particles has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c356caa8395e54af49f8fc088c4a8a
Autor:
Sunbin Liu, Sina Mozaffari-Jovin, Jan Wollenhaupt, Karine F Santos, Matthias Theuser, Stanislaw Dunin-Horkawicz, Patrizia Fabrizio, Janusz M Bujnicki, Reinhard Lührmann, Markus C Wahl
Publikováno v:
eLife, Vol 4 (2015)
Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding
Externí odkaz:
https://doaj.org/article/3b0881cfdd874157b3987c784fcd7a22
Autor:
K. Vester, Pohl Milón, Eva Absmeier, Karine F. Santos, Markus C. Wahl, Tahereh Ghane, Marina V. Rodnina, Dmitry Burakovskiy, Petra Imhof
Brr2 is an essential Ski2-like RNA helicase that exhibits a unique structure among the spliceosomal helicases. Brr2 harbors a catalytically active N-terminal helicase cassette and a structurally similar, but enzymatically inactive C-terminal helicase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f824bba7d9e502bb7c5f6b238fdb1aa
https://doi.org/10.1101/2021.01.28.428616
https://doi.org/10.1101/2021.01.28.428616
Autor:
Marina V. Rodnina, K. Vester, Dmitry Burakovskiy, Markus C. Wahl, Pohl Milón, Eva Absmeier, Tahereh Ghane, Petra Imhof, Karine F. Santos
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Brr2 is an essential Ski2-like RNA helicase that exhibits a unique structure among the spliceosomal helicases. Brr2 harbors a catalytically active N-terminal helicase cassette and a structurally similar but enzymatically inactive C-terminal helicase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebde8382e3bb7f7e295d497fb6fcc56
Autor:
Markus C. Wahl, Jana Sticht, Jan Wollenhaupt, Christian Freund, Karine F. Santos, Christian Becke, Lisa M. Henning
Publikováno v:
Biophysical Journal. 114:788-799
Precursor messenger RNA splicing is mediated by the spliceosome, a large and dynamic molecular machine composed of five small nuclear RNAs and numerous proteins. Many spliceosomal proteins are predicted to be intrinsically disordered or contain large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216d57265bb1584bb9e866830d4a8c66
https://doi.org/10.1016/j.bpj.2017.12.033
https://doi.org/10.1016/j.bpj.2017.12.033
RNA helicase Brr2 is required for the activation of the spliceosome prior to the first catalytic step of splicing. Brr2 represents a distinct subgroup of Ski2-like nucleic acid helicases whose members comprise tandem helicase cassettes. Only the N-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd76b7d2ba0e20e1e0b5466c516b37f
https://doi.org/10.1101/758698
https://doi.org/10.1101/758698
Autor:
Karine F. Santos, Marco Di Luccio, J. Vladimir Oliveira, Mirian Cristina Feiten, Débora de Oliveira
Publikováno v:
Applied Biochemistry and Biotechnology. 182:429-451
The study of enzyme function often involves a multi-disciplinary approach. Several techniques are documented in the literature towards determining secondary and tertiary structures of enzymes, and X-ray crystallography is the most explored technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20137683d7e56118eff770b03e58b9
https://doi.org/10.1007/s12010-016-2336-9
https://doi.org/10.1007/s12010-016-2336-9
Publikováno v:
Cell Cycle. 15:3362-3377
Pre-mRNA splicing entails the stepwise assembly of an inactive spliceosome, its catalytic activation, splicing catalysis and spliceosome disassembly. Transitions in this reaction cycle are accompanied by compositional and conformational rearrangement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3d7424146b583ed8341c6851a1551e
https://doi.org/10.1080/15384101.2016.1249549
https://doi.org/10.1080/15384101.2016.1249549
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The Brr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA-protein complex (di-snRNP) during spliceosome activation via ATP-driven translocation on the U4 snRNA strand. However, it is unclear how bound proteins influence U4/U6 unwinding, which reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ccc9e1afc7b403b21df8ae5919818f
https://doi.org/10.1073/pnas.1524616113
https://doi.org/10.1073/pnas.1524616113