Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Karine Dumas"'
Autor:
Marc Cougnon, Romain Carcy, Nicolas Melis, Isabelle Rubera, Christophe Duranton, Karine Dumas, Jean-François Tanti, Catherine Pons, Nicolas Soubeiran, Marina Shkreli, Thierry Hauet, Luc Pellerin, Sébastien Giraud, Nicolas Blondeau, Michel Tauc, Didier F. Pisani
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Inhibition of the eukaryotic initiation factor 5A activation by the spermidine analogue GC7 has been shown to protect proximal cells and whole kidneys against an acute episode of ischaemia. The highlighted mechanism involves a metabolic swit
Externí odkaz:
https://doaj.org/article/1c2ead5a19d749b38f91c58c3d62652c
Autor:
Faustine Pastor, Karine Dumas, Marie-Astrid Barthélémy, Claire Regazzetti, Noémie Druelle, Pascal Peraldi, Mireille Cormont, Jean-François Tanti, Sophie Giorgetti-Peraldi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract In response to endotoxemia, the organism triggers an inflammatory response, and the visceral adipose tissue represents a major source of proinflammatory cytokines. The regulation of inflammation response in the adipose tissue is thus of cruc
Externí odkaz:
https://doaj.org/article/ef7e6eae90454a8ba2c1f73c9ea64b63
Autor:
Jérôme Gilleron, Gwennaëlle Bouget, Stoyan Ivanov, Cindy Meziat, Franck Ceppo, Bastien Vergoni, Mansour Djedaini, Antoine Soprani, Karine Dumas, Arnaud Jacquel, Laurent Yvan-Charvet, Nicolas Venteclef, Jean-François Tanti, Mireille Cormont
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3329-3341.e5 (2018)
Summary: Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the develo
Externí odkaz:
https://doaj.org/article/c2d16480a4704158978b3fd9e7d8c0ad
Autor:
Celine Saint-Laurent, Stephanie Garcia, Vincent Sarrazy, Karine Dumas, Florence Authier, Sophie Sore, Albert Tran, Philippe Gual, Isabelle Gennero, Jean-Pierre Salles, Elvire Gouze
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195876 (2018)
Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been so
Externí odkaz:
https://doaj.org/article/35dc66f3290840868b6ce19b5ac9a2cd
Autor:
Claire Regazzetti, Karine Dumas, Yannick Le Marchand-Brustel, Pascal Peraldi, Jean-François Tanti, Sophie Giorgetti-Peraldi
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52154 (2012)
REDD1 (Regulated in development and DNA damage response 1) is a hypoxia and stress response gene and is a negative regulator of mTORC1. Since mTORC1 is involved in the negative feedback loop of insulin signaling, we have studied the role of REDD1 on
Externí odkaz:
https://doaj.org/article/90d120c1fadd4297b6763bbc94a3f677
Autor:
Florian Britto, Karine Dumas, Vincent Ollendorff, Sophie Giorgetti-Peraldi, François Bertrand Favier
Publikováno v:
American Journal of Physiology-Cell Physiology
American Journal of Physiology-Cell Physiology, American Physiological Society, 2020, 319 (5), pp.C807-C824. ⟨10.1152/ajpcell.00340.2020⟩
American Journal of Physiology-Cell Physiology, American Physiological Society, 2020, 319 (5), pp.C807-C824. ⟨10.1152/ajpcell.00340.2020⟩
The Akt/mechanistic target of rapamycin (mTOR) signaling pathway governs macromolecule synthesis, cell growth, and metabolism in response to nutrients and growth factors. Regulated in development and DNA damage response (REDD)1 is a conserved and ubi
Autor:
Karine Dumas, Pascal Peraldi, Faustine Pastor, Chaima Ayachi, Rodolphe Anty, Sandra Lacas-Gervais, Nathalie Vaillant, Stéphanie Patouraux, Philippe Gual, Albert Tran, Jean-François Tanti, Laurent Yvan-Charvet, Sophie Giorgetti-Peraldi, Mireille Cormont, François Bertrand Favier, Stéphanie Bonnafous, Jerome Gilleron
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (4), pp.5046-5060. ⟨10.1096/fj.201901799RR⟩
FASEB Journal, 2020, 34 (4), pp.5046-5060. ⟨10.1096/fj.201901799RR⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (4), pp.5046-5060. ⟨10.1096/fj.201901799RR⟩
FASEB Journal, 2020, 34 (4), pp.5046-5060. ⟨10.1096/fj.201901799RR⟩
International audience; Nonalcoholic fatty liver disease is a chronic liver disease which is associated with obesity and insulin resistance. We investigated the implication of REDD1 (Regulated in development and DNA damage response-1), a stress-induc
Autor:
Claire Regazzetti, Yannick Le Marchand-Brustel, Philippe Gual, Karine Dumas, Philippe Valet, Pascal Peraldi, Jean-François Tanti, Faustine Pastor, S. Bonnafous, Soazig Le Lay, Sophie Giorgetti-Peraldi, Sandra Lacas-Gervais, Albert Tran, Mireille Cormont, Isabelle Dugail
Publikováno v:
Endocrinology
Endocrinology, Endocrine Society, 2014, pp.en20141656
Endocrinology, Endocrine Society, 2015, 156 (3), pp.789-801. ⟨10.1210/en.2014-1656⟩
Endocrinology, 2015, 156 (3), pp.789-801. ⟨10.1210/en.2014-1656⟩
Endocrinology, Endocrine Society, 2014, pp.en20141656
Endocrinology, Endocrine Society, 2015, 156 (3), pp.789-801. ⟨10.1210/en.2014-1656⟩
Endocrinology, 2015, 156 (3), pp.789-801. ⟨10.1210/en.2014-1656⟩
During obesity, a hypoxic state develops within the adipose tissue, resulting in insulin resistance. To understand the underlying mechanism, we analyzed the involvement of caveolae because they play a crucial role in the activation of insulin recepto
Autor:
Mireille Cormont, Faustine Pastor, Claire Regazzetti, Sophie Giorgetti-Peraldi, Noémie Druelle, Karine Dumas, Pascal Peraldi, Jean-François Tanti, Marie-Astrid Barthélémy
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-07182-z⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-07182-z⟩
In response to endotoxemia, the organism triggers an inflammatory response, and the visceral adipose tissue represents a major source of proinflammatory cytokines. The regulation of inflammation response in the adipose tissue is thus of crucial impor
Autor:
Jennifer Jager, Flavien Berthou, Mireille Cormont, Jean-François Tanti, Franck Ceppo, Karine Dumas
Publikováno v:
Endocrinology. 155:951-964
Adipose tissue inflammation is associated with the development of insulin resistance. In obese adipose tissue, lipopolysaccharides (LPSs) and saturated fatty acids trigger inflammatory factors that mediate a paracrine loop between adipocytes and macr