Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut Symbiont Bacteroides thetaiotaomicron Reveals the First GAG-specific Bacterial Endosulfatase

Autor: Olivier Berteau, Pierre-Alexandre Driguez, Jonathan E. Ulmer, Annie Malleron, Corine Sandström, Eric Morssing Vilén, Ramesh Babu Namburi, Alhosna Benjdia, Julie Beneteau, Karine Descroix, Christine Le Narvor, Lassalle Gilbert, Dorothe Spillmann, David Bonnaffé

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (35), pp.24289-24303. ⟨10.1074/jbc.M114.573303⟩
Journal of Biological Chemistry 35 (289), 24289-24303. (2014)

Background: Sulfatases are emerging as key adaptive tools of commensal bacteria to their host. Results: The first bacterial endo-O-sulfatase and three exo-O-sulfatases from the human commensal Bacteroides thetaiotaomicron, specific for glycosaminogly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04780036118e2b0a8f892598b14a6a55
https://doi.org/10.1074/jbc.m114.573303

ChemInform Abstract: Chemical Synthesis of Oligo-(1→3)-β-D-glucans

Autor: Vincent Ferrières, Karine Descroix, Laurent Legentil, Caroline Nugier-Chauvin, Balla Sylla, Richard Daniellou

Publikováno v: ChemInform. 45

The synthesis of β-(13)-glucans is at present has more than a chemical challenge. The discovery of their biological properties found development for new anti- cancer therapies, the efficient preparation of pure and structurally well-defined β-(1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77d0871751aa542a06d7e300ca0d608f
https://doi.org/10.1002/chin.201421263

Contribution of Biocatalysis to the Synthesis of β-(1,3)-Glucans

Autor: Karine Descroix, Richard Daniellou, Laurent Legentil, Balla Sylla, Caroline Nugier-Chauvin, Vincent Ferrieres

Publikováno v: Beta-Glucan, Structure, Chemistry and Specific Application
Vaclav Vetvicka and Miroslav Novak. Beta-Glucan, Structure, Chemistry and Specific Application, Bentham Science Publishers, pp.102-111, 2013, Biology and Chemistry of Beta Glucan, 978-1-60805-301-8. ⟨10.2174/9781608052608113020007⟩

The lightning progress in the understanding of enzymatic mechanisms, democratization of molecular biology tools and their introduction in chemistry laboratories, the pressure of green chemistry notions leading to the need for alternative sustainable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d435243f5138f336c99ea7c3a5be788c
https://hal.science/hal-00961650

Inhibition of Galactosyltransferases by a Novel Class of Donor Analogues

Autor: Thomas Pesnot, Sebastian S. Gehrke, Karine Descroix, Yayoi Yoshimura, Warren W. Wakarchuk, Monica M. Palcic, Gerd K. Wagner

Galactosyltransferases (GalT) are important molecular targets in a range of therapeutic areas, including infection, inflammation, and cancer. GalT inhibitors are therefore sought after as potential lead compounds for drug discovery. We have recently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2df8a59462b66d08986bb4c4bba1d3
https://doi.org/10.1021/jm201154p

Biological properties of (1 → 3)-β-D-glucan-based synthetic oligosaccharides

Autor: Sujata Saraswat-Ohri, Aruna Vashishta, Frank Jamois, Vincent Ferrières, Vaclav Vetvicka, Jean-Claude Yvin, Karine Descroix

Publikováno v: Journal of Medicinal Food
Journal of Medicinal Food, Mary Ann Liebert, 2011, 14 (4), pp.369-76. ⟨10.1089/jmf.2010.0081⟩
Journal of Medicinal Food, 2011, 14 (4), pp.369-76. ⟨10.1089/jmf.2010.0081⟩

International audience; Despite the fact that β-glucans are well-established immunomodulators, the problems with batch-to-batch heterogeneity remains problematic. The aim of this study was to prepare and evaluate new type of synthetic oligosaccharid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5b12acf1ea0077c1ac01c2cd8e888c
https://hal.archives-ouvertes.fr/hal-00753565