Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Karine Belleville"'
Autor:
Louis Doré-Savard, Valérie Otis, Karine Belleville, Myriam Lemire, Mélanie Archambault, Luc Tremblay, Jean-François Beaudoin, Nicolas Beaudet, Roger Lecomte, Martin Lepage, Louis Gendron, Philippe Sarret
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13774 (2010)
Pre-clinical bone cancer pain models mimicking the human condition are required to respond to clinical realities. Breast or prostate cancer patients coping with bone metastases experience intractable pain, which affects their quality of life. Advance
Externí odkaz:
https://doaj.org/article/511e056e7560415ebdcbf79ef1f1d627
Autor:
Alain Larocque, Louis Gendron, Anthony Regina, Valérie Otis, Emilie Eiselt, Gaoqiang Yang, Karine Belleville, Michel Demeule, Philippe Sarret
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:52-61
The analgesic potency of morphine-6-glucuronide (M6G) has been shown to be 50-fold higher than morphine after intracerebral injection. However, the brain penetration of M6G is significantly lower than morphine, thus limiting its usefulness in pain ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02b8a1707d840bda30350d41af5fe49
https://doi.org/10.1124/jpet.119.263566
https://doi.org/10.1124/jpet.119.263566
Autor:
Karine Belleville, Jean-Michel Longpré, Rebecca L. Brouillette, Magali Chartier, Philippe Sarret, Eric Marsault, Christine E. Mona, Michel Grandbois, Sandrine Lavenus, Élie Besserer-Offroy, Marc Sousbie
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulate the receptor's signaling output. In this proof-of-concept study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0168e199370e8cbce85f7135955b1103
http://arxiv.org/abs/2003.03260
http://arxiv.org/abs/2003.03260
Autor:
Robert Dumaine, Mannix Auger-Messier, Alexandre Murza, Dany Salvail, Eric Marsault, Philippe Sarret, Lounès Haroune, David Coquerel, Jean-Michel Longpré, Xavier Sainsily, Jérôme Côté, Kien Trân, Olivier Lesur, Karine Belleville
Publikováno v:
Journal of Medicinal Chemistry. 61:2266-2277
The apelin receptor generates increasing interest as a potential target across several cardiovascular indications. However, the short half-life of its cognate ligands, the apelin peptides, is a limiting factor for pharmacological use. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba0f72ddee95257ecf56fefaa074bf3
https://doi.org/10.1021/acs.jmedchem.7b01353
https://doi.org/10.1021/acs.jmedchem.7b01353
Autor:
Melisange Roux, Nicolas Beaudet, Alexandre J. Parent, Philippe Sarret, Pascal Tétreault, Karine Belleville, Philippe Goffaux, Jean-Michel Longpré
Publikováno v:
Neuroscience. 315:70-78
Clinical evidences suggest that an imbalance between descending inhibition and facilitation drives the development of chronic pain. However, potential mechanisms promoting the establishment of a persistent pain state and the increased pain vulnerabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f39e91b68f229f9a229b320292e78a
https://doi.org/10.1016/j.neuroscience.2015.11.065
https://doi.org/10.1016/j.neuroscience.2015.11.065
Autor:
Karine Belleville, Anissa Kessai, Philippe Sarret, Pedro Geraldes, David André Barrière, Christophe Noll, Jean-Michel Longpré, André C. Carpentier, Geneviève Roussy, Farah Lizotte, Karyn Kirby, Nicolas Beaudet
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports
Scientific Reports
The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption. Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of streptozotocin (HF/HF/Stz) to emulate the long-term complications of T2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec35caa2505eba8eae59c2194496a4a3
https://doi.org/10.1038/s41598-017-18896-5
https://doi.org/10.1038/s41598-017-18896-5
Publikováno v:
Diabetes. 64:3314-3320
Hepatocyte nuclear factor-1α (HNF1α) is a transcription factor expressed in tissues of endoderm origin. Mutations in HNF1A are associated with maturity-onset diabetes of the young 3 (MODY3). Mice deficient for Hnf1α are hyperglycemic, with their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0734a68e8cbdf24a84248efa8a0284db
https://doi.org/10.2337/db15-0124
https://doi.org/10.2337/db15-0124
Publikováno v:
Biopolymers. 102:297-303
Apelin is the endogenous ligand of APJ, which belongs to the superfamily of G protein-coupled receptors. In recent years, the apelin/APJ system has been detected in many tissues and emerges as a promising target for the treatment of various pathophys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f84bb0ebeb5f501de0397bd150a2c1d8
https://doi.org/10.1002/bip.22498
https://doi.org/10.1002/bip.22498
Autor:
Élie Besserer-Offroy, Karine Belleville, Jean-Michel Longpré, Alain Larocque, Eric Marsault, Anthony Regina, Jean-Paul Castaigne, Philippe Sarret, Alexandre Murza, Carine Thiot, Michel Demeule, Christian Che, Nicolas Beaudet, Richard Béliveau, Jean E. Lachowicz, Pascal Tétreault, Steven L. Gonias, Richard Leduc
Publikováno v:
The Journal of clinical investigation, vol 124, iss 3
Neurotensin (NT) has emerged as an important modulator of nociceptive transmission and exerts its biological effects through interactions with 2 distinct GPCRs, NTS1 and NTS2. NT provides strong analgesia when administered directly into the brain; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c293c73cf29acd515afffe7cc34cc904
https://doi.org/10.1172/jci70647
https://doi.org/10.1172/jci70647
Autor:
Gérard Peyrefitte, Elie Debreuve, Karine Belleville, Nathalie Gential-Joannan, Guillaume SAKI
Cet ouvrage prépare aux matières Biologie-Dermatologie et Cosmétologie du CAP Esthétique-Cosmétique et permet de réviser en s'entraînant, l'ensemble des connaissances du programme. Il est organisé en 4 grandes parties : - Partie 1 : Organisat