Quality of life in Parkinson’s disease improved by apomorphine pump: the OPTIPUMP cohort study

Autor: Luc Defebvre, David Devos, Marc Vérin, Caroline Moreau, Emmanuel Roze, Alexandre Eusebio, Tiphaine Rouaud, Valérie Fraix, Christine Brefel Courbon, Christine Tranchant, Jean-Philippe Azulay, Bertrand Degos, Franck Durif, Karine Andre, Sophie Drapier, François Viallet

Publikováno v: Journal of Neurology
Journal of Neurology, 2016, 263 (6), pp.1111-9. ⟨10.1007/s00415-016-8106-3⟩
Journal of Neurology, Springer Verlag, 2016, 263 (6), pp.1111-9. ⟨10.1007/s00415-016-8106-3⟩

International audience; To report on OPTIPUMP, a cohort study, investigating the impact in real-life clinical settings of continuous subcutaneous apomorphine infusion (CSAI) on the quality of life (HRQoL) of patients with Parkinson’s disease. OPTIP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606b8d8bdb7a86ffff2b80a010d2a737
https://univ-rennes.hal.science/hal-01301510

Abstract A51: Antiproliferative activity of F14512, a novel polyamine-vectorized drug, on multidrug resistant cancer cells

Autor: Karine Andre, Nicolas Guilbaud, Viviane Brel, Laurent Créancier, Marie-Laure Marionneau-Brossard, Jérôme Verdier, Emmanuel Fournier, Yves Guminski, Anna Kruczynski, Vanessa Offrete, Jean-Philippe Annereau

Publikováno v: Clinical Cancer Research. 18:A51-A51

F14512 is a novel vectorized topoisomerase II inhibitor currently in phase I clinical study in AML. Briefly, F14512 combines a polyamine (spermine) chain with an epipodophyllotoxin warhead. An enhanced antitumor effect associated with a large therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f5730bf433b8ff94a1007e1a22d9a73
https://doi.org/10.1158/1078-0432.mechres-a51

Abstract B37: F14512, a polyamine-vectorized anticancer drug, triggers senescence cell death mechanism

Autor: Marie-Laure Marionneau, Laurence Lacastaigneratte, Christian Bailly, Nicolas Guilbaud, Karine Andre, Bruno Gomes, Alain Latil, Isabelle Vandenberghe, Aline Stennevin, Anna Kruczynski, Jerome Rouquet, J-Philippe Annereau, Viviane Brel

Publikováno v: Molecular Cancer Therapeutics. 10:B37-B37

Drugs specifically vectorized to cancer cells may offer a reinforced activity, resulting in an improved therapeutic index. In this context, F14512 exploits the Polyamines Transport System (PTS) to accumulate into cells and exhibits an enhanced anti-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d2da61019561dcd572cc2e030b0a1ad
https://doi.org/10.1158/1535-7163.targ-11-b37

Detection of virulence genes and antimicrobial resistance profiles of Escherichia coli isolates from raw milk and artisanal cheese in Southern Brazil

Autor: Leandro Parussolo, Ricardo Antônio Pilegi Sfaciotte, Karine Andrezza Dalmina, Fernanda Danielle Melo, Ubirajara Maciel Costa, Sandra Maria Ferraz

Publikováno v: Semina: Ciências Agrárias, Vol 40, Iss 1, Pp 163-178 (2019)

The serrano artisanal cheese is a typical product from South region of Brazil, which is produced by skilled cheesemakers using raw milk. The contamination of this food by Escherichia coli has a great impact on public health, since it could threat the

Externí odkaz: https://doaj.org/article/9c28e1d07710408185545b1cf1c454ab

Avaliação do período mínimo de maturação para comercialização do queijo artesanal serrano de Santa Catarina

Autor: Karine Andrezza Dalmina, Leandro Parussolo, Ricardo Antonio Pilegi Sfaciotte, Fernanda Danielle Melo, André Thaler Neto, Sandra Maria Ferraz

Publikováno v: Semina: Ciências Agrárias, Vol 41, Iss 5 (2020)

O queijo artesanal serrano (QAS) é produzido a partir de leite cru, tornando-se um meio propício para a multiplicação de micro-organismos patogênicos. O processo de maturação envolve fatores físicos, químicos e microbiológicos que desfavore

Externí odkaz: https://doaj.org/article/5390c447f1f042a1bb695143e3c9e2de