Incident cancers attributable to using opium and smoking cigarettes in the Golestan cohort studyResearch in context

Autor: Karine Alcala, Hossein Poustchi, Vivian Viallon, Farhad Islami, Akram Pourshams, Alireza Sadjadi, Saeed Nemati, Masoud Khoshnia, Abdolsamad Gharavi, Gholamreza Roshandel, Maryam Hashemian, Sanford M. Dawsey, Christian C. Abnet, Paul Brennan, Paolo Boffetta, Kazem Zendehdel, Farin Kamangar, Reza Malekzadeh, Mahdi Sheikh

Publikováno v: EClinicalMedicine, Vol 64, Iss , Pp 102229- (2023)

Summary: Background: Opium consumption has recently been identified as a carcinogen, but the impact of opium use on cancer burden is unknown. We aimed to evaluate the fraction of cancers that could be attributed to opium use alone and in combination

Externí odkaz: https://doaj.org/article/cb7b0e25dea844fa8e33686f1568dd24

The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.

Autor: Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson

Publikováno v: PLoS Medicine, Vol 18, Iss 9, p e1003786 (2021)

BackgroundExcess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulat

Externí odkaz: https://doaj.org/article/e11457db8ee54250ba74852b65231bb7

Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis

Autor: Xiaoshuang Feng, David C. Muller, Hana Zahed, Karine Alcala, Florence Guida, Karl Smith-Byrne, Jian-Min Yuan, Woon-Puay Koh, Renwei Wang, Roger L. Milne, Julie K. Bassett, Arnulf Langhammer, Kristian Hveem, Victoria L. Stevens, Ying Wang, Mikael Johansson, Anne Tjønneland, Rosario Tumino, Mahdi Sheikh, Mattias Johansson, Hilary A. Robbins

Publikováno v: Feng, X, Muller, D C, Zahed, H, Alcala, K, Guida, F, Smith-Byrne, K, Yuan, J M, Koh, W P, Wang, R, Milne, R L, Bassett, J K, Langhammer, A, Hveem, K, Stevens, V L, Wang, Y, Johansson, M, Tjønneland, A, Tumino, R, Sheikh, M, Johansson, M & Robbins, H A 2023, ' Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis ', EBioMedicine, vol. 92, 104623 . https://doi.org/10.1016/j.ebiom.2023.104623

BackgroundTo evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they can improve prediction of prognosis.MethodsWe measured up to 1159 proteins in blood samples from 708 participants in 6 cohor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6a9343f24ca8cc83a142163520a6f5
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-211165

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Autor: Hilary A Robbins, Karine Alcala, Elham Khodayari Moez, Florence Guida, Sera Thomas, Hana Zahed, Matthew Warkentin, Karl Smith-Byrne, Yonathan Brhane, David Muller, Demetrius Albanes, Melinda C Aldrich, Alan A Arslan, Julie Bassett, Christine D Berg, Qiuyin Cai, Chu Chen, Michael PA Davies, Brenda Diergaarde, John K Field, Neal D Freedman, Wen-Yi Huang, Mikael Johansson, Michael Jones, Woon-Puay Koh, Stephen Lam, Qing Lan, Arnulf Langhammer, Linda M Liao, Geoffrey Liu, Reza Malekzadeh, Roger L Milne, Luis M Montuenga, Thomas Rohan, Howard D Sesso, Gianluca Severi, Mahdi Sheikh, Rashmi Sinha, Xiao-Ou Shu, Victoria L Stevens, Martin C Tammemägi, Lesley F Tinker, Kala Visvanathan, Ying Wang, Renwei Wang, Stephanie J Weinstein, Emily White, David Wilson, Jian-Min Yuan, Xuehong Zhang, Wei Zheng, Christopher I Amos, Paul Brennan, Mattias Johansson, Rayjean J Hung

The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6dbdf41c6b28395a8e345db7c2ed8b1
https://doi.org/10.1101/2022.03.21.22272544

Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom

Autor: Ruth C. Travis, Philip A.J. Crosbie, Rebecca Landy, David R Baldwin, Karine Alcala, Anthony J. Swerdlow, Mattias Johansson, Matthew E.J. Callister, Minouk J. Schoemaker, Hilary A. Robbins, Nicholas J. Wareham

Publikováno v: Robbins, H A, Alcala, K, Swerdlow, A J, Schoemaker, M J, Wareham, N, Travis, R C, Crosbie, P A J, Callister, M, Baldwin, D R, Landy, R & Johansson, M 2021, ' Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom ', British Journal of Cancer, vol. 124, no. 12, pp. 2026-2034 . https://doi.org/10.1038/s41416-021-01278-0
Br J Cancer
British Journal of Cancer

Background The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study has compared the performance of lun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b59499da19a7b8125de2d4b8cf8b5d
https://www.research.manchester.ac.uk/portal/en/publications/comparative-performance-of-lung-cancer-risk-models-to-define-lung-screening-eligibility-in-the-united-kingdom(67a836ac-91e4-4be7-9749-43a4065b2309).html