Výsledky vyhledávání - "Karine, Guitot"

Akademický článek

The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium

Autor: Andrea Frapporti, Caridad Miró Pina, Olivier Arnaiz, Daniel Holoch, Takayuki Kawaguchi, Adeline Humbert, Evangelia Eleftheriou, Bérangère Lombard, Damarys Loew, Linda Sperling, Karine Guitot, Raphaël Margueron, Sandra Duharcourt

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

H3K9me3 and H3K27me3 chromatin silencing marks are usually deposited by different SET-domain proteins. Here the authors show that the Enhancer-of-zeste-like protein Ezl1, from the unicellular eukaryote Paramecium tetraurelia, catalyzes methylation of

Externí odkaz: https://doaj.org/article/a486884fd7c44e3eb795b8444d15483e

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Characterization of SET-Domain Histone Lysine Methyltransferase Substrates Using a Cofactor S-Adenosyl-L-Methionine Surrogate

Autor: Alexandre, Désert, Karine, Guitot, Audrey, Michaud, Daniel, Holoch, Raphaël, Margueron, Fabienne, Burlina, Dominique, Guianvarc'h

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2529

Identification of histone lysine methyltransferase (HKMT) substrates has recently benefited from chemical-biology-based strategies in which artificial S-adenosyl-L-methionine (SAM) cofactors are engineered to allow substrate labeling using either the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8baddfe0282fc190ef1512c47456897
https://pubmed.ncbi.nlm.nih.gov/35733021

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Synthesis of chemical tools to label the mycomembrane of corynebacteria using modified iron( iii ) chloride-mediated protection of trehalose

Autor: Mathieu Carlier, Emilie Lesur, Aurélie Baron, Aurélie Lemétais, Karine Guitot, Loïc Roupnel, Christiane Dietrich, Gilles Doisneau, Dominique Urban, Nicolas Bayan, Jean-Marie Beau, Dominique Guianvarc'h, Boris Vauzeilles, Yann Bourdreux

Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2022, 20 (9), pp.1974-1981. ⟨10.1039/D2OB00107A⟩

Trehalose-based probes are useful tools that allow the detection of the mycomembrane of mycobacteria through the metabolic labeling approach. Trehalose analogues conjugated to fluorescent probes can be used, and other probes are functionalized with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b5548bbcdb982416bdbbf7a2324001
https://hal.science/hal-03801948/document

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Characterization of SET-Domain Histone Lysine Methyltransferase Substrates Using a Cofactor S-Adenosyl-l-Methionine Surrogate

Autor: Alexandre Désert, Karine Guitot, Audrey Michaud, Daniel Holoch, Raphaël Margueron, Fabienne Burlina, Dominique Guianvarc’h

Publikováno v: Histone Methyltransferases ISBN: 9781071624807

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::264d8bb63acbf3af144e3e2e245d5e6f
https://doi.org/10.1007/978-1-0716-2481-4_14

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Introducing the Chiral Constrained α-Trifluoromethylalanine in Aib Foldamers to Control, Quantify and Assign the Helical Screw-Sense

Autor: Lizeth Bodero, Karine Guitot, Nathalie Lensen, Olivier Lequin, Thierry Brigaud, Sandrine Ongeri, Grégory Chaume

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, 2022, 28 (8), pp.e202103887. ⟨10.1002/chem.202103887⟩

International audience; Oligomers of α-aminoisobutyric acid (Aib) are achiral peptides that adopt 310 helical structures with equal population of left- and right-handed conformers. The screw-sense preference of the helical chain may be controlled by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48570add43ab802c2e048ca510f4096
https://pubmed.ncbi.nlm.nih.gov/34890083

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The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium

Autor: Adeline Humbert, Daniel Holoch, Andrea Frapporti, Linda Sperling, Sandra Duharcourt, Evangelia Eleftheriou, Olivier Arnaiz, Takayuki Kawaguchi, Damarys Loew, Caridad Miró Pina, Karine Guitot, Raphaël Margueron, Bérangère Lombard

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.2710. ⟨10.1038/s41467-019-10648-5⟩
Nature Communications, 2019, 10 (1), pp.2710. ⟨10.1038/s41467-019-10648-5⟩

In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries. H3K9me3 is catalyzed by the SET-domain SU(VAR)3–9 enzymes, while H3K27me3 is catalyzed by the SET-domain Enhancer-of-zeste enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991762f65549558bade2ab785ad02908
https://doaj.org/article/a486884fd7c44e3eb795b8444d15483e

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Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation

Autor: Mehdi Amoura, Alain Joliot, John Offer, Karine Guitot, Françoise Illien, Fabienne Burlina, Sandrine Sagan

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2019, 55 (31), pp.4566-4569. ⟨10.1039/C9CC01265F⟩

International audience; A series of cyclic lipidated oligo-Arg cell penetrating peptides were synthesised with varied macrocycle size and lipid chain anchoring site. The study of their cellular uptake revealed different structural requirements to pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2c4b693e22f4eebce67988161c6b76
https://hal.sorbonne-universite.fr/hal-02188663/document

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A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases

Autor: Gérard Bolbach, Robert H. Dodd, Emmanuelle Sachon, Olivier Pamlard, Sandra Beaupierre, Dominique Guianvarc'h, Thierry Drujon, Sandrine Sagan, Fabienne Burlina, Catherine Guillou, Karine Guitot

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, 2017, 409 (15), pp.3767-3777. ⟨10.1007/s00216-017-0319-5⟩

International audience; Histone lysine methylation is associated with essential biological functions like transcription activation or repression, depending on the position and the degree of methylation. This post-translational modification is introdu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb293a7043393dcca9550772d355e5bc
https://pubmed.ncbi.nlm.nih.gov/28389916

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The Combination of Prolinoamino Acids and Cyclopropylamino Acids Leads to Fully Functionalized, Stable β-Turns in Water

Autor: Philippe Bertus, Jean-Luc Vasse, Olivier Lequin, Karine Guitot, Solange Lavielle, Maud Larregola, Tarun K. Pradhan, Philippe Karoyan, Jan Szymoniak

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2011, 12, pp.1039-1042. ⟨10.1002/cbic.201000707⟩
ChemBioChem, 2011, 12, pp.1039-1042. ⟨10.1002/cbic.201000707⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d49ffd671cd000135c01084b0702a65
https://doi.org/10.1002/cbic.201000707

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Synthesis of (S)- and (R)-5-Oxo-piperazine-2-Carboxylic Acid and Its Application to Peptidomimetics

Autor: Stefano Carboni, Karine Guitot, Oliver Reiser, Umberto Piarulli

Publikováno v: The Journal of Organic Chemistry. 74:8433-8436

A straightforward synthesis of (S)- and (R)-N-Boc-5-oxo-piperazine-2-carboxylic acid is reported starting from L- or D-serine and ethyl glyoxylate. Those were evaluated as constituents in two tetrapeptides by studying their secondary structure by (1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77a23ddd94c797c03e714351cfa3d1a
https://doi.org/10.1021/jo901389q

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