Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Karine, Alvarez"'
Autor:
Mikael Feracci, Sergio Hernandez, Laura Garlatti, Clemence Mondielli, Renaud Vincentelli, Bruno Canard, Juan Reguera, François Ferron, Karine Alvarez
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 374-383 (2024)
The large Bunyavirales order includes several families of viruses with a segmented ambisense (−) RNA genome and a cytoplasmic life cycle that starts by synthesizing viral mRNA. The initiation of transcription, which is common to all members, relies
Externí odkaz:
https://doaj.org/article/b2e119ae568140c0b04a06af9f5b24e9
Autor:
Aurélie Chazot, Claire Zimberger, Mikael Feracci, Adel Moussa, Steven Good, Jean-Pierre Sommadossi, Karine Alvarez, François Ferron, Bruno Canard
Publikováno v:
PLoS Biology, Vol 22, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/1f28c80a6c2249f99b5ce2dcf371e76b
Autor:
Thi Hong Van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, François Ferron
Publikováno v:
IUCrJ, Vol 9, Iss 4, Pp 468-479 (2022)
Arenaviruses are emerging enveloped negative-sense RNA viruses that cause neurological and hemorrhagic diseases in humans. Currently, no FDA-approved vaccine or therapeutic agent is available except for ribavirin, which must be administered early dur
Externí odkaz:
https://doaj.org/article/543ece24101048e586ac6487841a0ba8
Autor:
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S. Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an
Externí odkaz:
https://doaj.org/article/10c0996a692f427a8bc1883d8ce5e61e
Autor:
Nicolas Papageorgiou, Afroditi Vaitsopoulou, Awa Diop, Thi Hong Van Nguyen, Bruno Canard, Karine Alvarez, François Ferron
Publikováno v:
FEBS Open Bio, Vol 11, Iss 4, Pp 1076-1083 (2021)
Arenaviruses are enveloped viruses containing a segmented, negative, and ambisense single‐stranded RNA genome wrapped with a nucleoprotein (NP). The NP is the most abundant viral protein in infected cells and plays a critical role in both replicati
Externí odkaz:
https://doaj.org/article/8b45f5e0e5d34624806bf99f096fa6df
Autor:
Magali Saez-Ayala, Elsie Laban Yekwa, Mauro Carcelli, Bruno Canard, Karine Alvarez, François Ferron
Publikováno v:
IUCrJ, Vol 5, Iss 2, Pp 223-235 (2018)
The Arenaviridae family, together with the Bunyaviridae and Orthomyxoviridae families, is one of the three negative-stranded RNA viral families that encode an endonuclease in their genome. The endonuclease domain is at the N-terminus of the L protein
Externí odkaz:
https://doaj.org/article/441ade17680f410fa3b418e13e4610de
Autor:
Nicolas Papageorgiou, Maria Spiliopoulou, Thi-Hong Van Nguyen, Afroditi Vaitsopoulou, Elsie Yekwa Laban, Karine Alvarez, Irene Margiolaki, Bruno Canard, François Ferron
Publikováno v:
Viruses, Vol 12, Iss 7, p 772 (2020)
Arenaviridae is a family of viruses harbouring important emerging pathogens belonging to the Bunyavirales order. Like in other segmented negative strand RNA viruses, the nucleoprotein (NP) is a major actor of the viral life cycle being both (i) the n
Externí odkaz:
https://doaj.org/article/be3e1ee0e2b44ddc80f928f3c1892973
Autor:
Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Five to ten million individuals are infected by Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 is transmitted through prolonged breast-feeding, by sexual contacts and by transmission of infected T lymphocytes through blood transfusion. One to te
Externí odkaz:
https://doaj.org/article/6947e6f22ac54819bbe91b415300d1aa
Autor:
Sergio Hernández, Mikael Feracci, Carolina Trajano De Jesus, Priscila El Kazzi, Rafik Kaci, Laura Garlatti, Clemence Mondielli, Fabrice Bailly, Philippe Cotelle, Franck Touret, Xavier de Lamballerie, Bruno Coutard, Etienne Decroly, Bruno Canard, François Ferron, Karine Alvarez
Publikováno v:
Antiviral Research
Antiviral Research, 2022, 204, pp.105364. ⟨10.1016/j.antiviral.2022.105364⟩
Antiviral Research, 2022, 204, pp.105364. ⟨10.1016/j.antiviral.2022.105364⟩
International audience; Viral exoribonucleases are uncommon in the world of RNA viruses. To date, they have only been identified in the Arenaviridae and the Coronaviridae families. The exoribonucleases of these viruses play a crucial role in the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa25de2e57d37a3e1fc6b99f9cc793c4
https://hal.science/hal-03860671
https://hal.science/hal-03860671
Autor:
Mikael Feracci, Cécilia Eydoux, Véronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Françoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurélie Chazot, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, François Ferron, Bruno Canard
Publikováno v:
Antiviral Research
Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩
Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩
International audience; AT-752 is a guanosine analogue prodrug active against dengue virus (DENV). In infected cells, it is metabolized into 2 '-methyl-2 '-fluoro guanosine 5 '-triphosphate (AT-9010) which inhibits RNA synthesis in acting as a RNA ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e83f8c477b054811808f29f63f4776
https://doi.org/10.1016/j.antiviral.2023.105574
https://doi.org/10.1016/j.antiviral.2023.105574