Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Karina Silina"'
Autor:
Mart van Rijthoven, Simon Obahor, Fabio Pagliarulo, Maries van den Broek, Peter Schraml, Holger Moch, Jeroen van der Laak, Francesco Ciompi, Karina Silina
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024)
Abstract Background Tertiary lymphoid structures (TLSs) are dense accumulations of lymphocytes in inflamed peripheral tissues, including cancer, and are associated with improved survival and response to immunotherapy in various solid tumors. Histolog
Externí odkaz:
https://doaj.org/article/0ae3f5aeefc243b794418080e7ea09ca
Autor:
Paulino Tallón de Lara, Héctor Castañón, Marijne Vermeer, Nicolás Núñez, Karina Silina, Bettina Sobottka, Joaquín Urdinez, Virginia Cecconi, Hideo Yagita, Farkhondeh Movahedian Attar, Stefanie Hiltbrunner, Isabelle Glarner, Holger Moch, Sònia Tugues, Burkhard Becher, Maries van den Broek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in b
Externí odkaz:
https://doaj.org/article/d4c93583ff8e4ff4b53a6a528ca96962
Autor:
Fabio Pagliarulo, Phil F. Cheng, Laurin Brugger, Nick van Dijk, Michiel van den Heijden, Mitchell P. Levesque, Karina Silina, Maries van den Broek
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations. Here, we explored molecular,
Externí odkaz:
https://doaj.org/article/9c2f6ede25f44253b1958c5ec11152c9
Autor:
Nick van Dijk, Alberto Gil-Jimenez, Karina Silina, Maurits L. van Montfoort, Sarah Einerhand, Lars Jonkman, Charlotte S. Voskuilen, Dennis Peters, Joyce Sanders, Yoni Lubeck, Annegien Broeks, Erik Hooijberg, Daniel J. Vis, Maries van den Broek, Lodewyk F. A. Wessels, Bas W. G. van Rhijn, Michiel S. van der Heijden
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power. A comprehensive overview of the tumor immune contexture, including Terti
Externí odkaz:
https://doaj.org/article/8fafb947107347b58fd43347731cd2e1
Autor:
Linda Schadt, Colin Sparano, Nicole Angelika Schweiger, Karina Silina, Virginia Cecconi, Giulia Lucchiari, Hideo Yagita, Emilien Guggisberg, Sascha Saba, Zuzana Nascakova, Winfried Barchet, Maries van den Broek
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1236-1248.e7 (2019)
Summary: Sensing of cytoplasmic DNA by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) results in production of the dinucleotide cGAMP and consecutive activation of stimulator of interferon genes (STING) followed by pro
Externí odkaz:
https://doaj.org/article/2553b6df9d3e425e9bcfd1527c3603bd
Autor:
Karina Silina, David Kroeger
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/f3755cd59b9f4c34b2286d28602f12ab
Autor:
Soizic Garaud, Pawel Zayakin, Laurence Buisseret, Undine Rulle, Karina Silina, Alexandre de Wind, Gert Van den Eyden, Denis Larsimont, Karen Willard-Gallo, Aija Linē
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
An important role for tumor infiltrating B lymphocytes (TIL-B) in the immune response to cancer is emerging; however, very little is known about the antigen specificity of antibodies produced in situ. The presence of IgA antibodies in the tumor micro
Externí odkaz:
https://doaj.org/article/3eac83e6fde64c8eaab9b0557dac1c27
Autor:
Florian Posch, Karina Silina, Sebastian Leibl, Axel Mündlein, Holger Moch, Alexander Siebenhüner, Panagiotis Samaras, Jakob Riedl, Michael Stotz, Joanna Szkandera, Herbert Stöger, Martin Pichler, Roger Stupp, Maries van den Broek, Peter Schraml, Armin Gerger, Ulf Petrausch, Thomas Winder
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Tertiary lymphoid structures (TLS) are associated with favorable outcome in non-metastatic colorectal carcinoma (nmCRC), but the dynamics of TLS maturation and its association with effective anti-tumor immune surveillance in nmCRC are unclear. Here,
Externí odkaz:
https://doaj.org/article/b7a42bdf173b4855b20cfe83ca4088e4
Autor:
Srividya Sundararaman, Alexey Y. Karulin, Tameem Ansari, Nadine BenHamouda, Judith Gottwein, Sreenivas Laxmanan, Steven M. Levine, John T. Loffredo, Stephanie McArdle, Christine Neudoerfl, Diana Roen, Karina Silina, Mackenzie Welch, Paul V. Lehmann
Publikováno v:
Cells, Vol 4, Iss 1, Pp 21-39 (2015)
The primary goal of immune monitoring with ELISPOT is to measure the number of T cells, specific for any antigen, accurately and reproducibly between different laboratories. In ELISPOT assays, antigen-specific T cells secrete cytokines, forming spots
Externí odkaz:
https://doaj.org/article/4b8b577842b84291b39e2adf1401c336
Autor:
Karina Silina
Publikováno v:
Cancer Cell, 41 (5)
Cytotoxic T cells are indispensable for the body's fight against most cancers. In the current issue of Cancer Cell, Gaglia et al. reveal how changes in the tumor tissue architecture creating niches of T cell-B cell interac-tions may support anti-tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a19b9a0359f1782d86cc951640da59a
https://hdl.handle.net/20.500.11850/617141
https://hdl.handle.net/20.500.11850/617141