Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Karina S. Machado"'
Autor:
Elton José Ferreira Chaves, Adriano Velasque Werhli, Gerd B. Rocha, Carlos H. da Silveira, Alex Camargo, Marcus Tullius Scotti, Rafaela Salgado Ferreira, Karina S. Machado, Igor Barden Grillo, Rafael E. O. Rocha, Fabiana Costa Guedes, Leonardo Henrique França de Lima, Luiz Eduardo Gomes da Cruz, Pedro H. C. Fischer, Leon Sulfierry Corrêa Costa
Publikováno v:
Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The main-protease (Mpro) catalyzes a crucial step for the SARS-CoV-2 life cycle. The recent SARS-CoV-2 presents the main protease (MCoV2pro) with 12 mutations compared to SARS-CoV (MCoV1pro). Recent studies point out that these subtle differences lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7854d9bb4677ffe89fa8369fcd27689b
https://doi.org/10.1080/07391102.2021.1924271
https://doi.org/10.1080/07391102.2021.1924271
Autor:
Mayara Sandrielly Pereira Soares, Wilson Cunico, Daniel Schuch da Silva, Cristina W. Nogueira, João Luis Rheingantz Scaini, Franciele Martini, Bruna da Silveira de Mattos, Anita Avila de Souza, Cesar Emiliano Hoffman da Silva, Karina S. Machado, Ana Paula Pesarico, Roselia Maria Spanevello
Publikováno v:
Neurochemical Research. 45:241-253
This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837365a75938d7186f80213b1a6ef6d6
https://doi.org/10.1007/s11064-019-02929-8
https://doi.org/10.1007/s11064-019-02929-8
Autor:
Yasmin Castillos de Ibrahim das Neves, Ana Rita Gomes, Ana Júlia Reis, Arnab Pain, João Luis Rheingantz Scaini, Adriano Velasque Werhli, Daniela Fernandes Ramos, Jody Phelan, João Perdigão, Susana Campino, Maria Lucia Rosa Rossetti, Karina S. Machado, Pedro Eduardo Almeida da Silva, Taane G. Clark, Isabel Portugal, Elis R. Dalla-Costa, Jaciara Diniz, Andrea von Groll, Gisela Unis, Priscila Cristina Bartolomeu Halicki, Miguel Viveiros, Júlia Silveira Vianna
Publikováno v:
Tuberculosis (Edinburgh, Scotland). 131
Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714c58e45ec28ec9d2c1072cb269f25e
https://pubmed.ncbi.nlm.nih.gov/34673379
https://pubmed.ncbi.nlm.nih.gov/34673379
Autor:
Eduardo Kenji Hasegawa de Freitas, Adriano Velasque Werhli, Karina S. Machado, Maurício Balboni, Alex Camargo
Publikováno v:
Intelligent Systems ISBN: 9783030916985
Intelligent Systems
Intelligent Systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::695c106d345545701f59341e4dbcfa27
https://doi.org/10.1007/978-3-030-91699-2_6
https://doi.org/10.1007/978-3-030-91699-2_6
Autor:
Julia Quarti Cardoso, Raphael Silveira Vidal, Estela Fernandes e Silva, Deyse Cristina Madruga Carvalho, Luiz Henrique Agra Cavalcante-Silva, Alessandra Costa Lopes, Karina S. Machado, Ana Paula de Souza Votto, Sandra Rodrigues-Mascarenhas, Vivian M. Rumjanek, Mariana Teixeira Santos Figueiredo Salgado
Publikováno v:
Prostaglandinsother lipid mediators. 155
This study aimed to characterize the relationship between the COX2 and ALOX5 genes, as well as their link with the multidrug resistance (MDR) phenotype in sensitive (K562) and MDR (K562-Lucena and FEPS) erythroleukemia cells. For this, the inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0411ebe8618058bdb95eee8089d0c6
https://pubmed.ncbi.nlm.nih.gov/33975019
https://pubmed.ncbi.nlm.nih.gov/33975019
Autor:
Mateus Madail Santin, Karina S. Machado, Cristiane Rios Petrarca, Samuel C. Dumith, Timóteo Matthies Rico, Samanta Winck Madruga, Vanessa Pellegrini Fernandes
Publikováno v:
Journal of Medical Systems
Cancer patients are often not sufficiently oriented to manage side effects at home. Sending text messages with self-care guidelines aimed managing side effects is the main objective of this randomized controlled trial. Patients who started outpatient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ba5f3a280afbb322bc4a166da951c8
https://doi.org/10.1007/s10916-020-01663-x
https://doi.org/10.1007/s10916-020-01663-x
Autor:
Eder J. Lenardão, Magdalena Obieziurska-Fabisiak, Karina S. Machado, Vanessa Nascimento, Juan Kong, Anna Kula-Pacurar, Agnieszka Dąbrowska, Claudio Santi, Ying Lei, Cecilia Scimmi, Luca Sancineto, Krzysztof Pyrc, Jacek Ścianowski, Haitao Yang, Gianluca Ciancaleoni, Francesca Mangiavacchi, Adriano Velasque Werhli, Yao Zhao, Agata J. Pacuła
New Ebselen-like derivatives resulted to be very strong in vitro inhibitors of SARS-CoV-2 main protease. We demonstrated that this activity mainly depends on the electrophilicity of the selenium atom that is considerably higher in the N-substituted 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a3e7f6d68b6f72f77bf0c2097475b1
https://doi.org/10.26434/chemrxiv.12994250
https://doi.org/10.26434/chemrxiv.12994250
Autor:
Ana Laura Venquiaruti Escarrone, Marta Marques Souza, Nicole Soares Guidony, João Luis Rheingantz Scaini, Matheus William Bandeira de Oliveira, Claudio L.Q. Bastos, Karina S. Machado
Publikováno v:
Environmental pollution (Barking, Essex : 1987). 271
Chemicals such as triclosan are a concern because of their presence on daily products (soap, deodorant, hand sanitizers …), consequently this compound has an ubiquitous presence in the environment. Little is known about the effect of this bacterici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b72443caa799a98f5785968ccbe533a
https://pubmed.ncbi.nlm.nih.gov/33383428
https://pubmed.ncbi.nlm.nih.gov/33383428
Autor:
Karina S. Machado, Marcelo Gonçalves Montes D'Oca, Matheus William Bandeira de Oliveira, João Luis Rheingantz Scaini, Diego da Costa Cabrera, Luiz Eduardo Maia Nery, Adriano Velasque Werhli, Eduarda Santa-Helena, Carla Amorim Neves Gonçalves
Publikováno v:
Life sciences. 259
Aims From the synthesis of 43 lipophilic dihydropyridines, the aim of this study was to verify whether the new dihydropyridines have calcium channel affinity using coupling studies and to determine antihypertensive and antioxidant properties, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024b96d86c6814c7f3b4a24f3bd65000
https://pubmed.ncbi.nlm.nih.gov/32763289
https://pubmed.ncbi.nlm.nih.gov/32763289
Publikováno v:
Expert Systems with Applications. 171:114558
Modern systems make use of virtualization to build scalable and elastic applications. A major example is cloud computing, which has emerged in the last decades as a cost-effective paradigm for hosting and delivering services over the Internet. Cloud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bab7ccec43ee2c340ce9aab928b70da
https://doi.org/10.1016/j.eswa.2020.114558
https://doi.org/10.1016/j.eswa.2020.114558