Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karina R, Vaida"'
Autor:
Jessica Able, Benjamin C. Milgram, Loren Berry, Melanie Cooke, Liyue Huang, John Butler, Hongbing Huang, Violeta Yu, Kristin Taborn, John D. Roberts, Steven Altmann, Margaret Y. Chu-Moyer, John Yeoman, Jean Wang, Roman Shimanovich, Russell Graceffa, Matthew Weiss, Thomas Kornecook, Christopher P Ilch, Bryan D. Moyer, Christiane Boezio, Isaac E. Marx, Brian A. Sparling, Emily A. Peterson, Gwen Rescourio, Charles Kreiman, Elma Feric Bojic, Karina R. Vaida, Angel Guzman-Perez, Dawn Zhu, Hua Gao, Laurie B. Schenkel, Michael Jarosh, Hanh Nho Nguyen, Joseph Ligutti, Alessandro Boezio, Hakan Gunaydin, Daniel S. La, Thomas Dineen, Robert T. Fremeau, Robert S. Foti, Min-Hwa Jasmine Lin, Erin F. DiMauro, John Stellwagen
Publikováno v:
Journal of Medicinal Chemistry. 60:5990-6017
Because of its strong genetic validation, NaV1.7 has attracted significant interest as a target for the treatment of pain. We have previously reported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors that demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6062704d531ce83c1a6122ecc44600
https://doi.org/10.1021/acs.jmedchem.6b01850
https://doi.org/10.1021/acs.jmedchem.6b01850
Autor:
Zihao Hua, Michele Potashman, Carol Babij, Manory Fernando, Nobuko Nishimura, Josette Carnahan, Joseph L. Kim, Linda F. Epstein, Matthew R. Lee, Kevin Yang, Richard T. Lewis, Douglas A. Whittington, Longbin Liu, Karina R. Vaida, Howard Bregman, Shuyan Yi, Mark H. Norman, Matthew W. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2215-2234
One of the challenges for targeting B-Raf(V600E) with small molecule inhibitors had been achieving adequate selectivity over the wild-type protein B-Raf(WT), as inhibition of the latter has been associated with hyperplasia in normal tissues. Recent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827984e880dbf904a5d196e7229c4921
https://doi.org/10.1016/j.bmc.2016.03.055
https://doi.org/10.1016/j.bmc.2016.03.055
Autor:
Karen Rex, Douglas A. Whittington, David Bauer, Steven F. Bellon, Jean-Christophe Harmange, Martin A. Broome, Alessandro Boezio, Christiane Boezio, Karina R. Vaida, Deborah Choquette, Isabelle Dussault, Katrina W. Copeland, Emily A. Peterson, Yohannes Teffera, Roman Shimanovich, Brian K. Albrecht, Richard T. Lewis, Michele Potashman, Jingzhou Liu, Julia Lohman, Angela Coxon, Min-Hwa Jasmine Lin, Satoko Hirai
Publikováno v:
Journal of Medicinal Chemistry. 59:2328-2342
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16401f5e9358f2456fce2725cd044c7
https://doi.org/10.1021/acs.jmedchem.5b01716
https://doi.org/10.1021/acs.jmedchem.5b01716
Autor:
Holly L. Deak, Richard Kendall, Chaves Mary, Robert Radinsky, Grace Chung, Annette Bak, Yang Dai, Bingfan Du, Karina R. Vaida, Min-Hwa Jasmine Lin, Hanh Nho Nguyen, Brian L. Hodous, Laurie B. Schenkel, Tammy L. Bush, Patrick Eden, Paul S. Andrews, Liyue Huang, Xuhai Be, Philip R. Olivieri, Stephanie D. Geuns-Meyer, Victor J. Cee, Kelly Hanestad, Marc Payton, Jin Tang, Vinod F. Patel, Pedro J. Beltran, Beth Ziegler
Publikováno v:
Journal of Medicinal Chemistry. 58:5189-5207
Efforts to improve upon the physical properties and metabolic stability of Aurora kinase inhibitor 14a revealed that potency against multidrug-resistant cell lines was compromised by increased polarity. Despite its high in vitro metabolic intrinsic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12730d02cfac93673e41d912f0563da7
https://doi.org/10.1021/acs.jmedchem.5b00183
https://doi.org/10.1021/acs.jmedchem.5b00183
Autor:
Russell F, Graceffa, Alessandro A, Boezio, Jessica, Able, Steven, Altmann, Loren M, Berry, Christiane, Boezio, John R, Butler, Margaret, Chu-Moyer, Melanie, Cooke, Erin F, DiMauro, Thomas A, Dineen, Elma, Feric Bojic, Robert S, Foti, Robert T, Fremeau, Angel, Guzman-Perez, Hua, Gao, Hakan, Gunaydin, Hongbing, Huang, Liyue, Huang, Christopher, Ilch, Michael, Jarosh, Thomas, Kornecook, Charles R, Kreiman, Daniel S, La, Joseph, Ligutti, Benjamin C, Milgram, Min-Hwa Jasmine, Lin, Isaac E, Marx, Hanh N, Nguyen, Emily A, Peterson, Gwen, Rescourio, John, Roberts, Laurie, Schenkel, Roman, Shimanovich, Brian A, Sparling, John, Stellwagen, Kristin, Taborn, Karina R, Vaida, Jean, Wang, John, Yeoman, Violeta, Yu, Dawn, Zhu, Bryan D, Moyer, Matthew M, Weiss
Publikováno v:
Journal of medicinal chemistry. 60(14)
Because of its strong genetic validation, Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8ea84d65ab7dd59414c7bfc36426140
https://pubmed.ncbi.nlm.nih.gov/28324649
https://pubmed.ncbi.nlm.nih.gov/28324649
Autor:
Alessandro A, Boezio, Katrina W, Copeland, Karen, Rex, Brian, K Albrecht, David, Bauer, Steven F, Bellon, Christiane, Boezio, Martin A, Broome, Deborah, Choquette, Angela, Coxon, Isabelle, Dussault, Satoko, Hirai, Richard, Lewis, Min-Hwa Jasmine, Lin, Julia, Lohman, Jingzhou, Liu, Emily A, Peterson, Michele, Potashman, Roman, Shimanovich, Yohannes, Teffera, Douglas A, Whittington, Karina R, Vaida, Jean-Christophe, Harmange
Publikováno v:
Journal of medicinal chemistry. 59(6)
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d316417441481eaad06208d8a5d80b98
https://pubmed.ncbi.nlm.nih.gov/26812066
https://pubmed.ncbi.nlm.nih.gov/26812066
Autor:
Christiane Boezio, Michele Potashman, Yohannes Teffera, Brian K. Albrecht, Julia Lohman, Karina R. Vaida, Alessandro Boezio, Emily A. Peterson, Steven F. Bellon, Deborah Choquette, David Bauer, Katrina W. Copeland, Isabelle Dussault, Roman Shimanovich, Min-Hwa Jasmine Lin, Martin A. Broome, Richard T. Lewis, Jean-Christophe Harmange, Karen Rex, Douglas A. Whittington, Jingzhou Liu
Publikováno v:
Journal of medicinal chemistry. 58(5)
The overexpression of c-Met and/or hepatocyte growth factor (HGF), the amplification of the MET gene, and mutations in the c-Met kinase domain can activate signaling pathways that contribute to cancer progression by enabling tumor cell proliferation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8df9c5e2d13e9c214982a8d6426b0c7
https://pubmed.ncbi.nlm.nih.gov/25901648
https://pubmed.ncbi.nlm.nih.gov/25901648
Autor:
Zihao Hua, Mark H. Norman, Nobuko Nishimura, Manory Fernando, Matthew W. Martin, Matthew R. Lee, Carol Babij, Joseph L. Kim, Kevin Yang, Karina R. Vaida, Longbin Liu, Michele Potashman, Richard T. Lewis, Linda F. Epstein, Douglas A. Whittington, Josette Carnahan, Howard Bregman, Shuyan Yi
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3093
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b2b7432ff8465ba0abd61f4c9b1541
https://doi.org/10.1016/j.bmc.2016.05.014
https://doi.org/10.1016/j.bmc.2016.05.014
Autor:
Karina R. Vaida, Martin A. Broome, Katrina W. Copeland, Douglas A. Whittington, Roman Shimanovich, David Bauer, Jean-Christophe Harmange, Karen Rex, Deborah Choquette, Christiane Boezio, Richard J. Lewis, Emily A. Peterson, Isabelle Dussault, Michele Potashman, Jingzhou Liu, Brian K. Albrecht, Alessandro Boezio, Julia Lohman, Yohannes Teffera, Steven F. Bellon, Min-Hwa Jasmine Lin
Publikováno v:
Journal of Medicinal Chemistry. 58:4087-4087
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645ba6c146fdac2c42f776575b0e6b4f
https://doi.org/10.1021/acs.jmedchem.5b00591
https://doi.org/10.1021/acs.jmedchem.5b00591
Autor:
Stephanie Geuns-Meyer, VictorJ. Cee, Holly L. Deak, Bingfan Du, Brian L. Hodous, Hanh Nho Nguyen, PhilipR. Olivieri, Laurie B. Schenkel, Karina R. Vaida, Paul Andrews, Annette Bak, Xuhai Be, Pedro J. Beltran, Tammy L. Bush, Mary K. Chaves, Grace Chung, Yang Dai, Patrick Eden, Kelly Hanestad, Liyue Huang
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 13, p5189-5207, 19p