Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Karina N. Dubé"'
Autor:
Joaquim Miguel Vieira, Sara Howard, Cristina Villa del Campo, Sveva Bollini, Karina N. Dubé, Megan Masters, Damien N. Barnette, Mala Rohling, Xin Sun, Laura E. Hankins, Daria Gavriouchkina, Ruth Williams, Daniel Metzger, Pierre Chambon, Tatjana Sauka-Spengler, Benjamin Davies, Paul R. Riley
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Priming of the adult mouse heart with Tβ4 activates dormant epicardium-derived cells to aid repair of injured myocardium. Here, Vieiraet al. explain this process and show that Tβ4 binds a chromatin remodeller BRG1 and activates Wt1, the key regulat
Externí odkaz:
https://doaj.org/article/016d532aec994a92bc77e854190df861
Autor:
Sonali Munshaw, Giles Neal, Karina N. Dubé, Susann Bruche, Jyoti Patel, Nicola Smart, Rachel Davies, Regent Lee, Ashok Handa, Andia N. Redpath, Keith M. Channon
Background and Aims: Thymosin β4 (Tβ4), is a small peptide implicated in mural VSMC differentiation in developing embryo. A proportion of Tβ4KO embryos die with vascular haemorrhage and surviving adults display aortic VSMC and elastin defects. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3696e8f88303fea2ee5e7d65e414c039
https://ora.ox.ac.uk/objects/uuid:e3241180-db55-4a6c-9779-978f44591f92
https://ora.ox.ac.uk/objects/uuid:e3241180-db55-4a6c-9779-978f44591f92
Autor:
Keith M. Channon, Andia N. Redpath, Sonali Munshaw, Jyoti Patel, Ashok Handa, Regent Lee, Susann Bruche, Nicola Smart, Karina N. Dubé
Publikováno v:
Young Investigators Award.
Vascular stability and tone are maintained by contractile smooth muscle cells (VSMCs). Injury-induced growth factors stimulate a phenotypic switching of VSMCs, from their quiescent contractile state to a more active synthetic phenotype that prolifera
Autor:
Roman Fischer, Giles Neal, Svenja Hester, Alisha N Jones, Nicola Smart, Susann Bruche, Sonali Munshaw, Keith M. Channon, Jyoti Patel, Rachel Davies, Ashok Handa, Karina N. Dubé, Michael Sattler, Andia N. Redpath, Regent Lee
Publikováno v:
The Journal of Clinical Investigation
J. Clin. Invest. 131:e127884 (2021)
J. Clin. Invest. 131:e127884 (2021)
Vascular stability and tone are maintained by contractile smooth muscle cells (VSMCs). However, injury-induced growth factors stimulate a contractile-synthetic phenotypic modulation which increases susceptibility to abdominal aortic aneurysm (AAA). A
Autor:
Nicola Smart, Karina N. Dubé
Publikováno v:
Expert opinion on biological therapy. 18(sup1)
Introduction: Formation of the vasculature is a complex process, defects in which can lead to embryonic lethality or disease in later life. Understanding mechanisms of vasculogenesis may facilitate the treatment of developmental defects and may be ex
Autor:
Mala Rohling, Paul R. Riley, Carolyn A. Carr, Joaquim M. Vieira, Karina N. Dubé, Linda Klotz, Sophie Norman, Megan Masters, Fumio Matsuzaki, Sveva Bollini
Publikováno v:
Nature
The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis, immune surveillance and lipid absorption from the gut. Recent evidence has proposed an entirely venous-derived mammalian lymphatic system. By contrast, here we s
Autor:
Sonali Munshaw, Karina N. Dubé, Nicola Smart, Jyoti Patel, Keith M. Channon, Andia N. Redpath, Susann Bruche
Publikováno v:
Cardiovascular Research. 114:S1-S2
Autor:
William T. Pu, Bin Zhou, Joaquim M. Vieira, Derek M. Yellon, Sveva Bollini, Anthony N. Price, Nicola Smart, Johannes Riegler, Paul R. Riley, Mark F. Lythgoe, Sean M. Davidson, Karina N. Dubé
Publikováno v:
Annals of the New York Academy of Sciences. 1269:92-101
Efficient cardiac regeneration postinfarction (MI) requires the replacement of lost cardiomyocytes, formation of new coronary vessels and appropriate modulation of the inflammatory response. However, insight into how to stimulate repair of the human
Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice
Autor:
Nicola, Smart, Johannes, Riegler, Cameron W, Turtle, Craig A, Lygate, Debra J, McAndrew, Katja, Gehmlich, Karina N, Dubé, Anthony N, Price, Vivek, Muthurangu, Andrew M, Taylor, Mark F, Lythgoe, Charles, Redwood, Paul R, Riley
Publikováno v:
Journal of Molecular and Cellular Cardiology
Sarcomere assembly is a highly orchestrated and dynamic process which adapts, during perinatal development, to accommodate growth of the heart. Sarcomeric components, including titin, undergo an isoform transition to adjust ventricular filling. Many
Autor:
Bin Zhou, William T. Pu, Derek M. Yellon, Joaquim M. Vieira, Karina N. Dubé, Johannes Riegler, Nicola Smart, Anthony N. Price, Sean M. Davidson, Mark F. Lythgoe, Paul R. Riley, Sveva Bollini
A significant bottleneck in cardiovascular regenerative medicine is the identification of a viable source of stem/progenitor cells that could contribute new muscle after ischaemic heart disease and acute myocardial infarction. A therapeutic ideal--re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6885877cb10d2ecf6e9bb5204373e2
https://ora.ox.ac.uk/objects/uuid:af41da49-c0db-4fd4-b14b-9b15708645cf
https://ora.ox.ac.uk/objects/uuid:af41da49-c0db-4fd4-b14b-9b15708645cf