Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Karina McDade"'
Autor:
Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
Externí odkaz:
https://doaj.org/article/3684566e972d48bda37be69378c00e42
Autor:
Colin Smith, Rustam Al-Shahi Salman, Karina McDade, Edward Christopher, Neshika Samarasekera, James J M Loan, Jamie Rose, Jack Barrington, Jeremy Hughes
Publikováno v:
BMJ Neurology Open, Vol 4, Iss 1 (2022)
Aims Pharmacological activation of the antioxidative transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) improves outcomes in experimental models of intracerebral haemorrhage (ICH). However, the Nrf2 pathway has not been previousl
Externí odkaz:
https://doaj.org/article/3cfe53a053a74e8583f76664a1754f3e
Autor:
Samantha K. Barton, Jenna M. Gregory, Bhuvaneish T. Selvaraj, Karina McDade, Christopher M. Henstridge, Tara L. Spires-Jones, Owen G. James, Arpan R. Mehta, David Story, Karen Burr, Dario Magnani, Adrian M. Isaacs, Colin Smith, Siddharthan Chandran
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but
Externí odkaz:
https://doaj.org/article/b45e0692110c4e06a184d5b851be4204
Autor:
Jenna M. Gregory, Daniel R. Whiten, Rebecca A. Brown, Teresa P. Barros, Janet R. Kumita, Justin J. Yerbury, Sandeep Satapathy, Karina McDade, Colin Smith, Leila M. Luheshi, Christopher M. Dobson, Mark R. Wilson
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-16 (2017)
Abstract It is now widely accepted in the field that the normally secreted chaperone clusterin is redirected to the cytosol during endoplasmic reticulum (ER) stress, although the physiological function(s) of this physical relocation remain unknown. W
Externí odkaz:
https://doaj.org/article/21bc7900713e4ebdb657794a389341be
Autor:
Poulomi Banerjee, Arpan R. Mehta, Raja S. Nirujogi, James Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R. Alessi, Bhuvaneish T. Selvaraj, Josef Priller, Siddharthan Chandran
Publikováno v:
Science advances 9(16), eabq0651 (2023). doi:10.1126/sciadv.abq0651
Banerjee, P, Mehta, A, Nirujogi, R S, Cooper, J, James, O G, Nanda, J, Longden, J, Burr, K, McDade, K, Salzinger, A, Paza, E, Newton, J, Story, D, Pal, S, Smith, C, Alessi, D R, Thangaraj Selvaraj, B, Priller, J & Chandran, S 2023, ' Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration ', Science Advances . https://doi.org/10.1126/sciadv.abq0651
Banerjee, P, Mehta, A, Nirujogi, R S, Cooper, J, James, O G, Nanda, J, Longden, J, Burr, K, McDade, K, Salzinger, A, Paza, E, Newton, J, Story, D, Pal, S, Smith, C, Alessi, D R, Thangaraj Selvaraj, B, Priller, J & Chandran, S 2023, ' Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration ', Science Advances . https://doi.org/10.1126/sciadv.abq0651
Although microglial activation is widely found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the underlying mechanism(s) are poorly understood. Here, using human-induced pluripotent stem cell–derived microglia-like cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffe9b8361917d07a830b67f50046784
https://pub.dzne.de/record/257688
https://pub.dzne.de/record/257688
Autor:
Alexander Haglund, Verena Zuber, Yifei Yang, Maya Abouzeid, Rahel Feleke, Jeong Hun Ko, Alexi Nott, Ann C. Babtie, James D. Mills, Louwai Muhammed, Liisi Laaniste, Djordje O. Gveric, Daniel Clode, Susanna Pagni, Ravishankara Bellampalli, Alyma Somani, Karina McDade, Jasper J. Anink, Lucia Mesarosova, Eleonora Aronica, Maria Thom, Sanjay M. Sisodiya, Prashant K. Srivastava, Dheeraj Malhotra, Julien Bryois, Leonardo Bottolo, Michael R. Johnson
Translating genome-wide association loci to therapies requires knowledge of the causal genes, their directionality of effect and the cell-types in which they act. To infer these relationships in the human brain, we implemented Mendelian randomisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1427c4abdeae3047a989d38ab0eea78
https://doi.org/10.1101/2022.11.28.517913
https://doi.org/10.1101/2022.11.28.517913
Autor:
Arpan R. Mehta, Karina McDade, Judith Newton, Marc-David Ruepp, Suvankar Pal, Siddharthan Chandran, Colin Smith, Bhuvaneish T. Selvaraj
A striking feature of sporadic amyotrophic lateral sclerosis (ALS) is the marked heterogeneity in disease duration; despite the stark median survival of three years from symptom onset, 10-20% of people with ALS survive longer than 10 years. An improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ad522b3f14ff2056cb398e353fff09
https://doi.org/10.1101/2022.09.01.22279305
https://doi.org/10.1101/2022.09.01.22279305
Autor:
Olivia M Rifai, James Longden, Judi O'Shaughnessy, Michael DE Sewell, Judith Pate, Karina McDade, Michael JD Daniels, Sharon Abrahams, Siddharthan Chandran, Barry W McColl, Christopher R Sibley, Jenna M Gregory
Publikováno v:
Rifai, O M, Longden, J, O'Shaughnessy, J, Sewell, M D E, Pate, J, McDade, K, Daniels, M J D, Abrahams, S, Chandran, S, McColl, B W, Sibley, C R & Gregory, J M 2022, ' Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72-ALS ', The Journal of Pathology, vol. 258, no. 4, pp. 366-381 . https://doi.org/10.1002/path.6008
Clinical heterogeneity observed across patients with amyotrophic lateral sclerosis (ALS) is a known complicating factor in identifying potential therapeutics, even within cohorts with the same mutation, such as C9orf72 hexanucleotide repeat expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d55e3013108500a0c42857e686b4ad4
https://pubmed.ncbi.nlm.nih.gov/36070099
https://pubmed.ncbi.nlm.nih.gov/36070099
Autor:
David Story, Karen Burr, Roderick N. Carter, Arpan R Mehta, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Colin Smith, Jenna M. Gregory, Giles E. Hardingham, Nicholas M. Morton, Don J. Mahad, Owen Dando, Karina McDade, Jyoti Nanda
Publikováno v:
Mehta, A R, Gregory, J M, Dando, O, Carter, R N, Burr, K, Nanda, J, Story, D, Mcdade, K, Smith, C, Morton, N M, Mahad, D J, Hardingham, G E, Chandran, S & Selvaraj, B T 2021, ' Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis ', Acta Neuropathologica . https://doi.org/10.1007/s00401-020-02252-5
Acta Neuropathologica
Acta Neuropathologica
Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbc73ad975fbf9d387a95cbaa104da6
https://doi.org/10.1007/s00401-020-02252-5
https://doi.org/10.1007/s00401-020-02252-5
Autor:
Timothy J. Aitman, Siddharthan Chandran, S. Marion de Proce, Karina McDade, Jenna M. Gregory, Colin Smith, I. Croy, Matthew R. Livesey
Publikováno v:
Gregory, J M, McDade, K, Livesey, M R, Croy, I, Marion de Proce, S, Aitman, T, Chandran, S & Smith, C 2020, ' Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis ', Neuropathology and Applied Neurobiology, vol. 46, no. 5, pp. 441-457 . https://doi.org/10.1111/nan.12597
Aims: The mechanisms underlying the selective degeneration of motor neurones in amyotrophic lateral sclerosis (ALS) are poorly understood. The aim of this study was to implement spatially resolved RNA sequencing in human post mortem cortical tissue f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adb72db43045a3010b9d6a4e6c07f9e
https://doi.org/10.1111/nan.12597
https://doi.org/10.1111/nan.12597