Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Karina M O'Connor"'
Autor:
Issam M Mayyas, Robert J Weeks, Robert C Day, Helena E Magrath, Karina M O’Connor, Olga Kardailsky, Timothy A Hore, Mark B Hampton, Ian M Morison
Publikováno v:
Epigenetics, Vol 16, Iss 11, Pp 1251-1259 (2021)
Although the mechanism of DNA demethylating drugs has been understood for many years, the direct effect of these drugs on methylation of the complementary strands of DNA has not been formally demonstrated. By using hairpin-bisulphite sequencing, we d
Externí odkaz:
https://doaj.org/article/1c6526df08f64f94b446cbb0b8761e4c
Publikováno v:
Free Radical Biology and Medicine. 170:131-149
Excessive production of microbicidal oxidants by neutrophils can damage host tissue. The short-term response of cells to oxidative stress is well understood, but the mechanisms behind long-term consequences require further clarification. Epigenetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08b1340d4bc7b21c34f61ce30386714
https://doi.org/10.1016/j.freeradbiomed.2020.12.453
https://doi.org/10.1016/j.freeradbiomed.2020.12.453
Publikováno v:
J Biol Chem
Excessive generation of oxidants by immune cells results in acute tissue damage. One mechanism by which oxidant exposure could have long-term effects is modulation of epigenetic pathways. We hypothesized that methylation of newly synthesized DNA in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee61b3ceef6b64d82221dcef7cd5ba37
https://doi.org/10.1074/jbc.ra120.013092
https://doi.org/10.1074/jbc.ra120.013092
Autor:
Ian M. Morison, Olga Kardailsky, Issam M Mayyas, Karina M. O'Connor, Robert C. Day, Timothy A. Hore, Mark B. Hampton, Helena E Magrath, Robert J. Weeks
Publikováno v:
Epigenetics
Although the mechanism of DNA demethylating drugs has been understood for many years, the direct effect of these drugs on methylation of the complementary strands of DNA has not been formally demonstrated. By using hairpin-bisulphite sequencing, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b6ca972e717031d80743d94b22e748
https://pubmed.ncbi.nlm.nih.gov/33315501
https://pubmed.ncbi.nlm.nih.gov/33315501
Autor:
Mark B. Hampton, Karina M. O'Connor
Publikováno v:
Molecules and Cells
Cell death pathways such as apoptosis can be activated in response to oxidative stress, enabling the disposal of damaged cells. In contrast, controlled intracellular redox events are proposed to be a significant event during apoptosis signaling, rega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb89e3e579c847bb363c3a5b1fb43739
https://pubmed.ncbi.nlm.nih.gov/26810076
https://pubmed.ncbi.nlm.nih.gov/26810076
Publikováno v:
Free Radical Biology and Medicine. 108:S51
Epidemiological evidence indicates that increased consumption of isothiocyanates is associated with reduced incidence of cancer. One mechanism to explain this is the ability of isothiocyanates to trigger apoptosis, including in cells that overexpress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9697a107475f9bf2cfd7c0e7d6b26eed
https://doi.org/10.1016/j.freeradbiomed.2017.04.185
https://doi.org/10.1016/j.freeradbiomed.2017.04.185
Autor:
Sarah G. Heath, Shelby G. Gray, Emilie M. Hamzah, Karina M. O’Connor, Stephanie M. Bozonet, Alex D. Botha, Pierre de Cordovez, Nicholas J. Magon, Jennifer D. Naughton, Dylan L. W. Goldsmith, Abigail J. Schwartfeger, Margaret Sunde, Alexander K. Buell, Vanessa K. Morris, Christoph Göbl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The conversion of a soluble protein into polymeric amyloid structures is a process that is poorly understood. Here, we describe a fully redox-regulated amyloid system in which cysteine oxidation of the tumor suppressor protein p16INK4a leads
Externí odkaz:
https://doaj.org/article/a18c6cf4e12e4615868661575f7fe88c