Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Karina J. Yoon"'
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Market, Michael E. Erwin, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 47, Iss , Pp 102045- (2024)
Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults. Trametinib is a kinase inhibitor that targets MEK1/2 and has been
Externí odkaz:
https://doaj.org/article/0515712cdd0f4633a52a9cf06e81c2dc
Autor:
Patrick L. Garcia, Aubrey L. Miller, Ling Zeng, Robert C. A. M. van Waardenburg, Eddy S. Yang, Karina J. Yoon
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage. Based on these findings, we hypothesized that a BETi would augment DN
Externí odkaz:
https://doaj.org/article/12e8ae439ad14ecdb98cf3110f05bea0
Autor:
Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Joshua C. Anderson, Christopher D. Willey, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Despite increasing incidence, treatment for hepatoblastoma has not changed significantly over the past 20 years. Chemotherapeutic strategies continue to rely on cisplatin, as it remains the most active single agent against hepatoblastoma. Ho
Externí odkaz:
https://doaj.org/article/651d99d3286c48f987b6b07498bbc8c8
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Markert, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, David K. Crossman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101099- (2021)
Patient-derived xenografts provide significant advantages over long-term passage cell lines when investigating efficacy of treatments for solid tumors. Our laboratory encountered a high-grade, metastatic, neuroendocrine-like tumor from a pediatric pa
Externí odkaz:
https://doaj.org/article/ba8c4f5263934279a3ed4ec995b89d8c
Autor:
Laura L. Stafman, Adele P. Williams, Raoud Marayati, Jamie M. Aye, Hooper R. Markert, Evan F. Garner, Colin H. Quinn, Shoeb B. Lallani, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Patient-derived xenografts (PDXs) provide an opportunity to evaluate the effects of therapies in an environment that more closely resembles the human condition than that seen with long-term passage cell lines. In the current studies, we inve
Externí odkaz:
https://doaj.org/article/ae4c4e6cac14422ea46500505cb9f16e
Autor:
Aubrey L. Miller, Samuel C. Fehling, Patrick L. Garcia, Tracy L. Gamblin, Leona N. Council, Robert C.A.M. van Waardenburg, Eddy S. Yang, James E. Bradner, Karina J. Yoon
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 419-430 (2019)
Background: DNA repair deficiency accumulates DNA damage and sensitizes tumor cells to PARP inhibitors (PARPi). Based on our observation that the BET inhibitor JQ1 increases levels of DNA damage, we evaluated the efficacy of JQ1 + the PARPi olaparib
Externí odkaz:
https://doaj.org/article/06329e4890dc457f95f1890ebe29c231
Autor:
Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 200-208 (2019)
Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously demonstrated that Proviral Integration site for Moloney murine leukemia (PIM) kinases promote tumo
Externí odkaz:
https://doaj.org/article/50eba423670a4f4380c1edd4eb9fdaa0
Autor:
Raoud Marayati, Laura V. Bownes, Laura L. Stafman, Adele P. Williams, Colin H. Quinn, Venkatram Atigadda, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100893- (2021)
Retinoic acid (RA) therapy has been utilized as maintenance therapy for high-risk neuroblastoma, but over half of patients treated with RA relapse. Neuroblastoma stem cell-like cancer cells (SCLCCs) are a subpopulation of cells characterized by the e
Externí odkaz:
https://doaj.org/article/e246226acc30403d9cd1e402f31f9618
Autor:
Stuart L. Cramer, Aubrey L. Miller, Joseph G. Pressey, Tracy L. Gamblin, Elizabeth A. Beierle, Brian D. Kulbersh, Patrick L. Garcia, Leona N. Council, Rupa Radhakrishnan, Skyler V. Hendrix, David R. Kelly, Raymond G. Watts, Karina J. Yoon
Publikováno v:
Frontiers in Oncology, Vol 7 (2018)
Therapy for rhabdomyosarcoma (RMS) has generally been limited to combinations of conventional cytotoxic agents similar to regimens originally developed in the late 1960s. Recently, identification of molecular alterations through next-generation seque
Externí odkaz:
https://doaj.org/article/f97b024380f34fc3b43aee2722ded019
The Effects of Protein Phosphatase 2A Activation with Novel Tricyclic Sulfonamides on Hepatoblastoma
Autor:
Laura V. Bownes, Janet R. Julson, Colin H. Quinn, Sara Claire Hutchins, Michael H. Erwin, Hooper R. Markert, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Jamie Aye, Karina J. Yoon, Michael Ohlmeyer, Elizabeth A. Beierle
Publikováno v:
Journal of Pediatric Surgery. 58:1145-1154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8952e70c8ee313b90200b90a9f6ac5f5
https://doi.org/10.1016/j.jpedsurg.2023.02.017
https://doi.org/10.1016/j.jpedsurg.2023.02.017