Výsledky vyhledávání - "Karina Hansen Kjær"

Akademický článek

Autor: Alistair C Darby, Colin J McInnes, Karina Hansen Kjær, Ann R Wood, Margaret Hughes, Pia Møller Martensen, Alan D Radford, Neil Hall, Julian Chantrey

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e96439 (2014)

Squirrelpox virus (SQPV) shows little evidence for morbidity or mortality in North American grey squirrels (Sciurus carolinensis), in which the virus is endemic. However, more recently the virus has emerged to cause epidemics with high mortality in E

Externí odkaz: https://doaj.org/article/f6f5f35f8f284838a0b0f00aca1b8e61

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Enzymatically active 2′,5′-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage

Autor: Anne Kuusksalu, Mailis Päri, Annika Lopp, Merike Kelve, Just Justesen, Karina Hansen Kjær

Publikováno v: Biochimie. 97:200-209

2′,5′-Oligoadenylate synthetases (OASs) belong to the nucleotidyl transferase family together with poly(A) polymerases, CCA-adding enzymes and the recently discovered cyclic-GMP-AMP synthase (cGAS). Mammalian OASs have been thoroughly characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b036e770505510d2b1d5509ec45e14e8
https://doi.org/10.1016/j.biochi.2013.10.015

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Characterization of human phosphodiesterase 12 and identification of a novel 2′-5′ oligoadenylate nuclease – The ectonucleotide pyrophosphatase/phosphodiesterase 1

Autor: Kasper R. Andersen, Just Justesen, Karina Hansen Kjær, Jesper Buchhave Poulsen, Pia M. Martensen, Anna L. Vestergaard

Publikováno v: Biochimie. 94:1098-1107

The vertebrate 2-5A system is part of the innate immune response and central to cellular antiviral activities. Upon activation by viral double-stranded RNA, 5′-triphosphorylated, 2′-5′-linked oligoadenylate polyribonucleotides (2-5As) are synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532550b8810fd9d12a35ba057257e893
https://doi.org/10.1016/j.biochi.2012.01.012

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Enzyme assays for synthesis and degradation of 2-5As and other 2'-5' oligonucleotides

Autor: Just Justesen, Pia M. Martensen, Jesper Buchhave Poulsen, Karina Hansen Kjær

Publikováno v: BMC Biochemistry
Poulsen, J B, Kjær, K H, Justesen, J & Martensen, P M 2015, ' Enzyme assays for synthesis and degradation of 2-5As and other 2'-5' oligonucleotides ', B M C Biochemistry, vol. 16, no. 15, pp. 1-14 . https://doi.org/10.1186/s12858-015-0043-8

Background The 5′-triphosphorylated, 2′-5′-linked oligoadenylate polyribonucleotides (2-5As) are central to the interferon-induced antiviral 2-5A system. The 2-5As bind and activate the RNase L, an endoRNase degrading viral and cellular RNA lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ea9aaa0b025a2a5bec4a1ce91e991d
https://pubmed.ncbi.nlm.nih.gov/26113370

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Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha

Autor: Signe Skovbjerg, Karina Hansen Kjær, Charlotte Stentoft, Pia M. Martensen, Camilla Kronborg, Sarah Rohde, Mariann Fagernæs Hansen, Anders M. Kristensen, Trine R. Jensen, Eva Greibe

Publikováno v: Hansen, M F, Greibe, E, Thomsen, S S, Rohde, S, Kristensen, A C M, Jensen, T R, Nielsen, C S, Kjær, K H, Kronborg, C S & Martensen, P M 2015, ' Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha ', Cellular Signalling, vol. 27, no. 7, pp. 1356-1368 . https://doi.org/10.1016/j.cellsig.2015.03.020

The signal transducer and activator of transcription 3 (STAT3) is a well-described pro-oncogene found constitutively activated in several cancer types. Folates are B vitamins that, when taken up by cells through the Reduced Folate Carrier (RFC), are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d37a4dc28594ed29c508a170542aa97
https://pubmed.ncbi.nlm.nih.gov/25841994

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Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism

Autor: Jytte Pahus, Mariann Fagernæs Hansen, Jesper Buchhave Poulsen, Just Justesen, Karina Hansen Kjær, Erik Ilsø Christensen, Pia M. Martensen

Publikováno v: Kjær, K H, Pahus, J, Hansen, M F, Poulsen, J B, Christensen, E I, Justesen, J & Martensen, P M 2014, ' Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism ', B M C Cell Biology, vol. 15, no. 33, pp. 1-14 . https://doi.org/10.1186/1471-2121-15-33
BMC Cell Biology

BACKGROUND: The expression of 2'-5'-Oligoadenylate synthetases (OASs) is induced by type 1 Interferons (IFNs) in response to viral infection. The OAS proteins have a unique ability to produce 2'-5' Oligoadenylates, which bind and activate the ribonuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de222f280494622eef9cb6671b43e68a
https://doi.org/10.1186/1471-2121-15-33

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Autor: Ann R. Wood, Neil Hall, Alan D Radford, Alistair C. Darby, Pia M. Martensen, Colin McInnes, Julian Chantrey, Margaret Hughes, Karina Hansen Kjær

Publikováno v: PLoS ONE
Darby, A C, McInnes, C J, Kjær, K H, Wood, A R, Hughes, M, Martensen, P M, Radford, A D, Hall, N & Chantrey, J 2014, ' Novel host-related virulence factors are encoded by squirrelpox virus, the main causative agent of epidemic disease in red squirrels in the UK ', PLOS ONE, vol. 9, no. 7, e96439, pp. 1-7 . https://doi.org/10.1371/journal.pone.0096439
PLOS ONE
PLoS ONE, Vol 9, Iss 7, p e96439 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef96f8e50cfb36c8acec09ba8ec7c340

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Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

Autor: Nicholas J. Hoogenraad, Jesper Buchhave Poulsen, Just Justesen, Kasper R. Andersen, Pierre Faou, Gert H. Talbo, Karina Hansen Kjær, Pia M. Martensen, Fiona Durand, Anna L. Vestergaard, Ditlev E. Brodersen

Publikováno v: Nucleic Acids Research
Poulsen, J B, Andersen, K R, Kjær, K H, Durand, F, Faou, P, Vestergaard, A L, Talbo, G H, Hoogenraad, N, Brodersen, D E, Justesen, J & Martensen, P M 2011, ' Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover ', Nucleic Acids Research, vol. 39, no. 9, pp. 3754-70 . https://doi.org/10.1093/nar/gkq1282

The vertebrate 2-5A system is part of the innate immune system and central to cellular antiviral defense. Upon activation by viral double-stranded RNA, 5′-triphosphorylated, 2′–5′-linked oligoadenylate polyribonucleotides (2-5As) are synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339be1b12b27ecba228d65622c02d850
https://pubmed.ncbi.nlm.nih.gov/21245038

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Evolution of the 2′-5′-Oligoadenylate Synthetase Family in Eukaryotes and Bacteria

Autor: Karina Hansen Kjær, Tõnu Reintamm, Just Justesen, Merike Kelve, Pia Moeller Martensen, Jesper Buchhave Poulsen, Emilie Saby

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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13 páginas, 5 figuras, 3 tablas.
The 2 0 -5 0 -oligoadenylate synthetase (OAS) belongs to a nucleotidyl transferase family that includes poly(A) polymerases and CCA-adding enzymes. In mammals and birds, the OAS functions in the interferon syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6702fda4c8be59f487d4fe470d3c41
http://hdl.handle.net/10261/57436

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