Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karina García-Martínez"'
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155684 (2016)
Interleukin-2 (IL2) is a growth factor for several immune cells and its function depends on its binding to IL2Rs in the cell membrane. The most accepted model for the assembling of IL2-IL2R complexes in the cell membrane is the Affinity Conversion Mo
Externí odkaz:
https://doaj.org/article/0705162b8cf84f4caf5c09213fc12c49
Autor:
Antonio Rafael Selva Castañeda, Kalet León Monzón, Karina García Martínez, Oscar Ortiz Posada, Miguel Angel O'Farril Mateus, Soraida Candida Acosta Brooks, Mayrel Labrada Mon, Luis Enrique Bergues Cabrales, Jorge Luis García Rodríguez, Héctor Manuel Camué Ciria, Enaide Maine Calzado, Tamara Rubio González, Janet Avellanet Martínez, Arlem García Delgado, Maraelys Morales González, Daniel Jay Pérez, Emilia Ortiz Beatón, Manuel Verdecia Jarque, Victoriano Gustavo Sierra González, Dasha Fuentes Morales, Juan I. Montijano
Publikováno v:
Bioelectromagnetics. 39:460-475
Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03f3741cc64f8c2e2ef9964b0a72853
https://doi.org/10.1002/bem.22132
https://doi.org/10.1002/bem.22132
Autor:
Tania Carmenate, Kalet León, Karina García-Martínez, Luis Graca, Michel Enamorado, Ernesto Moreno, Janet Avellanet, Yaquelín Ortiz
Publikováno v:
The Journal of Immunology. 200:3475-3484
IL-2 is critical for peripheral tolerance mediated by regulatory T (Treg) cells, which represent an obstacle for effective cancer immunotherapy. Although IL-2 is important for effector (E) T cell function, it has been hypothesized that therapies bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aceb6389f652be6440a3399e9f7651
https://doi.org/10.4049/jimmunol.1700433
https://doi.org/10.4049/jimmunol.1700433
Autor:
Leonardo Mesa Torres, Mayrel Labrada Mon, Héctor Manuel Camué Ciria, Enaide Maine Calzado, Victoriano Gustavo Sierra González, Antonio Rafael Selva Castañeda, Kalet León Monzón, Jorge Luis García Rodríguez, Oscar Ortiz Posada, Daniel Jay Pérez, Arlem García Delgado, Luis Enrique Bergues Cabrales, Narciso Antonio Villar Goris, Karina García Martínez, Maraelys Morales González, Beatriz Olivares Borges, Dasha Fuentes Morales, Juan I. Montijano, Janet Avellanet Martínez
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Journal of Translational Medicine
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Journal of Translational Medicine
Background The modified Gompertz equation has been proposed to fit experimental data for direct current treated tumors when multiple-straight needle electrodes are individually inserted into the base perpendicular to the tumor long axis. The aim of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca53ca6fcb1320db2bd4db55955baea7
http://zaguan.unizar.es/record/89658
http://zaguan.unizar.es/record/89658
Publikováno v:
ProteinsREFERENCES. 89(2)
Activation of T cells triggers the expression of regulatory molecules like the programmed cell death 1 (PD1) protein. The association of PD1 with the natural ligands PDL1 and PDL2 induces an inhibitory signal that prevents T cells from proliferating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a76fc89ee3df2958794683990426f61
https://pubmed.ncbi.nlm.nih.gov/32862461
https://pubmed.ncbi.nlm.nih.gov/32862461
Publikováno v:
Journal of theoretical biology. 487
IL-1 system is involved in the induction and maintenance of chronic inflammation associated with several autoimmune diseases and cancer, mainly due to its capacity to promote the secretion of inflammatory mediators. For this reason, several intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957eaa83a511adc439414d12be2a878c
https://pubmed.ncbi.nlm.nih.gov/31830463
https://pubmed.ncbi.nlm.nih.gov/31830463
Publikováno v:
Seminars in oncology. 45(1-2)
High-dose IL2, first approved in 1992, has been used in the treatment of advanced renal cell carcinoma and melanoma. In these indications, IL2 induces long lasting objective responses in 5% to 20% of patients. However, toxicity and the unexpected exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082538add064fbb08b82763c52eed4f7
https://pubmed.ncbi.nlm.nih.gov/30318089
https://pubmed.ncbi.nlm.nih.gov/30318089
Autor:
Ernesto Moreno, Anabel Pacios, Kalet León, Dasha Fuente, Tania Carmenate, Michel Enamorado, Karina García-Martínez
Publikováno v:
The Journal of Immunology. 190:6230-6238
IL-2 has been used for the treatment of melanoma and renal cell carcinoma, but this therapy has limited efficacy and severe toxicity. Currently, it is assumed that part of the limited efficacy is due to the IL-2–driven preferential expansion of reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d6c7038cee1926f2da41ba4204d118
https://doi.org/10.4049/jimmunol.1201895
https://doi.org/10.4049/jimmunol.1201895
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 4 (2013)
Frontiers in Immunology, Vol 4 (2013)
Several reports in the literature have drawn a complex picture of the effect of treatments aiming to modulate IL2 activity in vivo. They seem to promote either immunity or tolerance, probably depending on the specific context, dose, and timing of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc908ee6cc5a7ccfedd90e14caaee9a
http://europepmc.org/articles/PMC3858650
http://europepmc.org/articles/PMC3858650
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155684 (2016)
PLoS ONE
PLoS ONE
Interleukin-2 (IL2) is a growth factor for several immune cells and its function depends on its binding to IL2Rs in the cell membrane. The most accepted model for the assembling of IL2-IL2R complexes in the cell membrane is the Affinity Conversion Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739b342938b1bf62c656103f1846518e
https://doi.org/10.1371/journal.pone.0155684
https://doi.org/10.1371/journal.pone.0155684