Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Karina F. Zoccal"'
Autor:
Mouzarllem B. Reis, Fernanda L. Rodrigues, Natalia Lautherbach, Alexandre Kanashiro, Carlos A. Sorgi, Alyne F. G. Meirelles, Carlos A. A. Silva, Karina F. Zoccal, Camila O. S. Souza, Simone G. Ramos, Alessandra K. Matsuno, Lenaldo B. Rocha, Helio C. Salgado, Luiz C. C. Navegantes, Ísis C. Kettelhut, Palmira Cupo, Luiz G. Gardinassi, Lúcia H. Faccioli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethas
Externí odkaz:
https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a
Autor:
Caio B. Abreu, Karla C. F. Bordon, Felipe A. Cerni, Isadora S. Oliveira, Carla Balenzuela, Gabriel M. Alexandre-Silva, Karina F. Zoccal, Mouzarllem B. Reis, Gisele A. Wiezel, Steve Peigneur, Ernesto L. Pinheiro-Júnior, Jan Tytgat, Tiago M. Cunha, Loic Quinton, Lúcia H. Faccioli, Eliane C. Arantes, Umberto Zottich, Manuela B. Pucca
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Scorpionism is responsible for most accidents involving venomous animals in Brazil, which leads to severe symptoms that can evolve to death. Scorpion venoms consist of complexes cocktails, including peptides, proteins, and non-protein compounds, maki
Externí odkaz:
https://doaj.org/article/304b81820cb3475fab32a23a0e518028
Autor:
Rafhaella C. A. Cedro, Danilo L. Menaldo, Tássia R. Costa, Karina F. Zoccal, Marco A. Sartim, Norival A. Santos-Filho, Lúcia H. Faccioli, Suely V. Sampaio
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-14 (2018)
Abstract Background Snake venom phospholipases A2 (PLA2s) have been reported to induce myotoxic, neurotoxic, hemolytic, edematogenic, cytotoxic and proinflammatory effects. This work aimed at the isolation and functional characterization of a PLA2 is
Externí odkaz:
https://doaj.org/article/b2c1be28f7314e39b53d19ee2f1b6118
Autor:
Gisele A. Locachevic, Morgana K. B. Prado, Karina F. Zoccal, Priscilla A. T. Pereira, Carlos A. Sorgi, Mariza Bortolanza, Ana Paula F. Peti, Manoela V. Fogaça, Francisco S. Guimarães, Elaine Del Bel, Lúcia H. Faccioli
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Depression is a mental illness with a complex and multifactorial etiology, which has been associated with stress and inflammation. Infections, autoimmune diseases, envenomation, and trauma induce an inflammatory response that is characterized by incr
Externí odkaz:
https://doaj.org/article/65ddae0a20e146afb71abc13b16a00dc
Autor:
Karina F. Zoccal, Luiz G. Gardinassi, Karla C. F. Bordon, Eliane C. Arantes, Sylvie Marleau, Huy Ong, Lúcia H. Faccioli
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Over 1 million cases of scorpion stings are estimated every year, whereas current treatment is limited to antivenom serum combined with supportive therapy. Tityus serrulatus scorpion venom (TsV) is composed of diverse molecules, including toxins that
Externí odkaz:
https://doaj.org/article/51d187fa6211407a92e65c8a6d1a5ab0
Autor:
Gabriel H. Gastaldello, Ana Caroline V. Cazeloto, Juliana C. Ferreira, Débora Munhoz Rodrigues, Jairo Kennup Bastos, Vanessa L. Campo, Karina F. Zoccal, Cristiane Tefé-Silva
Publikováno v:
Medicines, Vol 8, Iss 5, p 20 (2021)
Background: Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the e
Externí odkaz:
https://doaj.org/article/63e349198ed947d1a8876f1dd0829e3d
Autor:
Karina F. Zoccal, Carlos A. Sorgi, Juliana I. Hori, Francisco W. G. Paula-Silva, Eliane C. Arantes, Carlos H. Serezani, Dario S. Zamboni, Lúcia H. Faccioli
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Scorpion venom causes thousands of deaths worldwide. Here the authors show that the envenomation acts via prostaglandin E2 leading to inflammasome activation and lung pathology, counterbalanced by inflammation-limiting LTB4, and that COX inhibitors o
Externí odkaz:
https://doaj.org/article/e5a78ff56bba431db5aa20e5f7cb0854
Autor:
Morgana K.B. Prado, Caroline Fontanari, Camila O.S. Souza, Luiz G. Gardinassi, Karina F. Zoccal, Francisco W.G. de Paula-Silva, Ana P.F. Peti, Carlos A. Sorgi, Alyne F.G. Meirelles, Simone G. Ramos, José C. Alves-Filho, Lúcia H. Faccioli
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 865 (2020)
Histoplasma capsulatum is the agent of histoplasmosis, one of the most frequent mycoses in the world. The infection initiates with fungal spore inhalation, transformation into yeasts in the lungs and establishment of a granulomatous disease, which is
Externí odkaz:
https://doaj.org/article/77706e51097346cea81b0281ebbf5135
Autor:
Karina F. Zoccal, Luiz G. Gardinassi, Carlos A. Sorgi, Alyne F. G. Meirelles, Karla C. F. Bordon, Isaias Glezer, Palmira Cupo, Alessandra K. Matsuno, Valdes R. Bollela, Eliane C. Arantes, Francisco S. Guimarães, Lúcia Helena Faccioli
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Interleukin (IL)-1β is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus. In this context, bioactive lipids such as prostaglandin (PG)E2 and leukotriene (LT)B4 modulate the pr
Externí odkaz:
https://doaj.org/article/cdaa09a9843e475a81ad60014e7228e0
Autor:
Victor Brito, Katia Mellal, Karina F. Zoccal, Yosdel Soto, Liliane Ménard, Roger Sarduy, Lucia H. Faccioli, Huy Ong, Ana M. Vázquez, Sylvie Marleau
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The retention of lipoprotein particles in the intima, in particular to glycosaminoglycan side chains of proteoglycans, is a critical step in atherosclerosis initiation. Administration of chP3R99, a chimeric mouse/human monoclonal antibody inducing an
Externí odkaz:
https://doaj.org/article/62e2d75f3c024ff18293a15f1dde3eae