Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Karina A Serban"'
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0310524 (2024)
BackgroundAlpha-1 antitrypsin deficiency (AATD) is an inherited disease, the common variant caused by a Pi*Z mutation in the SERPINA1 gene. Pi*Z AAT increases the risk of pulmonary emphysema and liver disease. Berberine (BBR) is a nature dietary supp
Externí odkaz:
https://doaj.org/article/f305234082d546c49c349b655c6fae5b
Autor:
Karina A Serban, Daniela N Petrusca, Andrew Mikosz, Christophe Poirier, Angelia D Lockett, Lauren Saint, Matthew J Justice, Homer L Twigg, Michael A Campos, Irina Petrache
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176073 (2017)
Cigarette smoking (CS), the main risk factor for COPD (chronic obstructive pulmonary disease) in developed countries, decreases alveolar macrophages (AM) clearance of both apoptotic cells and bacterial pathogens. This global deficit of AM engulfment
Externí odkaz:
https://doaj.org/article/c6c41c5cafaf4bcd8193513623044cad
Autor:
Angelia D Lockett, Mary Beth Brown, Nieves Santos-Falcon, Natalia I Rush, Houssam Oueini, Amber J Oberle, Esther Bolanis, Miryam A Fragoso, Daniela N Petrusca, Karina A Serban, Kelly S Schweitzer, Robert G Presson, Michael Campos, Irina Petrache
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93979 (2014)
The homeostatic lung protective effects of alpha-1 antitrypsin (A1AT) may require the transport of circulating proteinase inhibitor across an intact lung endothelial barrier. We hypothesized that uninjured pulmonary endothelial cells transport A1AT t
Externí odkaz:
https://doaj.org/article/fc30a692adeb457cafbf28e54ccf3fd5
Autor:
Xiyuan Bai, An Bai, Michele Tomasicchio, James R. Hagman, Ashley M. Buckle, Arnav Gupta, Vineela Kadiyala, Shaun Bevers, Karina A. Serban, Kevin Kim, Zhihong Feng, Kathrin Spendier, Guy Hagen, Lorelenn Fornis, David E. Griffith, Monika Dzieciatkowska, Robert A. Sandhaus, Anthony N. Gerber, Edward D. Chan
Publikováno v:
The Journal of Immunology. 209:1746-1759
α1-Antitrypsin (AAT), a serine protease inhibitor, is the third most abundant protein in plasma. Although the best-known function of AAT is irreversible inhibition of elastase, AAT is an acute-phase reactant and is increasingly recognized to have a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dffd30238f9c92caa5ebbec43fd657
https://doi.org/10.4049/jimmunol.2200227
https://doi.org/10.4049/jimmunol.2200227
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Primarily caused by chronic cigarette smoking (CS), emphysema is characterized by loss of alveolar cells comprising lung units involved in gas exchange and inflammation that culminate in airspace enlargement. Dysregulation of sphingolipid metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4343e931c015ed20a81a48512f8775e0
https://doi.org/10.1152/ajplung.00017.2022
https://doi.org/10.1152/ajplung.00017.2022
Publikováno v:
Chest
COPD is a clinically heterogeneous syndrome characterized by injury to airways, airspaces, and lung vasculature and usually caused by tobacco smoke and/or air pollution exposure. COPD is also independently associated with nonpulmonary comorbidities (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130f7745cf641ef1c14b7aa17ad749f0
https://doi.org/10.1016/j.chest.2021.01.004
https://doi.org/10.1016/j.chest.2021.01.004
Autor:
Erica L. Beatman, Christophe Poirier, Danting Cao, Andrew M. Mikosz, Alexandra L. McCubbrey, Irina Petrache, Irina Bronova, Christina F Cornell, Evgeny Berdyshev, Joanna M Poczobutt, Karina A. Serban, Fabienne Gally, François Paris, Kelly S. Schweitzer
Publikováno v:
Am J Respir Cell Mol Biol
Deficiency of ASM (acid sphingomyelinase) causes the lysosomal storage Niemann-Pick disease (NPD). Patients with NPD type B may develop progressive interstitial lung disease with frequent respiratory infections. Although several investigations using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c8f3066077f7627f260556e202e5a8
https://doi.org/10.1165/rcmb.2020-0229oc
https://doi.org/10.1165/rcmb.2020-0229oc
Alpha-1-antitrypsin binds to the glucocorticoid receptor with biological significance in macrophages
Autor:
Xiyuan Bai, An Bai, Michele Tomasicchio, James R. Hagman, Ashley M. Buckle, Arnav Gupta, Vineela Kadiyala, Shaun Bevers, Karina A. Serban, Kevin Kim, Zhihong Feng, Kathrin Spendier, Guy Hagen, Lorelenn Fornis, David E. Griffith, Monika Dzieciatkowska, Robert A. Sandhaus, Anthony N. Gerber, Edward D. Chan
Alpha-1-antitrypsin (AAT), a serine protease inhibitor produced mainly by the liver, is the third most abundant protein in plasma. While a canonical receptor for AAT has not been identified, AAT can be internalized into the cytoplasm and is known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217d47a25fcc83f5cd9d45036d488c80
https://doi.org/10.1101/2022.03.11.483896
https://doi.org/10.1101/2022.03.11.483896
Autor:
Manale El Kharbili, Katja Aviszus, Sarah K. Sasse, Xiaoyun Zhao, Karina A. Serban, Susan M. Majka, Anthony N. Gerber, Fabienne Gally
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(5)
Resolution of inflammation is an active process that is tightly regulated to achieve repair and tissue homeostasis. In the absence of resolution, persistent inflammation underlies the pathogenesis of chronic lung disease such as chronic obstructive p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b15976c22e65ab46aa182ad1a40047
https://pubmed.ncbi.nlm.nih.gov/35436029
https://pubmed.ncbi.nlm.nih.gov/35436029
Autor:
Erica L. Beatman, Anna S. Bronoff, Kengo Koike, John Jung, Danting Cao, Kevin Ni, Karina A. Serban, April K. Scruggs, Irina Petrache, Andrew M. Mikosz, Evgeny Berdyshev, Irina Bronova
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 200:1113-1125
Rationale: The loss of pulmonary endothelial cells in emphysema is associated with increased lung ceramide. Ceramide perturbations may cause adaptive alterations in other bioactive sphingolipids, with pathogenic implications. We previously reported a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a31709ca6b8f32cbcfe200aa7de591d0
https://doi.org/10.1164/rccm.201812-2311oc
https://doi.org/10.1164/rccm.201812-2311oc