Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Karina A Serban"'
Autor:
Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A. Serban, Alexander Borowiec, Beatrice Babbs, Irina A. Bronova, Nicholas Egersdorf, Patrick S. Hume, Khushboo Goel, William J. Janssen, Evgeny V. Berdyshev, Carlos Cordon-Cardo, Richard Kolesnick
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear. Implicated in the pathophysiology of diverse diseases characterized by endotheli
Externí odkaz:
https://doaj.org/article/941d1f0f2b0b4a3796435b73218fab88
Autor:
Khushboo Goel, Karina A. Serban
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103973- (2022)
Externí odkaz:
https://doaj.org/article/7ff785ff351347e48a53b8cc26625254
Autor:
Xiyuan Bai, An Bai, Michele Tomasicchio, James R. Hagman, Ashley M. Buckle, Arnav Gupta, Vineela Kadiyala, Shaun Bevers, Karina A. Serban, Kevin Kim, Zhihong Feng, Kathrin Spendier, Guy Hagen, Lorelenn Fornis, David E. Griffith, Monika Dzieciatkowska, Robert A. Sandhaus, Anthony N. Gerber, Edward D. Chan
Publikováno v:
The Journal of Immunology. 209:1746-1759
α1-Antitrypsin (AAT), a serine protease inhibitor, is the third most abundant protein in plasma. Although the best-known function of AAT is irreversible inhibition of elastase, AAT is an acute-phase reactant and is increasingly recognized to have a
Autor:
Kevin Ni, Amar Gill, Victor Tseng, Andrew M. Mikosz, Kengo Koike, Erica L. Beatman, Cassie Y. Xu, Danting Cao, Fabienne Gally, Kara J. Mould, Karina A. Serban, Kelly S. Schweitzer, Keith L. March, William J. Janssen, Eva Nozik-Grayck, Stavros Garantziotis, Irina Petrache
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background Several inflammatory lung diseases display abundant presence of hyaluronic acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the extracellular matrix. The HC-HA modification is critical to neutr
Externí odkaz:
https://doaj.org/article/654e0d935cbb4a7992c5003a3c6d6685
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Primarily caused by chronic cigarette smoking (CS), emphysema is characterized by loss of alveolar cells comprising lung units involved in gas exchange and inflammation that culminate in airspace enlargement. Dysregulation of sphingolipid metabolism
Publikováno v:
Chest
COPD is a clinically heterogeneous syndrome characterized by injury to airways, airspaces, and lung vasculature and usually caused by tobacco smoke and/or air pollution exposure. COPD is also independently associated with nonpulmonary comorbidities (
Autor:
Erica L. Beatman, Christophe Poirier, Danting Cao, Andrew M. Mikosz, Alexandra L. McCubbrey, Irina Petrache, Irina Bronova, Christina F Cornell, Evgeny Berdyshev, Joanna M Poczobutt, Karina A. Serban, Fabienne Gally, François Paris, Kelly S. Schweitzer
Publikováno v:
Am J Respir Cell Mol Biol
Deficiency of ASM (acid sphingomyelinase) causes the lysosomal storage Niemann-Pick disease (NPD). Patients with NPD type B may develop progressive interstitial lung disease with frequent respiratory infections. Although several investigations using
Autor:
Karina A Serban, Daniela N Petrusca, Andrew Mikosz, Christophe Poirier, Angelia D Lockett, Lauren Saint, Matthew J Justice, Homer L Twigg, Michael A Campos, Irina Petrache
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176073 (2017)
Cigarette smoking (CS), the main risk factor for COPD (chronic obstructive pulmonary disease) in developed countries, decreases alveolar macrophages (AM) clearance of both apoptotic cells and bacterial pathogens. This global deficit of AM engulfment
Externí odkaz:
https://doaj.org/article/c6c41c5cafaf4bcd8193513623044cad
Alpha-1-antitrypsin binds to the glucocorticoid receptor with biological significance in macrophages
Autor:
Xiyuan Bai, An Bai, Michele Tomasicchio, James R. Hagman, Ashley M. Buckle, Arnav Gupta, Vineela Kadiyala, Shaun Bevers, Karina A. Serban, Kevin Kim, Zhihong Feng, Kathrin Spendier, Guy Hagen, Lorelenn Fornis, David E. Griffith, Monika Dzieciatkowska, Robert A. Sandhaus, Anthony N. Gerber, Edward D. Chan
Alpha-1-antitrypsin (AAT), a serine protease inhibitor produced mainly by the liver, is the third most abundant protein in plasma. While a canonical receptor for AAT has not been identified, AAT can be internalized into the cytoplasm and is known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217d47a25fcc83f5cd9d45036d488c80
https://doi.org/10.1101/2022.03.11.483896
https://doi.org/10.1101/2022.03.11.483896
Autor:
Manale El Kharbili, Katja Aviszus, Sarah K. Sasse, Xiaoyun Zhao, Karina A. Serban, Susan M. Majka, Anthony N. Gerber, Fabienne Gally
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(5)
Resolution of inflammation is an active process that is tightly regulated to achieve repair and tissue homeostasis. In the absence of resolution, persistent inflammation underlies the pathogenesis of chronic lung disease such as chronic obstructive p