Zobrazeno 1 - 10
of 185 644
pro vyhledávání: '"Karina A"'
Autor:
Jonathan Pacheco, Karina A. Peña, Sofya Savransky, Alexandre Gidon, Gerald R. V. Hammond, John Janetzko, Jean-Pierre Vilardaga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling. We explore this assembly by attaching fluorescent moi
Externí odkaz:
https://doaj.org/article/1ce330aebdeb49edb5e7abc9774e7bea
Autor:
Dongyang Li, Karina Al-Dahleh, Daniel A Murphy, Sonya Georgieva, Nik Matthews, Claire L Shovlin
Publikováno v:
Cell Stress, Vol 11, Pp 112-124 (2024)
Human peripheral blood mononuclear cells (PBMCs) are used to examine biological processes and disease, when basal variability in cellular activation and splicing is described and unexplained. Using isolation systems that maintained buffy coat cells (
Externí odkaz:
https://doaj.org/article/673ed9bec2f04663ad507a7927105b26
Autor:
Talita Oliveira de Lima, Karina Alexandra Batista da Silva Freitas, Karen Aline Batista da Silva, Maria Fernanda Setúbal Destro Rodrigues, Thais Barbosa dos Santos, Illora Aswinkumar Darbar Shimozato, Christiane Pavani, Rebeca Boltes Cecatto
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 1276-1286 (2024)
The main treatments for cancer are radiotherapy and chemotherapy, but they can generate side effects such as fatigue, myelosuppression, and radiodermatitis. The Multinational Association of Supportive Care in Cancer already recommends the use of lase
Externí odkaz:
https://doaj.org/article/ff7f6b9a18f6436bb394c998bca0fa12
Autor:
Aram A. Musaelyan, Svetlana V. Odintsova, Karina A. Musaelyan, Magaripa A. Urtenova, Ekaterina P. Solovyova, Lyubov I. Menshikova, Sergey V. Orlov
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 6, Pp 1271-1288 (2024)
Aim: The present study aims to evaluate the efficacy of rechallenge with immune checkpoint inhibitors (ICIs) compared to chemotherapy and the predictive role of clinical parameters in non-small cell lung cancer (NSCLC) patients who were rechallenged.
Externí odkaz:
https://doaj.org/article/8225d2e5d73e42368811cf2a42c055c3
Autor:
Paolo Oliveira-Melo, Natalia Aparecida Nepomuceno, Liliane Moreira Ruiz, Aristides Tadeu Correia, Vanessa Sana Vilela, Karina Andrighetti de Oliveira Braga, Giovana Maria Manzuti, Deymisson Damitene Martins Feitosa, Emanuel Kennedy-Feitosa, Aizhou Wang, Marcelo Cypel, Paulo Manuel Pêgo Fernandes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Brain death (BD) provides most of the donor organs destined for lung transplantation (LTx). However, the organs may be affected by inflammatory and oxidative processes. Based on this, we hypothesize that the angiotensin-converting enzyme 2 (
Externí odkaz:
https://doaj.org/article/6a6ffc43bb4141b2993b52aeba8684f5
Autor:
Paula Aparicio, David Navarrete‐Villanueva, Alba Gómez‐Cabello, Tresa López‐Royo, Enrique Santamaría, Joaquín Fernández‐Irigoyen, Karina Ausín, Manuel Arruebo, Victor Sebastian, Germán Vicente‐Rodríguez, Rosario Osta, Raquel Manzano
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1883-1897 (2024)
Abstract Background Sarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications. Despite the extensive
Externí odkaz:
https://doaj.org/article/d1f9518606374239b3f7f8bf3ae2919c
Autor:
Karina Ayumi Martins Utida, Denise Cruz Carvalho Gomes, Fábio de Souza Ajala, Paula Felippe Martinez, Silvio Assis de Oliveira-Junior
Publikováno v:
Human Movement, Vol 25, Iss 3, Pp 62-71 (2024)
Purpose We investigated injury rates over the previous 12 months, associated factors, and injury characteristics in a cohort of recreational functional fitness training participants. Methods A cross-sectional study was conducted with a convenience s
Externí odkaz:
https://doaj.org/article/50c71aa9f62f486f992c01e8ba0dac72
Publikováno v:
Proceedings on Engineering Sciences, Vol 6, Iss 3, Pp 1127-1136 (2024)
This paper elaborates on the role of higher education in knowledge management in the conditions of the digital economy, considers challenges and prospects connected with the digital transformation of economy and society and the necessity for the form
Externí odkaz:
https://doaj.org/article/b60ef6f51c8146c19a4fe0d548b565f6
Autor:
Benjamin D. Seadler, MD, Nathan J. Smith, MD, Adhitya Ramamurthi, MD, James Zelten, MS, Karina Alagoa, BS, Lyle D. Joyce, MD PhD, David L. Joyce, MD MBA
Publikováno v:
Surgery Open Science, Vol 20, Iss , Pp 136-139 (2024)
Background: The optimal training program to transform a new resident into a competent and capable surgeon is constantly evolving. Competency-based evaluation represents a change in mindset from quantitative or chronologic metrics for graduate readine
Externí odkaz:
https://doaj.org/article/32f9308975024e5789c81f0b093f7e88
Autor:
Luisa Chocarro, Ester Blanco, Leticia Fernandez-Rubio, Maider Garnica, Miren Zuazo, Maria Jesus Garcia, Ana Bocanegra, Miriam Echaide, Colette Johnston, Carolyn J Edwards, James Legg, Andrew J Pierce, Hugo Arasanz, Gonzalo Fernandez-Hinojal, Ruth Vera, Karina Ausin, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Grazyna Kochan, David Escors
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1791-1816 (2024)
Abstract Many cancer patients do not benefit from PD-L1/PD-1 blockade immunotherapies. PD-1 and LAG-3 co-upregulation in T-cells is one of the major mechanisms of resistance by establishing a highly dysfunctional state in T-cells. To identify shared
Externí odkaz:
https://doaj.org/article/28ff1b0ab6c0455fbce072272578f5f4