Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Karina, Wong"'
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Akademický článek
Discordance in HER2 gene amplification in circulating and disseminated tumor cells in patients with operable breast cancer
Autor: Savitri Krishnamurthy, Farideh Bischoff, Julie Ann Mayer, Karina Wong, Tam Pham, Henry Kuerer, Ashutosh Lodhi, Anirban Bhattacharyya, Carolyn Hall, Anthony Lucci
Publikováno v: Cancer Medicine, Vol 2, Iss 2, Pp 226-233 (2013)
Abstract Human epidermal growth factor receptor 2 (HER2) gene amplification in circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) might be useful for modifying Herceptin therapy in breast cancer. In the process of investigating the ut
Externí odkaz: https://doaj.org/article/bbf857e3fc3d47afbc4892cd4fb082f8
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2
Discovery of (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch
Autor: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
Publikováno v: Journal of Medicinal Chemistry. 56:5261-5274
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201
https://doi.org/10.1021/jm301741t
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3
A Novel Platform for Detection of CK+ and CK− CTCs
Autor: Justin Bottsford-Miller, Cathy Eng, Rebecca L. Stone, Blake W. Goodman, Padmavathi Jaladurgam, Anil K. Sood, Stephen D. Mikolajczyk, J. A. Mayer, Chad V. Pecot, Farideh Z. Bischoff, Alpa M. Nick, Tam Pham, Michael T. Deavers, Joseph Celestino, Lee M. Ellis, William M. Merritt, Ju Won Roh, Karina Wong, Yvonne G. Lin, Tony J. Pircher
Publikováno v: Cancer Discovery. 1:580-586
Metastasis is a complex, multistep process that begins with the epithelial–mesenchymal transition (EMT). Circulating tumor cells (CTC) are believed to have undergone EMT and thus lack or express low levels of epithelial markers commonly used for en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fc6a793caff73021df2ba4f7340fda
https://doi.org/10.1158/2159-8290.cd-11-0215
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7
N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase
Autor: Karina Wong, Erich Goldbach, Gary Probst, John-Michael Sauer, Andrei W. Konradi, Michael P. Bova, Hing L. Sham, Susanna S. Hemphill, Kevin P. Quinn, Guriqbal S. Basi, Simeon Bowers, Anh P. Truong, William Wallace, Roy K. Hom, Lan K. Nguyen, Albert W. Garofalo
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6952-6956
The structural modification of a series of [3.3.1] bicyclic sulfonamide based gamma-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0f68b5faee06e48ea31b81668abdf3
https://doi.org/10.1016/j.bmcl.2009.10.060
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8
P4-06-04: Detection of HER2 Gene Amplification in Circulating Tumor Cells and Disseminated Tumor Cells by Fluorescence In Situ Hybridization Using OncoCEE™
Autor: Anthony Lucci, Tam Pham, A. Lodhi, A. Bhattacharyya, H. M. Kuerer, Karina Wong, Savitri Krishnamurthy, Farideh Z. Bischoff, J. A. Mayer, Carolyn S. Hall
Publikováno v: Cancer Research. 71:P4-06
BACKGROUND: The status of HER2 gene amplification in circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) might provide useful information for monitoring response to trastuzumab therapy, and may provide a basis for consideration of tras
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2ae1bf48ef5a9980aa8436e775e5f6f
https://doi.org/10.1158/0008-5472.sabcs11-p4-06-04
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9
Correlation of hormone receptor status between circulating tumor cells, primary tumor, and metastasis in breast cancer patients
Autor: Karina Wong, Matthew Maurer, Eligie Villarin, Julie Ann Mayer, Tony J. Pircher, Xunhai Xu, Farideh Z. Bischoff, Tam Pham, Mindy Brown, Kevin Kalinsky
Publikováno v: Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 17(7)
Estrogen receptor (ER) and progesterone receptor (PR) status is prognostic and predictive in breast cancer. Because metastatic breast tumor biopsies are not routinely feasible, circulating tumor cells (CTCs) offer an alternative source of determining
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88be32c7569d9af77cb4d317c2831ecf
https://pubmed.ncbi.nlm.nih.gov/25613123
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10
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch
Autor: Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi
Publikováno v: Journal of medicinal chemistry. 56(13)
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::109e2b6e92821a752624dca210f7b056
https://pubmed.ncbi.nlm.nih.gov/23713656
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