Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Karina, Eiwen"'
Autor:
Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSC). We report increased frequencies of HSC, hematopoietic progenitor cells and lineage negative cells in the elderly but a decreased frequency of multi-lymphoi
Externí odkaz:
https://doaj.org/article/f412a1c316754eae9e008f8f750efa0f
Autor:
Andreas Brown, Desiree Schuetz, Yang Han, Deidre Daria, Kalpana J. Nattamai, Karina Eiwen, Vadim Sakk, Johannes Pospiech, Thomas Saller, Gary van Zant, Wolfgang Wagner, Hartmut Geiger
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/a8b73ebd065f46b89fa1a0c24c629585
Autor:
Andreas Brown, Johannes Pospiech, Karina Eiwen, Darren J. Baker, Bettina Moehrle, Vadim Sakk, Kalpana Nattamai, Mona Vogel, Ani Grigoryan, Hartmut Geiger
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1359-1368 (2017)
Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells. While leukemia is frequently driven by transformed hematopoietic stem a
Externí odkaz:
https://doaj.org/article/a94c74c4e25547e693b8eccc7440ef5e
Autor:
Karina Eiwen, Ani Grigoryan, Yi Zheng, Katharina Senger, Matthias Gaestel, Karin Soller, Tanja Schuster, Vadim Sakk, Hartmut Geiger, Manoj B. Menon, Ravinder Kandi, Maria Carolina Florian
Publikováno v:
EMBO Reports
Aging of hematopoietic stem cells (HSCs) is caused by the elevated activity of the small RhoGTPase Cdc42 and an apolar distribution of proteins. Mechanisms by which Cdc42 activity controls polarity of HSCs are not known. Binder of RhoGTPases proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eb17481e17b8d4e0801fad890bef99
http://europepmc.org/articles/PMC8647144
http://europepmc.org/articles/PMC8647144
Autor:
Michael W.M. Kühn, Lars Bullinger, Stefan Gröschel, Jan Krönke, Jennifer Edelmann, Frank G. Rücker, Karina Eiwen, Peter Paschka, Verena I. Gaidzik, Karlheinz Holzmann, Richard F. Schlenk, Hartmut Döhner, Konstanze Döhner
Publikováno v:
Haematologica, Vol 99, Iss 8 (2014)
Externí odkaz:
https://doaj.org/article/0c20b1f7ca8d489e8593334d7c2e8a51
Autor:
Schuster T, Yi Zheng, Katharina Senger, Sakk, Karin Soller, Manoj B. Menon, Hartmut Geiger, Karina Eiwen, Kandi R, Ani Grigoryan, Carolina Florian M, Matthias Gaestel
Aging of hematopoietic stem cells (HSCs) is caused by an elevated activity of the small RhoGTPase Cdc42 and an apolar distribution of proteins. Mechanisms by which Cdc42 activity controls polarity of HSCs are not known. Binder of RhoGTPases proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b35f36457d5d78b46c9b45ce371f2d
https://doi.org/10.1101/2021.03.17.435817
https://doi.org/10.1101/2021.03.17.435817
Autor:
Ramiz Emini, Vadim Sakk, Markus Hoenicka, Karina Eiwen, Angelika Vollmer, Andreas Liebold, Maria Carolina Florian, Anja Keller, Hartmut Geiger, Karin Soller, Amanda Amoah, Yi Zheng
Publikováno v:
Haematologica. 107(2)
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSC). We report increased frequencies of HSC, hematopoietic progenitor cells and lineage negative cells in the elderly but a decreased frequency of multi-lymphoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9381f2f8b69aa7adc6dee1c1bd3436
https://pubmed.ncbi.nlm.nih.gov/33440922
https://pubmed.ncbi.nlm.nih.gov/33440922
Autor:
Vadim Sakk, Hartmut Geiger, Desiree Schuetz, Deidre Daria, Johannes Pospiech, Wolfgang Wagner, Karina Eiwen, Yang Han, Thomas Saller, Gary Van Zant, Andreas Brown, Kalpana Nattamai
Publikováno v:
Haematologica 105(2), 317-324 (2020). doi:10.3324/haematol.2018.213009
Haematologica 105(2), 317-324 (2020). doi:10.3324/haematol.2018.213009
Published by Ferrata Storti Foundation42382, Pavia
Published by Ferrata Storti Foundation42382, Pavia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fc598dea4390c12a28ea601d63d198
https://publications.rwth-aachen.de/record/784644
https://publications.rwth-aachen.de/record/784644
Autor:
Reinhold Schirmbeck, Vadim Sakk, Hanna Leins, Medhanie A. Mulaw, Michael Denkinger, Ying Liang, Karina Eiwen, Hartmut Geiger
Publikováno v:
Blood. 132:565-576
Aging-associated remodeling of the immune system impairs its functional integrity and contributes to increased morbidity and mortality in the elderly. Aging of hematopoietic stem cells (HSCs), from which all cells of the adaptive immune system ultima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db81f0d97fb209a7661307f9d2a043e3
https://doi.org/10.1182/blood-2018-02-831065
https://doi.org/10.1182/blood-2018-02-831065
Autor:
Karin Soller, Tanja Weil, Jose A. Cancelas, Novella Guidi, Johannes M. Weiss, Ludger Ständker, Gina Marka, Frank Kirchhoff, Hartmut Geiger, Karina Eiwen, Maria Carolina Florian, Mehmet Sacma
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal
Upon aging, hematopoietic stem cells (HSCs) undergo changes in function and structure, including skewing to myeloid lineages, lower reconstitution potential and loss of protein polarity. While stem cell intrinsic mechanisms are known to contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c6b80412477038cc8e3c62bc7c543b
http://europepmc.org/articles/PMC5376966
http://europepmc.org/articles/PMC5376966