Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto–Kakizaki (GK) rats: ameliorating effects of (−)-epigallocatechin-3-gallate

Autor: Jiangang Long, Jiong Yan, Jia Liu, Weili Shen, Karin Wertz, Jiankang Liu, Peter Weber, Ying Wang, Zhihui Feng

Publikováno v: The Journal of Nutritional Biochemistry. 23:716-724

Oxidative stress and mitochondrial dysfunction are known to play important roles in type 2 diabetes mellitus (T2DM) and insulin resistance. However, the pathology of T2DM remains complicated; in particular, the mechanisms of mitochondrial dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f942fd4e0e455a73f49b916aa72da7
https://doi.org/10.1016/j.jnutbio.2011.03.014

Lycopene bioavailability and metabolism in humans: an accelerator mass spectrometry study

Autor: Karin Wertz, Alexandre Bourgeois, Paul L. Skipper, Myriam Richelle, Rosa G. Liberman, Inge Lise F. Nielsen, Marc Enslen, Steven R. Tannenbaum, Hans-Arno Synal, Gary Williamson, Sunil Kochhar, Tim Schulze-König, Philippe A. Guy, Laurent B. Fay, Jon L. Ruckle, Alastair B. Ross, Robert Rümbeli, Le Thuy Vuong

Publikováno v: The American Journal of Clinical Nutrition. 93:1263-1273

Background To our knowledge, there is no direct information on lycopene metabolism in humans. Objective The objective of this study was to quantify the long-term human bioavailability of lycopene in plasma and skin after a single dose of (14)C-lycope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df629cca1e7cfe9f8ca8925c55e06d1
https://doi.org/10.3945/ajcn.110.008375

Identification of Distinct Topographical Surface Microstructures Favoring Either Undifferentiated Expansion or Differentiation of Murine Embryonic Stem Cells

Autor: Annette Füchtbauer, Lotte Markert, Ernst-Martin Füchtbauer, Finn Skou Pedersen, Jette Lovmand, Flemming Besenbacher, Morten Foss, Rune Hoff Lauridsen, Mogens Duch, Karin Wertz, Michael Lovmand

Publikováno v: Markert, L DA, Lovmand, J, Foss, M, Lauridsen, R H, Lovmand, M, Füchtbauer, E-M, Füchtbauer, A, Wertz, K, Besenbacher, F, Pedersen, F S & Duch, M 2009, ' Identification of distinct topographical surface microstructures favoring either undifferentiated expansion or differentiation of murine embryonic stem cells ', Stem Cells and Development, vol. 18, no. 9, pp. 1331-42 . https://doi.org/10.1089/scd.2009.0114

Udgivelsesdato: 2009-Nov The potential of embryonic stem (ES) cells for both self-renewal and differentiation into cells of all three germ layers has generated immense interest in utilizing these cells for tissue engineering or cell-based therapies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbacd6961398029e5776aa11a707436
https://doi.org/10.1089/scd.2009.0114

β-Carotene-Induced Changes in RARβ Isoform mRNA Expression Patterns Do Not Influence Lung Adenoma Multiplicity in the NNK-Initiated A/J Mouse Model

Autor: Regina Goralczyk, Karin Wertz, Heinrich Bachmann, Petra Buchwald Hunziker, Claude-Pierre Aebischer, Brad Greatrix, Barbara Lenz, Georges Riss

Publikováno v: Nutrition and Cancer. 54:252-262

Dietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathways. Dietary item or component studied: beta-carotene Outcome studied: lung adenoma; gene regulation of the putative tumor suppressor RARbeta in mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ceda358138ff89a077945be0a711ac
https://doi.org/10.1207/s15327914nc5402_12

The effect of β-carotene and its derivatives on cytotoxicity, differentiation, proliferative potential and apoptosis on the three human acute leukemia cell lines: U-937, HL-60 and TF-1

Autor: Aleksander B. Skotnicki, Marek Bodzioch, Karin Wertz, Thomas Langmann, Magdalena Zawada, Zofia Lach, Edyta Zdziƚowska, Christopher Moele, Anna Polus, Marta Libura, Jadwiga Hartwich, Tomasz Sacha, Marta Szostek, Georges Riss, Gerd Schmitz, Aldona Dembińska-Kieć, Regina Goralczyk

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1740:206-214

The influence of β-carotene (BC) and its derivatives on differentiation, proliferation and apoptosis in three human acute leukemia cell lines was studied. We investigated: (i) the cellular uptake of BC, (ii) the cytotoxicity, (iii) the effect on cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e7066781cc07fae716d474674dabbb
https://doi.org/10.1016/j.bbadis.2004.12.005