Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Karin Weigelt"'
Publikováno v:
BioTechniques, Vol 45, Iss 2, Pp 131-140 (2008)
Although ChIP-chip is a powerful tool for genome-wide discovery of transcription factor target genes, the steps involving raw data analysis, identification of promoters, and correlation with binding sites are still laborious processes. Therefore, we
Externí odkaz:
https://doaj.org/article/2423ac24a85e461286ca587e35531bad
Autor:
Lucy Baldeón R, Karin Weigelt, Harm de Wit, Behiye Ozcan, Adri van Oudenaren, Fernando Sempértegui, Eric Sijbrands, Laura Grosse, Anton-Jan van Zonneveld, Hemmo A Drexhage, Pieter J M Leenen
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129421 (2015)
To study the expression pattern of microRNAs and mRNAs related to inflammation in T2D monocytes.A microRNA finding study on monocytes of T2D patients and controls using array profiling was followed by a quantitative Real Time PCR (qPCR) study on mono
Externí odkaz:
https://doaj.org/article/89a7614d74084e56a4d2674898183a20
Autor:
Lucy Baldeón R, Karin Weigelt, Harm de Wit, Behiye Ozcan, Adri van Oudenaren, Fernando Sempértegui, Eric Sijbrands, Laura Grosse, Wilma Freire, Hemmo A Drexhage, Pieter J M Leenen
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115209 (2014)
There is increasing evidence that chronic inflammation is an important determinant in insulin resistance and in the pathogenesis of type 2 diabetes (T2D). MicroRNAs constitute a newly discovered system of cell regulation and in particular two microRN
Externí odkaz:
https://doaj.org/article/5dc645a9d852445dbe309992ec007cda
Autor:
Sabine Bahn, Nitin Rustogi, Jason D. Cooper, Santiago G. Lago, David Alan Cox, F. Markus Leweke, Hemmo A. Drexhage, Karin Weigelt, Jakub Tomasik, Sureyya Ozcan, Geertje F. van Rees
Publikováno v:
Brain Behavior & Immunity, 67, 364-373. Academic Press
Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. Previously the pathophysiology of microglial activation was considered to be intrinsic to the central nervous system. We hypothesised that due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ea452dcf8d2ec6622fef6373b91347
https://pure.eur.nl/en/publications/5bbd0f91-834f-4aba-a64c-ab4239d347ef
https://pure.eur.nl/en/publications/5bbd0f91-834f-4aba-a64c-ab4239d347ef
Autor:
Lucy Baldeón Rojas, Hemmo A. Drexhage, Behiye Özcan, Anton Jan van Zonneveld, Pieter J. M. Leenen, Harm de Wit, Karin Weigelt, Adri van Oudenaren, Fernando Sempértegui, Laura Grosse, Eric J.G. Sijbrands
Publikováno v:
Diabetology and Metabolic Syndrome, 8
Diabetology & Metabolic Syndrome
DIABETOLOGY & METABOLIC SYNDROME, 8. BioMed Central Ltd.
Diabetology & Metabolic Syndrome
DIABETOLOGY & METABOLIC SYNDROME, 8. BioMed Central Ltd.
Background Recently, we reported signs of inflammation (raised IL-8, reduced miR-146a) and signs of vascular repair (raised HGF) in the serum of Ecuadorian patients with type 2 diabetes (T2D). In contrast, we found that the circulating monocytes lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88da2e86ff2353d6774d35082e908c8c
https://doi.org/10.1186/s13098-015-0113-5
https://doi.org/10.1186/s13098-015-0113-5
Autor:
Nico J.M. van Beveren, Hemmo A. Drexhage, Karin Weigelt, Roos C. Drexhage, Livia A. Carvalho, Annemarie J. M. Wijkhuijs, Harm de Wit, Veerle Bergink, Tom K. Birkenhäger
Publikováno v:
Brain, Behavior, and Immunity; Vol 25
Brain Behavior & Immunity, 25(6), 1162-1169. Academic Press
Brain Behavior & Immunity, 25(6), 1162-1169. Academic Press
Introduction: Immune activation is a characteristic of schizophrenia (SCZ), bipolar disorder (BD) and unipolar major depressive disorder (MDD). The triggering receptor expressed on myeloid cells 1 (TREM-1), its' adaptor molecule DAP12 and their trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffc271c1ce8b5e558c4448b686e96d6
Autor:
Heinz Schwer, Jan Van den Brulle, Karin Weigelt, Yana Walczak, Rudolf Fuchshofer, Stefanie Ebert, Marcus Karlstetter, Thomas Langmann
Publikováno v:
The Journal of Immunology. 185:3379-3390
Microgliosis is a common phenomenon in neurodegenerative disorders, including retinal dystrophies. To identify candidate genes involved in microglial activation, we used DNA-microarray analysis of retinal microglia from wild-type and retinoschisin-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d24bacc8249a53bd35747ec6593145
https://doi.org/10.4049/jimmunol.0903300
https://doi.org/10.4049/jimmunol.0903300
Autor:
Markus U. Ehrengruber, Bernhard H. F. Weber, Karin Weigelt, Thorsten Stiewe, Stefanie Ebert, Thomas Langmann, Yana Walczak
Publikováno v:
NeuroMolecular Medicine. 11:87-96
We have previously identified activation of microglia and induction of the early growth response gene 1 (Egr1) in the retina of retinoschisin-deficient (Rs1h(-/Y)) mice. We hypothesized that microglial expression of Egr1 might support retinal microgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd9f7b18c55ceb03ed4c9609c627050
https://doi.org/10.1007/s12017-009-8061-6
https://doi.org/10.1007/s12017-009-8061-6
Publikováno v:
Biochemical and Biophysical Research Communications. 380:308-312
PU.1 is a key transcription factor for hematopoiesis and macrophage differentiation. Using chromatin immunoprecipitation we have previously identified several PU.1 target genes in macrophages and microglia. With the aim to complement these studies, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb686f58bd5e7ce79aed15af1554b03
https://doi.org/10.1016/j.bbrc.2009.01.067
https://doi.org/10.1016/j.bbrc.2009.01.067
Autor:
Katharina Stoecker, Yana Walczak, Stefanie Ebert, Marcus Karlstetter, Thomas Langmann, Karin Weigelt
Publikováno v:
Biochemical and Biophysical Research Communications. 379:121-126
Activated microglia contribute to neurodegenerative processes in the brain and the retina. Via DNA-microarray analysis, we have previously identified up-regulation of several immune-related genes in the dystrophic retina of retinoschisin-deficient (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196f45abff78b2cafc7f04ee8ea6fbf6
https://doi.org/10.1016/j.bbrc.2008.12.021
https://doi.org/10.1016/j.bbrc.2008.12.021