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of 7
pro vyhledávání: '"Karin W.M. Zuurbier"'
Autor:
Sharon Wolters, Johannes A. Carpay, Marja H. Pronk, Karin W.M. Zuurbier, Maurice T. Driessen, Leonidas Lyras, Maarten J. Postma
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Chronic migraine (CM) is the most severe and burdensome subtype of migraine. Fremanezumab is a monoclonal antibody that targets the calcitonin gene-related peptide pathway as a migraine preventive therapy. This study aimed to cond
Externí odkaz:
https://doaj.org/article/681ee1e23e7d45ba81d6625161f93c38
Autor:
Karin W.M. Zuurbier, Robert Verpoorte, Robert van der Heijden, Johannes J. C. Scheffer, Suen-Ying Fung, Norma Paniego
Publikováno v:
European Journal of Biochemistry. 262:612-616
Phlorisovalerophenone synthase (VPS), a novel aromatic polyketide synthase, was purified to homogeneity from 4.2 mg protein extract obtained from hop (Humulus lupulus L.) cone glandular hairs. The enzyme uses isovaleryl-CoA or isobutyryl-CoA and thre
Autor:
Karin W.M. Zuurbier, Johannes J. C. Scheffer, Suen-Ying Fung, Norma Paniego, Robert Verpoorte
Publikováno v:
Phytochemistry. 44:1047-1053
In the final step of the biosynthesis of hop bitter acids an oxidation leads to the formation of α-acids. A method was set up to analyse the bitter acids in the presence of proteins, since proteins from a crude hop extract were found to interact wit
Publikováno v:
Phytochemistry. 38:77-82
A new hypothesis concerning the formation of aromatic intermediates in the biosynthesis of hop bitter acids was tested. Two phloroglucinol derivatives, 2-(3-methylbutanoyl)-1,3,5-benzenetriol (phlorisovalerophenone = PIVP) and 2-(2-methylpropanoyl)-1
Publikováno v:
Phytochemistry. 34:1225-1229
An assay of chalcone synthase activity based upon analysis by HPLC has been developed. The method is specific (identification of the product formed), f
Publikováno v:
ChemInform. 30
Bitter acids are accumulated in the glandular hairs of hop cones. The first step of the biosynthesis of the bitter acids, namely formation of the aromatic intermediates, is catalysed by a chalcone synthase-like enzyme. In the present paper two sequen
Autor:
Jürgen Leser, Gudrun Schröder, Joachim Schröder, Robert Verpoorte, Thorsten Berger, Karin W.M. Zuurbier, Albertus J.P Hofte
Publikováno v:
Phytochemistry. 49(7)
Valerophenone synthase (VPS) is a polyketide synthase that catalyzes the formation of the phloroglucinol derivatives in the synthesis of the bitter acids in hop (Humulus lupulus). The reaction uses isovaleryl-CoA or isobutyryl-CoA, but otherwise it i