Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Karin Vargova"'
Autor:
Karin Vargova, Emanuel Necas, Jana Rybarova, Tomas Stopka, Juraj Kokavec, Vit Pospisil, Filipp Savvulidi, Anna Jonasova, Peter Laslo, Jiri Zavadil
Publikováno v:
The EMBO Journal. 30:4450-4464
The oncogenic cluster miR-17-92 encodes seven related microRNAs that regulate cell proliferation, apoptosis and development. Expression of miR-17-92 cluster is decreased upon cell differentiation. Here, we report a novel mechanism of the regulation o
Autor:
Petra Basova, Vojtech Kulvait, Šárka Pospíšilová, Josef Karban, Nikola Curik, Vit Pospisil, Emanuel Necas, Marek Mráz, Jiri Zavadil, Petra Obrtlikova, Tomas Stopka, Marek Trneny, Jiri Mayer, Karin Vargova, Filipp Savvulidi, Pavel Burda, Adela Berkova, Juraj Kokavec
Publikováno v:
Blood. 117:3816-3825
Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL pat
Autor:
Karin Vargova, Anna Jonasova, Pavel Burda, Nikola Curik, Filipp Savvulidi, Tomas Zikmund, Tomas Stopka, Martina Kapalova
Publikováno v:
Blood. 120:3848-3848
Abstract 3848 Introduction: 5-azacitidine (AZA) represents very promising albeit not fully efficient therapy for int-2 and high risk MDS patients. Molecules that interfere with AZA therapy are not known. In significant proportion of MDS patients, PU.
Autor:
Tomas Stopka, Libor Stanek, Filipp Savvulidi, Martina Kapalova, Ulrich Steidl, Karin Vargova, Pavel Burda, Petra Vlckova
Publikováno v:
Blood. 120:769-769
Abstract 769 Introduction: Downregulation of tumour suppressor transcription factor PU.1 in haematopoietic stem and progenitor cells represents primary underlying mechanism for the development of acute myeloid leukaemia (AML) in mice with homozygous
Publikováno v:
Blood. 118:4624-4624
Abstract 4624 Mantle cell lymphoma (MCL) represents B-cell lymphoma derived from the mantle zone that surrounds normal germinal center follicles. Pathophysiology of this hardly curable disease involves t(11,14)(q13,q32) translocation which leads to u
Autor:
Emanuel Necas, Karin Vargova, Marek Trneny, Vojtech Kulvait, Pavel Burda, Hana Huskova, Petra Obrtlikova, Petra Vlckova, Šárka Pospíšilová, Marek Mráz, Nikola Curik, Filipp Savvulidi, Jiri Mayer, Vit Pospisil, Tomas Stopka, Josef Karban
Publikováno v:
Blood. 118:4600-4600
Abstract 4600 MicroRNA miR-155 represents a candidate pathogenic factor in chronic lymphocytic leukemia (CLL) and lymphomas (Eis PS, et al. 2005, Fulci V, et al. 2007, Calin GA, et al. 2005, Kluiver J, et al. 2005, Metzler M, et al. 2004, van den Ber
Autor:
Vit Pospisil, Josef Karban, Adela Berkova, Vojtech Kulvait, Petra Obrtlikova, Tomas Stopka, Karin Vargova, Petra Basova, Emanuel Necas, Pavel Burda, Filipp Savvulidi, Jiri Zavadil, Nikola Curik, Marek Trneny
Publikováno v:
ResearcherID
Abstract 3589 Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In our study, B-CLL patients (N=71, F/M 31/40, median age 65) were subject to molecular analyses that found significa
Autor:
Karin Vargova, Emanuel Necas, Jiri Zavadil, Jana Rybarova, Tomas Stopka, Peter Laslo, Filipp Savvulidi, Juraj Kokavec, Vit Pospisil
Publikováno v:
ResearcherID
Abstract 390 The miR-17-92 cluster (Oncomir1) encodes seven related microRNAs associated with cell proliferation, apoptosis and development and is overexpressed in number of malignancies including myeloid leukemias. The miR-17-92 cluster is highly ex
Autor:
Tomas Stopka, Marek Trneny, Petra Basova, Nikola Curik, Anna Jonasova, Karin Vargova, Pavel Burda
Publikováno v:
ResearcherID
Abstract 124 The myelodysplastic syndrome (MDS) represents a heterogeneous disorder characterized by ineffective hematopoiesis and evolution to acute myelogenous leukemia that is strikingly refractory to current therapeutic approaches. Novel epigenet
Autor:
Arthur I. Skoultchi, Karin Vargova, Nikola Curik, Pavel Burda, Juraj Kokavec, Jiri Zavadil, Tomas Stopka, Jarmila Podskocova
Publikováno v:
Blood. 112:4759-4759
Gata1 is transcription factor that regulates erythropoiesis and its direct interaction with chromatin remodeling protein Snf2h may affect chromatin structure (Rodriguez 2005). Snf2h belongs to SWI/SNF2 superfamily of ATPases regulating structure of n