Výsledky vyhledávání - "Karin Stadlbauer"

Akademický článek

55P0110, a Novel Synthetic Compound Developed from a Plant Derived Backbone Structure, Shows Promising Anti-Hyperglycaemic Activity in Mice.

Autor: Barbara Brunmair, Zsuzsanna Lehner, Karin Stadlbauer, Immanuel Adorjan, Klaus Frobel, Thomas Scherer, Anton Luger, Leonhardt Bauer, Clemens Fürnsinn

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126847 (2015)

Starting off with a structure derived from the natural compound multiflorine, a derivatisation program aimed at the discovery and initial characterisation of novel compounds with antidiabetic potential. Design and discovery of the structures was guid

Externí odkaz: https://doaj.org/article/cfb83a19a408451387640ce906788fe1

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Evidence that the multiflorine‐derived substituted quinazolidine 55P0251 augments insulin secretion and lowers blood glucose via antagonism at α 2 ‐adrenoceptors in mice

Autor: Immanuel Adorjan, Leonhardt Bauer, Clemens Fürnsinn, Karin Stadlbauer, B. Brunmair, Thomas Scherer, Miroslav Genov, Zsuzsanna Lehner, Alexandra Kautzky-Willer, Mika Scheinin

Publikováno v: Diabetes, Obesity & Metabolism

Aims To investigate the mechanism of action of 55P0251, a novel multiflorine‐derived substituted quinazolidine that augments insulin release and lowers blood glucose in rodents, but does not act via mechanisms addressed by any antidiabetic agent in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6b45da0afccda987f504e676565d5c
https://doi.org/10.1111/dom.13895

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Preclinical characterization of 55P0251, a novel compound that amplifies glucose-stimulated insulin secretion and counteracts hyperglycaemia in rodents

Autor: Leonhardt Bauer, Zsuzsanna Lehner, Anton Luger, Clemens Fürnsinn, Karin Stadlbauer, B. Brunmair, Thomas Scherer, Immanuel Adorjan

Publikováno v: Diabetes, Obesity and Metabolism. 19:1088-1096

Aims 55P0251 is a novel compound with blood glucose lowering activity in mice, which has been developed from a molecular backbone structure found in herbal remedies. We here report its basic pharmacological attributes and initial progress in unmaskin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a6747d72993e7af6e1f84981b003c6d
https://doi.org/10.1111/dom.12914

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Author response for 'Evidence that the multiflorine derived substituted quinazolidine 55P0251 augments insulin secretion and lowers blood glucose, via antagonism at α 2 ‐adrenoceptors in mice'

Autor: Miroslav Genov, Zsuzsanna Lehner, Barbara Brunmair, Karin Stadlbauer, Mika Scheinin, Leonhardt Bauer, Immanuel Adorjan, Alexandra Kautzky-Willer, Clemens Fürnsinn, Thomas Scherer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f9b7c20b84b6d70899e4b5d41a6e44
https://doi.org/10.1111/dom.13895/v4/response1

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Preclinical characterization of 55P0251, a novel compound that amplifies glucose-stimulated insulin secretion and counteracts hyperglycaemia in rodents

Autor: Karin, Stadlbauer, Barbara, Brunmair, Zsuzsanna, Lehner, Immanuel, Adorjan, Thomas, Scherer, Anton, Luger, Leonhardt, Bauer, Clemens, Fürnsinn

Publikováno v: Diabetes, obesitymetabolism. 19(8)

55P0251 is a novel compound with blood glucose lowering activity in mice, which has been developed from a molecular backbone structure found in herbal remedies. We here report its basic pharmacological attributes and initial progress in unmasking the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cba1c35dc9ebfd1e849c40fb1c942be
https://pubmed.ncbi.nlm.nih.gov/28211608

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Lipophilicity as a determinant of thiazolidinedione action in vitro: findings from BLX-1002, a novel compound without affinity to PPARs

Autor: Karin Stadlbauer, B. Brunmair, Clemens Fürnsinn, Zsuzsanna Lehner, Katrin Staniek, Charles W. Bolten, Debendranath Dey, Anton Luger

Publikováno v: American Journal of Physiology-Cell Physiology. 300:C1386-C1392

The pharmacology of thiazolidinediones (TZDs) seems to be driven not only by activation of peroxisome proliferator-activated receptor-γ (PPARγ), but also by PPARγ-independent effects on mitochondrial function and cellular fuel handling. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e9656bdeea37e22d139f3dd3b1958a
https://doi.org/10.1152/ajpcell.00401.2010

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Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver

Autor: Christian Anderwald, Michael Roden, Michael Krebs, Clemens Fürnsinn, Karin Stadlbauer, B. Brunmair

Publikováno v: European Journal of Clinical Investigation. 37:774-782

Background Elevated circulating free fatty acids (FFAs) induce insulin resistance and play a crucial role in the development of type 2 diabetes, in which fasting hepatic glucose production (HGP) is increased. However, direct effects of FFAs on fastin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4feb7dfc657d3d0ab31f4c48ca62fd5
https://doi.org/10.1111/j.1365-2362.2007.01858.x

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55P0110, a Novel Synthetic Compound Developed from a Plant Derived Backbone Structure, Shows Promising Anti-Hyperglycaemic Activity in Mice

Autor: Clemens Fürnsinn, Zsuzsanna Lehner, Klaus Frobel, Anton Luger, Immanuel Adorjan, Leonhardt Bauer, Karin Stadlbauer, B. Brunmair, Thomas Scherer

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126847 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e98558685b4482432aa3ca890d9d0dc
http://europepmc.org/articles/PMC4431753?pdf=render

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Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?

Autor: Clemens Fürnsinn, K. Frobel, Anton Luger, Zsuzsanna Lehner, M. Belz, V. A. M. de Cillia, Karin Stadlbauer, B. Brunmair, I. Adorjan, Anna Fenzl, Ingo Rustenbeck, L. Bauer, D. Gruber

Publikováno v: Diabetologia. 55(11)

Inspired by recent speculation about the potential utility of α(2A)-antagonism in the treatment of type 2 diabetes, the study examined the contribution of α(2)-antagonism vs other mechanisms to the antihyperglycaemic activity of the imidazoline (±

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16d5c9ede677d22aeb0effa697ef845
https://pubmed.ncbi.nlm.nih.gov/22898767

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The effects of amino acids on glucose metabolism of isolated rat skeletal muscle are independent of insulin and the mTOR/S6K pathway

Autor: Barbara Brunmair, Zsuzsanna Szöcs, Karin Stadlbauer, Clemens Fürnsinn, Michael Krebs, Anton Luger

Publikováno v: American journal of physiology. Endocrinology and metabolism. 297(3)

Two mechanisms have been proposed for the modulation of skeletal muscle glucose metabolism by amino acids. Whereas studies on humans and cultured cells suggested acute insulin desensitization via mammalian target of rapamycin (mTOR) and its downstrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5316a95f9ccdfb69999c649f4845170
https://pubmed.ncbi.nlm.nih.gov/19622787

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