Zobrazeno 1 - 10
of 640
pro vyhledávání: '"Karin Scharffetter‐Kochanek"'
Autor:
Shiyun Long, Yunchao Zheng, Xiaoling Deng, Jing Guo, Zhe Xu, Karin Scharffetter-Kochanek, Yanmei Dou, Min Jiang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Oocytes play a crucial role in transmitting maternal mitochondrial DNA (mtDNA), essential for the continuation of species. However, the effects of mitochondrial reactive oxygen species (ROS) on mammalian oocyte maturation and mtDNA maintenan
Externí odkaz:
https://doaj.org/article/d0ff61713360493cbaa07d0fe8862f5f
Autor:
Maximilian Wagner, Gaojie Zhu, Fatima Khalid, Tamara Phan, Pallab Maity, Ludmila Lupu, Eric Agyeman-Duah, Sebastian Wiese, Katrin S. Lindenberg, Michael Schön, G. Bernhard Landwehrmeyer, Marianna Penzo, Stefan Kochanek, Karin Scharffetter-Kochanek, Medhanie Mulaw, Sebastian Iben
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106668- (2024)
Cockayne syndrome (CS) is an autosomal recessive disorder of developmental delay, multiple organ system degeneration and signs of premature ageing. We show here, using the RNA-seq data from two CS mutant cell lines, that the CS key transcriptional si
Externí odkaz:
https://doaj.org/article/349b40f258b5492b935e31bfffa22c23
Autor:
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Jünger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schröder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-25 (2022)
Abstract Background While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5+ mese
Externí odkaz:
https://doaj.org/article/4819e8d8b5ba4b6b811f719469da6383
Autor:
Gaojie Zhu, Fatima Khalid, Danhui Zhang, Zhouli Cao, Pallab Maity, Hans A. Kestler, Donata Orioli, Karin Scharffetter-Kochanek, Sebastian Iben
Publikováno v:
Cells, Vol 12, Iss 14, p 1877 (2023)
Mutations in a broad variety of genes can provoke the severe childhood disorder trichothiodystrophy (TTD) that is classified as a DNA repair disease or a transcription syndrome of RNA polymerase II. In an attempt to identify the common underlying pat
Externí odkaz:
https://doaj.org/article/dfec31c8717c48afb3e92c54f7db1d10
Autor:
Astrid M. Schoppa, Xiangxu Chen, Jan-Moritz Ramge, Anna Vikman, Verena Fischer, Melanie Haffner-Luntzer, Jana Riegger, Jan Tuckermann, Karin Scharffetter-Kochanek, Anita Ignatius
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 5 (2022)
Osteoporosis is a systemic metabolic skeletal disease characterized by low bone mass and strength associated with fragility fractures. Oxidative stress, which results from elevated intracellular reactive oxygen species (ROS) and arises in the aging o
Externí odkaz:
https://doaj.org/article/c8aec182ecca4e369874df7f5a60cafd
Autor:
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Ann-Kathrin Dachtler, Korinna Kraft, Markus Stücker, Georg Daeschlein, Michael Jünger, Tobias Görge, Ulrich Meyer-Pannwitt, Cornelia Erfurt-Berge, Charlotte von Engelhardt, Andreas Klare, Christiane Pfeiffer, Jasmina Esterlechner, Hannes M. Schröder, Martin Gasser, Ana M. Waaga-Gasser, Matthias Goebeler, Seda Ballikaya, Samar Sadeghi, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Publikováno v:
JID Innovations, Vol 2, Iss 1, Pp 100067- (2022)
A significant number of chronic venous ulcers (CVUs) fail to heal despite guideline-conform standards of care. Skin-derived ABCB5+ mesenchymal stem cells can dampen the sustained IL-1β‒driven inflammation present in chronic wounds. On the basis of
Externí odkaz:
https://doaj.org/article/30269062a0c04e579251c083a6768869
Autor:
Birte Weber, Ina Lackner, Melanie Haffner-Luntzer, Annette Palmer, Jochen Pressmar, Karin Scharffetter-Kochanek, Bernd Knöll, Hubert Schrezenemeier, Borna Relja, Miriam Kalbitz
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-19 (2019)
Abstract Trauma is the leading cause of mortality in humans below the age of 40. Patients injured by accidents frequently suffer severe multiple trauma, which is life-threatening and leads to death in many cases. In multiply injured patients, thoraci
Externí odkaz:
https://doaj.org/article/38fd9d61a33a4624918ded24a6c5e975
Autor:
Alexandra Aicher, Anca Sindrilaru, Diana Crisan, Wolfgang Thaiss, Jochen Steinacker, Meinrad Beer, Thomas Wiegel, Karin Scharffetter-Kochanek, Ambros J. Beer, Vikas Prasad
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1466 (2022)
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer of the elderly, with high metastatic potential and poor prognosis. In particular, the primary resistance to immune checkpoint inhibitors (ICI) in metastatic (m)MCC patients represents a chal
Externí odkaz:
https://doaj.org/article/7413d052b59f435ead0cf3b994314fda
Autor:
Lea F. Kraus, Katrin Elsharkawi-Welt, Thorsten Peters, Sabine Kastler, Diana Crisan, Anna Lipke, Codruta Tncau, Elisabeth Lormes, Michael Mühlberger, Karin Scharffetter-Kochanek
Publikováno v:
Acta Dermato-Venereologica, Vol 101, Iss 5, p adv00457 (2021)
Externí odkaz:
https://doaj.org/article/d86715ca3aec40939ad4d590fc797ad5
Autor:
Diana Crisan, Ana-Luisa Vargas-Malvar, Sabine Kastler, Gebhard Fröba, Karin Scharffetter-Kochanek, Lars Alexander Schneider
Publikováno v:
Acta Dermato-Venereologica, Vol 101, Iss 4, p adv00440 (2021)
Externí odkaz:
https://doaj.org/article/d5b90d682a9349adb544786c30f77cc2