Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Karin Sauer"'
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTNative dispersion, the terminal stage in biofilm development, is characterized by the active escape of cells from a biofilm, leaving behind central voids or hollow structures. However, much of what is known about the dispersion mechanism stem
Externí odkaz:
https://doaj.org/article/79e1e4243b634f67be8d519270e5b9ba
Autor:
Matthew F. Kaleta, Olga E. Petrova, Claudia Zampaloni, Fernando Garcia-Alcalde, Matthew Parker, Karin Sauer
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Transcriptomic studies have revealed a large number of uncharacterized genes that are differentially expressed in biofilms, which may be important in regulating biofilm phenotypes such as resistance to antimicrobial agents. To identify biofi
Externí odkaz:
https://doaj.org/article/e446955beeea4e8faa141ae2c3ef3b3d
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT Dispersion is an active process exhibited by Pseudomonas aeruginosa during the late stages of biofilm development or in response to various cues, including nitric oxide and glutamate. Upon cue sensing, biofilm cells employ enzymes that activ
Externí odkaz:
https://doaj.org/article/cb8ac9d44bc342a8831827e8da6b1955
Autor:
Soyoung Park, Karin Sauer
Publikováno v:
Biofilm, Vol 3, Iss , Pp 100059- (2021)
The Pseudomonas aeruginosa orphan sensor SagS (PA2824) was initially reported as one of three orphan sensor kinases capable of activating HptB, a component of the HptB signaling pathway that intersects with the Gac/Rsm signaling pathway and fine-tune
Externí odkaz:
https://doaj.org/article/4d54866836ef419f8483f274ae9e9e59
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010144 (2021)
Persistent bacterial infections do not respond to current antibiotic treatments and thus present a great medical challenge. These conditions have been linked to the formation of dormant subpopulations of bacteria, known as persister cells, that are g
Externí odkaz:
https://doaj.org/article/76cca8d3bf7b4527929e3133845eeb24
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Pathogens sense and respond to signals and cues present in their environment, including host-derived small molecules to modulate the expression of their virulence repertoire. Here, we demonstrate that the opportunistic pathogen Pseudomonas aeruginosa
Externí odkaz:
https://doaj.org/article/315ff49d69be4936b3a40f562a43187c
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT The hybrid sensor kinase SagS of Pseudomonas aeruginosa plays a key role in the transition from the planktonic to the biofilm mode of growth. Recently, we have shown that distinct sets of residues in its periplasmic HmsP sensory domain are i
Externí odkaz:
https://doaj.org/article/9104c3a7d2ca43e5b2ed8eeac4bca185
Publikováno v:
mSphere, Vol 3, Iss 3 (2018)
ABSTRACT The formation of inherently drug-tolerant biofilms by the opportunistic pathogen Pseudomonas aeruginosa requires the sensor-regulator hybrid SagS, with ΔsagS biofilms being unstructured and exhibiting increased antimicrobial susceptibility.
Externí odkaz:
https://doaj.org/article/5ffcc29b2fc64c32babb6f18b14b5425
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Recently, we reported that the stiffness of poly(dimethylsiloxane) (PDMS) affects the attachment of Pseudomonas aeruginosa, and the morphology and antibiotic susceptibility of attached cells. To further understand how P. aeruginosa responses to mater
Externí odkaz:
https://doaj.org/article/e69406ebb97944819ce6f3f333bd4ace
Publikováno v:
Pharmaceuticals, Vol 8, Iss 4, Pp 816-835 (2015)
Biofilms are complex communities of microorganisms in organized structures attached to surfaces. Importantly, biofilms are a major cause of bacterial infections in humans, and remain one of the most significant challenges to modern medical practice.
Externí odkaz:
https://doaj.org/article/1369b565d7f0415a81d7cb568ce23705